MicroRNA-30d deficiency during preconception affects endometrial receptivity by decreasing implantation rates and impairing fetal growth

Maternal–embryonic crosstalk between the endometrium and the preimplantation embryo is required for normal pregnancy. Our previous results demonstrated that maternal microRNAs secreted into the endometrial fluid, specifically miR-30d, act as a transcriptomic regulator of the preimplantation embryo b...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2019-07, Vol.221 (1), p.46.e1-46.e16
Hauptverfasser:	Balaguer, Nuria, Moreno, Inmaculada, Herrero, María, Gonzáléz-Monfort, Marta, Vilella, Felipe, Simón, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Embryo Implantation - genetics Embryo Transfer Endometrium - metabolism epigenetic Female Fetal Development - genetics fetal growth restriction Gene Expression Regulation, Developmental Homeodomain Proteins - genetics Homeodomain Proteins - metabolism implantation Leukemia Inhibitory Factor - genetics Leukemia Inhibitory Factor - metabolism maternal–embryonic crosstalk Mice Mice, Knockout microRNA MicroRNAs - genetics miR-30d MSX1 Transcription Factor - genetics MSX1 Transcription Factor - metabolism Placenta Placentation Pregnancy Real-Time Polymerase Chain Reaction Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Receptors, Progesterone - genetics Receptors, Progesterone - metabolism small for gestational age
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