Myocardial infarction with non-obstructive coronary arteries (MINOCA) in Chinese patients: Clinical features, treatment and 1 year follow-up
Myocardial infarction with non-obstructive coronary arteries (MINOCA) is characterised by clinical evidence of myocardial infarction with normal or near-normal coronary arteries on angiography (stenosis
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| Veröffentlicht in: | International journal of cardiology 2019-07, Vol.287, p.27-31 |
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| container_title | International journal of cardiology |
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| creator | Abdu, Fuad A. Liu, Lu Mohammed, Abdul-Quddus Luo, Yanru Xu, Siling Auckle, Ranshaka Xu, Yawei Che, Wenliang |
| description | Myocardial infarction with non-obstructive coronary arteries (MINOCA) is characterised by clinical evidence of myocardial infarction with normal or near-normal coronary arteries on angiography (stenosis |
| doi_str_mv | 10.1016/j.ijcard.2019.02.036 |
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The data of 2029 patients with acute myocardial infarction were consecutively collected. MINOCA patients were identified with coronary angiography (<50% stenosis). Clinical features, medication management and cardiovascular events were assessed.
One hundred and twenty-eight patients (6.3%) were diagnosed as MINOCA. Compared with the myocardial infarction with obstructive coronary arteries (MI-CAD) patients, the prevalence of traditional risk factors of CAD was lower in MINOCA patients. The levels of TG, LDL-C, cTnT, CK-MB and myoglobin in the MINOCA group were significantly lower, whereas LVEF was higher. MINOCA patients are less likely to receive secondary prevention medication for MI, and use of all recommended drugs decreased at one-year follow-up. MACE in the MINOCA group was lower. After adjusting related risk factors, logistic analysis showed MINOCA was independently associated with lower risk of MACE. Independent predictors for MACE in MINOCA patients were older age (≥60 years), females, atrial fibrillation and reduced LVEF.
Compared with MI-CAD, MINOCA was accompanied by fewer traditional risk factors of CAD, less likely to be discharged upon secondary prevention medication of MI and the occurrence of MACE during 1 year follow-up was lower. Older age (≥60 years), females, atrial fibrillation and reduced LVEF were independent risk factors for MACE in MINOCA patients within one year.
•This study is the first to investigate clinical features among Chinese MINOCA patients and one-year follow-up on medication management and cardiovascular events.•Compared with MI-CAD, MINOCA had a younger age of onset, was more common in females, and was accompanied by fewer traditional risk factors of CAD.•Compared with MI-CAD, MINOCA patients are less likely to receive secondary prevention medication for MI, and use of all recommended drugs decreased at one-year follow-up.•Compared with MI-CAD, MACE during the 1-year follow-up was lower in MINOCA patients.•The independent risk factors for MACE were older age (≥60 years old), females, atrial fibrillation and reduced LVEF.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2019.02.036</identifier><identifier>PMID: 30826195</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>1 year follow-up ; Aged ; China - epidemiology ; Clinical features ; Coronary Angiography - methods ; Coronary Artery Disease - complications ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - therapy ; Coronary Circulation - physiology ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - physiopathology ; Electrocardiography ; Female ; Fibrinolytic Agents - therapeutic use ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; MINOCA ; Myocardial Infarction - complications ; Myocardial Infarction - epidemiology ; Myocardial Infarction - therapy ; Prevalence ; Prospective Studies ; Registries ; Risk Factors ; Thrombolytic Therapy - methods ; Tomography, Optical Coherence ; Treatment ; Ultrasonography, Interventional</subject><ispartof>International journal of cardiology, 2019-07, Vol.287, p.27-31</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-f02b9c38de818aa220ad9560c1afaa663c201563396c370a07c8511427bd16053</citedby><cites>FETCH-LOGICAL-c362t-f02b9c38de818aa220ad9560c1afaa663c201563396c370a07c8511427bd16053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167527318347673$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30826195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdu, Fuad A.</creatorcontrib><creatorcontrib>Liu, Lu</creatorcontrib><creatorcontrib>Mohammed, Abdul-Quddus</creatorcontrib><creatorcontrib>Luo, Yanru</creatorcontrib><creatorcontrib>Xu, Siling</creatorcontrib><creatorcontrib>Auckle, Ranshaka</creatorcontrib><creatorcontrib>Xu, Yawei</creatorcontrib><creatorcontrib>Che, Wenliang</creatorcontrib><title>Myocardial infarction with non-obstructive coronary arteries (MINOCA) in Chinese patients: Clinical features, treatment and 1 year follow-up</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Myocardial infarction with non-obstructive coronary arteries (MINOCA) is characterised by clinical evidence of myocardial infarction with normal or near-normal coronary arteries on angiography (stenosis<50%). We investigated clinical features among Chinese MINOCA patients and one-year follow-up on medication management and cardiovascular events.
The data of 2029 patients with acute myocardial infarction were consecutively collected. MINOCA patients were identified with coronary angiography (<50% stenosis). Clinical features, medication management and cardiovascular events were assessed.
One hundred and twenty-eight patients (6.3%) were diagnosed as MINOCA. Compared with the myocardial infarction with obstructive coronary arteries (MI-CAD) patients, the prevalence of traditional risk factors of CAD was lower in MINOCA patients. The levels of TG, LDL-C, cTnT, CK-MB and myoglobin in the MINOCA group were significantly lower, whereas LVEF was higher. MINOCA patients are less likely to receive secondary prevention medication for MI, and use of all recommended drugs decreased at one-year follow-up. MACE in the MINOCA group was lower. After adjusting related risk factors, logistic analysis showed MINOCA was independently associated with lower risk of MACE. Independent predictors for MACE in MINOCA patients were older age (≥60 years), females, atrial fibrillation and reduced LVEF.
Compared with MI-CAD, MINOCA was accompanied by fewer traditional risk factors of CAD, less likely to be discharged upon secondary prevention medication of MI and the occurrence of MACE during 1 year follow-up was lower. Older age (≥60 years), females, atrial fibrillation and reduced LVEF were independent risk factors for MACE in MINOCA patients within one year.
•This study is the first to investigate clinical features among Chinese MINOCA patients and one-year follow-up on medication management and cardiovascular events.•Compared with MI-CAD, MINOCA had a younger age of onset, was more common in females, and was accompanied by fewer traditional risk factors of CAD.•Compared with MI-CAD, MINOCA patients are less likely to receive secondary prevention medication for MI, and use of all recommended drugs decreased at one-year follow-up.•Compared with MI-CAD, MACE during the 1-year follow-up was lower in MINOCA patients.•The independent risk factors for MACE were older age (≥60 years old), females, atrial fibrillation and reduced LVEF.</description><subject>1 year follow-up</subject><subject>Aged</subject><subject>China - epidemiology</subject><subject>Clinical features</subject><subject>Coronary Angiography - methods</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - therapy</subject><subject>Coronary Circulation - physiology</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - physiopathology</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Fibrinolytic Agents - therapeutic use</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MINOCA</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Infarction - therapy</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Thrombolytic Therapy - methods</subject><subject>Tomography, Optical Coherence</subject><subject>Treatment</subject><subject>Ultrasonography, Interventional</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUha2qqB3avkGFvCwSCf5JnKQLpCqCUqk_G1hbd5wb1aOMPdhOq9nxBH0V3oknwaMpLFnZss85V_c7hJxzVnLG1cdVaVcGwlAKxruSiZJJdUAWvG2qgjd1dUgWWdYUtWjkMXkb44oxVnVde0SOJWuF4l29IC93W79LsTBR60YIJlnv6LNNj9R5V_hlTGHOj09IjQ_eQdhSCAmDxUgv7m7uH_qr99lK-0frMCLdQLLoUryk_WSdNTl4REhzwPiBppCv6_xNwQ2U__75a4sQ6OinyT8X8-aUvBlhinj2ep6Q718-f-u_FrcP1zf91W1hpBKpGJlYdka2A7a8BRCCwdDVihkOI4BS0mQotZKyU0Y2DFhj2przSjTLgStWyxNysc_dBP9jxpj02kaD0wQO_Ry1yBi7WlZtk6XVXmqCjzHgqDfBrjMGzZneNaFXet-E3jWhmdC5iWx79zphXq5x-Gf6iz4LPu0FmPd8shh0NBmcwcEGNEkP3v5_wh8tEJ3Y</recordid><startdate>20190715</startdate><enddate>20190715</enddate><creator>Abdu, Fuad A.</creator><creator>Liu, Lu</creator><creator>Mohammed, Abdul-Quddus</creator><creator>Luo, Yanru</creator><creator>Xu, Siling</creator><creator>Auckle, Ranshaka</creator><creator>Xu, Yawei</creator><creator>Che, Wenliang</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190715</creationdate><title>Myocardial infarction with non-obstructive coronary arteries (MINOCA) in Chinese patients: Clinical features, treatment and 1 year follow-up</title><author>Abdu, Fuad A. ; Liu, Lu ; Mohammed, Abdul-Quddus ; Luo, Yanru ; Xu, Siling ; Auckle, Ranshaka ; Xu, Yawei ; Che, Wenliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-f02b9c38de818aa220ad9560c1afaa663c201563396c370a07c8511427bd16053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>1 year follow-up</topic><topic>Aged</topic><topic>China - epidemiology</topic><topic>Clinical features</topic><topic>Coronary Angiography - methods</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - therapy</topic><topic>Coronary Circulation - physiology</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Coronary Vessels - physiopathology</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Fibrinolytic Agents - therapeutic use</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MINOCA</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Myocardial Infarction - therapy</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Thrombolytic Therapy - methods</topic><topic>Tomography, Optical Coherence</topic><topic>Treatment</topic><topic>Ultrasonography, Interventional</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdu, Fuad A.</creatorcontrib><creatorcontrib>Liu, Lu</creatorcontrib><creatorcontrib>Mohammed, Abdul-Quddus</creatorcontrib><creatorcontrib>Luo, Yanru</creatorcontrib><creatorcontrib>Xu, Siling</creatorcontrib><creatorcontrib>Auckle, Ranshaka</creatorcontrib><creatorcontrib>Xu, Yawei</creatorcontrib><creatorcontrib>Che, Wenliang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdu, Fuad A.</au><au>Liu, Lu</au><au>Mohammed, Abdul-Quddus</au><au>Luo, Yanru</au><au>Xu, Siling</au><au>Auckle, Ranshaka</au><au>Xu, Yawei</au><au>Che, Wenliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial infarction with non-obstructive coronary arteries (MINOCA) in Chinese patients: Clinical features, treatment and 1 year follow-up</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2019-07-15</date><risdate>2019</risdate><volume>287</volume><spage>27</spage><epage>31</epage><pages>27-31</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><abstract>Myocardial infarction with non-obstructive coronary arteries (MINOCA) is characterised by clinical evidence of myocardial infarction with normal or near-normal coronary arteries on angiography (stenosis<50%). We investigated clinical features among Chinese MINOCA patients and one-year follow-up on medication management and cardiovascular events.
The data of 2029 patients with acute myocardial infarction were consecutively collected. MINOCA patients were identified with coronary angiography (<50% stenosis). Clinical features, medication management and cardiovascular events were assessed.
One hundred and twenty-eight patients (6.3%) were diagnosed as MINOCA. Compared with the myocardial infarction with obstructive coronary arteries (MI-CAD) patients, the prevalence of traditional risk factors of CAD was lower in MINOCA patients. The levels of TG, LDL-C, cTnT, CK-MB and myoglobin in the MINOCA group were significantly lower, whereas LVEF was higher. MINOCA patients are less likely to receive secondary prevention medication for MI, and use of all recommended drugs decreased at one-year follow-up. MACE in the MINOCA group was lower. After adjusting related risk factors, logistic analysis showed MINOCA was independently associated with lower risk of MACE. Independent predictors for MACE in MINOCA patients were older age (≥60 years), females, atrial fibrillation and reduced LVEF.
Compared with MI-CAD, MINOCA was accompanied by fewer traditional risk factors of CAD, less likely to be discharged upon secondary prevention medication of MI and the occurrence of MACE during 1 year follow-up was lower. Older age (≥60 years), females, atrial fibrillation and reduced LVEF were independent risk factors for MACE in MINOCA patients within one year.
•This study is the first to investigate clinical features among Chinese MINOCA patients and one-year follow-up on medication management and cardiovascular events.•Compared with MI-CAD, MINOCA had a younger age of onset, was more common in females, and was accompanied by fewer traditional risk factors of CAD.•Compared with MI-CAD, MINOCA patients are less likely to receive secondary prevention medication for MI, and use of all recommended drugs decreased at one-year follow-up.•Compared with MI-CAD, MACE during the 1-year follow-up was lower in MINOCA patients.•The independent risk factors for MACE were older age (≥60 years old), females, atrial fibrillation and reduced LVEF.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30826195</pmid><doi>10.1016/j.ijcard.2019.02.036</doi><tpages>5</tpages></addata></record> |
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| ispartof | International journal of cardiology, 2019-07, Vol.287, p.27-31 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 1 year follow-up Aged China - epidemiology Clinical features Coronary Angiography - methods Coronary Artery Disease - complications Coronary Artery Disease - epidemiology Coronary Artery Disease - therapy Coronary Circulation - physiology Coronary Vessels - diagnostic imaging Coronary Vessels - physiopathology Electrocardiography Female Fibrinolytic Agents - therapeutic use Follow-Up Studies Humans Male Middle Aged MINOCA Myocardial Infarction - complications Myocardial Infarction - epidemiology Myocardial Infarction - therapy Prevalence Prospective Studies Registries Risk Factors Thrombolytic Therapy - methods Tomography, Optical Coherence Treatment Ultrasonography, Interventional |
| title | Myocardial infarction with non-obstructive coronary arteries (MINOCA) in Chinese patients: Clinical features, treatment and 1 year follow-up |
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