Activation of anti-oxidant of curcumin pyrazole derivatives through preservation of mitochondria function and Nrf2 signaling pathway

Oxidative stress is an important cause of neurodegenerative diseases. Antioxidant is an potential important method to treat such diseases. The aim of this study is to discover new and effective antioxidants and their mechanism. The neuroprotective effect of six curcumin pyrozole compounds were first...

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Veröffentlicht in:	Neurochemistry international 2019-05, Vol.125, p.82-90
Hauptverfasser:	Liao, Liping, Shi, Jinguo, Jiang, Caibao, Zhang, Liantao, Feng, Lisi, Liu, Jiayong, Zhang, Jingxia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - chemistry Antioxidants - pharmacology Cell Survival - drug effects Cell Survival - physiology Curcumin Curcumin - chemistry Curcumin - pharmacology Dose-Response Relationship, Drug Mitochondria Mitochondria - drug effects Mitochondria - physiology NF-E2-Related Factor 2 - metabolism Nitroprusside - toxicity Nrf2 Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology PC12 Cells Pyrazoles - pharmacology Rats Signal Transduction - drug effects Signal Transduction - physiology
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