Ascl1 Regulates Electric Field-Induced Neuronal Differentiation Through PI3K/Akt Pathway

Directing differentiation of neural stem/progenitor cells (NSCs/NPCs) to produce functional neurons is one of the greatest challenges in regenerative medicine. Our previous paper has confirmed that electrical stimulation has a high efficiency of triggering neuronal differentiation by using isolated...

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Veröffentlicht in:	Neuroscience 2019-04, Vol.404, p.141-152
Hauptverfasser:	Dong, Zhi-yong, Pei, Zhe, Wang, Yan-ling, Li, Zhe, Khan, Amber, Meng, Xiao-ting
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascl1 Basic Helix-Loop-Helix Transcription Factors - biosynthesis Cell Differentiation - physiology Cells, Cultured electric fields Electric Stimulation - methods Mice Mice, Inbred C57BL neural progenitor cells Neural Stem Cells - metabolism neuronal differentiation Phosphatidylinositol 3-Kinases - metabolism PI3K/Akt Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - physiology
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