A Species-Correlated Transitional Residue D132 on Human FMRP Plays a Role in Nuclear Localization via an RNA-Dependent Interaction With PABP1

Fragile X mental retardation protein (FMRP), a key determinant of normal brain development and neuronal plasticity, plays critical roles in nucleocytoplasmic shuttling of mRNAs. However, the factors involved in FMRP nuclear localization remain to be determined. Using cross-species sequence compariso...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2019-04, Vol.404, p.282-296
Hauptverfasser:	Zhou, Yong-Ting, Long, Jing-Yi, Fu, Jun-Yi, Sun, Wei-Wen, Hu, Fei, Huang, Hao-Ying, Li, Wei, Gao, Mei-Mei, Shu, Yousheng, Yi, Yong-Hong, Long, Yue-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Line, Tumor Cell Nucleus - metabolism evolution FMRP Fragile X Mental Retardation Protein - chemistry Fragile X Mental Retardation Protein - genetics Fragile X Mental Retardation Protein - metabolism HEK293 Cells Humans Mice nuclear localization poly(A)-binding protein 1 Poly(A)-Binding Protein I - chemistry Poly(A)-Binding Protein I - genetics Poly(A)-Binding Protein I - metabolism Protein Binding - physiology Protein Structure, Secondary protein-protein interaction RNA - chemistry RNA - genetics RNA - metabolism Species Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!