Revealing cellular and molecular transitions in neonatal germ cell differentiation using single cell RNA sequencing

Neonatal germ cell development provides the foundation of spermatogenesis. However, a systematic understanding of this process is still limited. To resolve cellular and molecular heterogeneity in this process, we profiled single cell transcriptomes of undifferentiated germ cells from neonatal mouse...

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Veröffentlicht in:	Development (Cambridge) 2019-03, Vol.146 (6)
Hauptverfasser:	Liao, Jinyue, Ng, Shuk Han, Luk, Alfred Chun, Suen, Hoi Ching, Qian, Yan, Lee, Annie Wing Tung, Tu, Jiajie, Fung, Jacqueline Chak Lam, Tang, Nelson Leung Sang, Feng, Bo, Chan, Wai Yee, Fouchet, Pierre, Hobbs, Robin M, Lee, Tin Lap
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis Cell Adhesion Cell Differentiation Gene Expression Profiling Gene Expression Regulation, Developmental Male MAP Kinase Signaling System Mice Microscopy, Fluorescence Octamer Transcription Factor-3 - physiology Receptors, Retinoic Acid - physiology Receptors, Urokinase Plasminogen Activator - physiology Retinoic Acid Receptor gamma Sequence Analysis, RNA Spermatogenesis - genetics Spermatogonia - cytology Transcriptome Tretinoin - physiology
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