Synthesis and antitumor activity of novel steroidal imidazolium salt derivatives

Sixty-one novel steroidal imidazolium salt derivatives were synthesized and evaluated in vitro against a panel of human tumor cell lines. The results showed that diosgenin‒imidazolium salt derivatives displayed much higher cytotoxic activities than cholesterol‒imidazolium salts and dehydroepiandrost...

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Veröffentlicht in:	European journal of medicinal chemistry 2019-04, Vol.168, p.232-252
Hauptverfasser:	Deng, Guogang, Zhou, Bei, Wang, Jing, Chen, Zhuo, Gong, Liang, Gong, Yaxiao, Wu, Dongmei, Li, Yan, Zhang, Hongbin, Yang, Xiaodong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor activities Cholesterol Dehydroepiandrosterone Diosgenin Imidazolium salt Structure–activity relationships
Online-Zugang:	Volltext
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