The potential of breath analysis to improve outcome for patients with lung cancer
Lung cancer remains the most common cause of cancer related death in both the UK and USA. Development of diagnostic approaches that have the ability to detect lung cancer early are a research priority with potential to improve survival. Analysis of exhaled breath metabolites, or volatile organic com...
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| Veröffentlicht in: | Journal of breath research 2019-04, Vol.13 (3), p.034002-034002 |
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| container_issue | 3 |
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| container_title | Journal of breath research |
| container_volume | 13 |
| creator | Antoniou, S X Gaude, E Ruparel, M van der Schee, M P Janes, S M Rintoul, R C |
| description | Lung cancer remains the most common cause of cancer related death in both the UK and USA. Development of diagnostic approaches that have the ability to detect lung cancer early are a research priority with potential to improve survival. Analysis of exhaled breath metabolites, or volatile organic compounds (VOCs) is an area of considerable interest as it could fulfil such requirements. Numerous studies have shown that VOC profiles are different in the breath of patients with lung cancer compared to healthy individuals or those with non-malignant lung diseases. This review provides a scientific and clinical assessment of the potential value of a breath test in lung cancer. It discusses the current understanding of metabolic pathways that contribute to exhaled VOC production in lung cancer and reviews the research conducted to date. Finally, we highlight important areas for future research and discuss how a breath test could be incorporated into various clinical pathways. |
| doi_str_mv | 10.1088/1752-7163/ab0bee |
| format | Article |
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Finally, we highlight important areas for future research and discuss how a breath test could be incorporated into various clinical pathways.</description><subject>breath analysis</subject><subject>Breath tests</subject><subject>Breath Tests - methods</subject><subject>cancer metabolism</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Treatment Outcome</subject><subject>VOCs</subject><subject>Volatile organic compounds</subject><issn>1752-7163</issn><issn>1752-7155</issn><issn>1752-7163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9LwzAUx4Mobk7vniTgQQ_OJU3bpEcZ_oKBCPMckjZxGW1Tk1bZf29K5xQRTy8vfL7f994XgFOMrjFibIZpEk0pTslMSCSV2gPj3df-j_cIHHm_RiiNEcsOwYggFkWU4jF4Xq4UbGyr6taIEloNpVOiXUFRi3LjjYethaZqnH1X0HZtbisFtXWwEa0JIg8_TKDLrn6Fuahz5Y7BgRalVyfbOgEvd7fL-cN08XT_OL9ZTPOYsHYqMylTnLCCUSywwjkqaIGSjOAs1TqTCCdFLGghw86aZDpOolRlMvQyZkzmZAIuB9-w21unfMsr43NVlqJWtvM8wiycT5IkDej5L3RtOxcODBQlBKVZEvcUGqjcWe-d0rxxphJuwzHifdy8z5P3efIh7iA52xp3slLFTvCVbwCuBsDY5nvoP34Xf-Br6TgmnHBEYoQi3hSafAK0kpan</recordid><startdate>20190424</startdate><enddate>20190424</enddate><creator>Antoniou, S X</creator><creator>Gaude, E</creator><creator>Ruparel, M</creator><creator>van der Schee, M P</creator><creator>Janes, S M</creator><creator>Rintoul, R C</creator><general>IOP Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3271-764X</orcidid><orcidid>https://orcid.org/0000-0001-8523-7792</orcidid></search><sort><creationdate>20190424</creationdate><title>The potential of breath analysis to improve outcome for patients with lung cancer</title><author>Antoniou, S X ; Gaude, E ; Ruparel, M ; van der Schee, M P ; Janes, S M ; Rintoul, R C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-b9bb6158d871a1e1c0d7d0593196ff9b015d4a7db640f39f4526e9bdb6b488bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>breath analysis</topic><topic>Breath tests</topic><topic>Breath Tests - methods</topic><topic>cancer metabolism</topic><topic>Humans</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Treatment Outcome</topic><topic>VOCs</topic><topic>Volatile organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Antoniou, S X</creatorcontrib><creatorcontrib>Gaude, E</creatorcontrib><creatorcontrib>Ruparel, M</creatorcontrib><creatorcontrib>van der Schee, M P</creatorcontrib><creatorcontrib>Janes, S M</creatorcontrib><creatorcontrib>Rintoul, R C</creatorcontrib><creatorcontrib>The LuCID Group</creatorcontrib><creatorcontrib>on behalf of LuCID research group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of breath research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Antoniou, S X</au><au>Gaude, E</au><au>Ruparel, M</au><au>van der Schee, M P</au><au>Janes, S M</au><au>Rintoul, R C</au><aucorp>The LuCID Group</aucorp><aucorp>on behalf of LuCID research group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The potential of breath analysis to improve outcome for patients with lung cancer</atitle><jtitle>Journal of breath research</jtitle><stitle>JBR</stitle><addtitle>J. Breath Res</addtitle><date>2019-04-24</date><risdate>2019</risdate><volume>13</volume><issue>3</issue><spage>034002</spage><epage>034002</epage><pages>034002-034002</pages><issn>1752-7163</issn><issn>1752-7155</issn><eissn>1752-7163</eissn><coden>JBROBW</coden><abstract>Lung cancer remains the most common cause of cancer related death in both the UK and USA. Development of diagnostic approaches that have the ability to detect lung cancer early are a research priority with potential to improve survival. Analysis of exhaled breath metabolites, or volatile organic compounds (VOCs) is an area of considerable interest as it could fulfil such requirements. Numerous studies have shown that VOC profiles are different in the breath of patients with lung cancer compared to healthy individuals or those with non-malignant lung diseases. This review provides a scientific and clinical assessment of the potential value of a breath test in lung cancer. 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| fulltext | fulltext |
| identifier | ISSN: 1752-7163 |
| ispartof | Journal of breath research, 2019-04, Vol.13 (3), p.034002-034002 |
| issn | 1752-7163 1752-7155 1752-7163 |
| language | eng |
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| source | MEDLINE; Institute of Physics Journals |
| subjects | breath analysis Breath tests Breath Tests - methods cancer metabolism Humans Lung cancer Lung Neoplasms - diagnosis Treatment Outcome VOCs Volatile organic compounds |
| title | The potential of breath analysis to improve outcome for patients with lung cancer |
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