A cohort study of maternal screening for congenital Toxoplasma gondii infection: 12 years' experience
Primary infection with Toxoplasma gondii (T. gondii) during pregnancy may cause congenital infection of the infant. This study evaluated whether screening using IgG avidity and multiplex-nested polymerase chain reaction (PCR) methods was effective for detecting a high-risk pregnancy for congenital T...
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| Veröffentlicht in: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2019-06, Vol.25 (6), p.427-430 |
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| container_title | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy |
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| creator | Yamada, Hideto Tanimura, Kenji Deguchi, Masashi Tairaku, Shinya Morizane, Mayumi Uchida, Akiko Ebina, Yasuhiko Nishikawa, Akira |
| description | Primary infection with Toxoplasma gondii (T. gondii) during pregnancy may cause congenital infection of the infant. This study evaluated whether screening using IgG avidity and multiplex-nested polymerase chain reaction (PCR) methods was effective for detecting a high-risk pregnancy for congenital T. gondii infection. In a prospective cohort study serum T. gondii IgG avidity was measured in 469 pregnant women who had a positive test for T. gondii antibody plus a positive or equivocal test for IgM. Multiplex-nested PCR for T. gondii DNA on amniotic fluid, maternal blood, and neonatal blood was performed with informed consent. Low (35%) IgG avidity indices were found in 104 (22.2%), 30 (6.4%), and 305 (71.4%), respectively. A total of 12 cases had a positive PCR test for amniotic fluids of the prenatal amniocentesis or at birth, or neonatal blood. Seven of the 12 cases were diagnosed as having congenital T. gondii infection, and they had low IgG avidity indices. Congenital T. gondii infection screening using of IgG avidity and multiplex-nested PCR methods for pregnant women with a positive test for T. gondii antibody plus a positive or equivocal test for T. gondii IgM was useful for detecting a high-risk pregnancy and diagnosing congenital T. gondii infection. |
| doi_str_mv | 10.1016/j.jiac.2019.01.009 |
| format | Article |
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This study evaluated whether screening using IgG avidity and multiplex-nested polymerase chain reaction (PCR) methods was effective for detecting a high-risk pregnancy for congenital T. gondii infection. In a prospective cohort study serum T. gondii IgG avidity was measured in 469 pregnant women who had a positive test for T. gondii antibody plus a positive or equivocal test for IgM. Multiplex-nested PCR for T. gondii DNA on amniotic fluid, maternal blood, and neonatal blood was performed with informed consent. Low (<30%), borderline (30–35%), and high (>35%) IgG avidity indices were found in 104 (22.2%), 30 (6.4%), and 305 (71.4%), respectively. A total of 12 cases had a positive PCR test for amniotic fluids of the prenatal amniocentesis or at birth, or neonatal blood. Seven of the 12 cases were diagnosed as having congenital T. gondii infection, and they had low IgG avidity indices. Congenital T. gondii infection screening using of IgG avidity and multiplex-nested PCR methods for pregnant women with a positive test for T. gondii antibody plus a positive or equivocal test for T. gondii IgM was useful for detecting a high-risk pregnancy and diagnosing congenital T. gondii infection.</description><identifier>ISSN: 1341-321X</identifier><identifier>EISSN: 1437-7780</identifier><identifier>DOI: 10.1016/j.jiac.2019.01.009</identifier><identifier>PMID: 30824301</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Congenital toxoplasmosis ; IgG avidity ; Polymerase chain reaction ; Prenatal diagnosis ; Toxoplasma</subject><ispartof>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2019-06, Vol.25 (6), p.427-430</ispartof><rights>2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases</rights><rights>Copyright © 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. 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This study evaluated whether screening using IgG avidity and multiplex-nested polymerase chain reaction (PCR) methods was effective for detecting a high-risk pregnancy for congenital T. gondii infection. In a prospective cohort study serum T. gondii IgG avidity was measured in 469 pregnant women who had a positive test for T. gondii antibody plus a positive or equivocal test for IgM. Multiplex-nested PCR for T. gondii DNA on amniotic fluid, maternal blood, and neonatal blood was performed with informed consent. Low (<30%), borderline (30–35%), and high (>35%) IgG avidity indices were found in 104 (22.2%), 30 (6.4%), and 305 (71.4%), respectively. A total of 12 cases had a positive PCR test for amniotic fluids of the prenatal amniocentesis or at birth, or neonatal blood. Seven of the 12 cases were diagnosed as having congenital T. gondii infection, and they had low IgG avidity indices. Congenital T. gondii infection screening using of IgG avidity and multiplex-nested PCR methods for pregnant women with a positive test for T. gondii antibody plus a positive or equivocal test for T. gondii IgM was useful for detecting a high-risk pregnancy and diagnosing congenital T. gondii infection.</description><subject>Congenital toxoplasmosis</subject><subject>IgG avidity</subject><subject>Polymerase chain reaction</subject><subject>Prenatal diagnosis</subject><subject>Toxoplasma</subject><issn>1341-321X</issn><issn>1437-7780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PHSEUhklTU63tH-iiYdduZuQwHzDGjTFtNTFxo0l3hIHDLTczcIW5jfffy-3VLl0B5zzvm_AQ8gVYDQz6s3W99trUnMFQM6gZG96RE2gbUQkh2ftyb1qoGg6_j8nHnNeMgeik_ECOGyZ52zA4IXhJTfwT00LzsrU7Gh2d9YIp6IlmkxCDDyvqYipYWJXXUhb38SluJp1nTVcxWO-pDw7N4mM4p8DpDnXK3yg-bTB5DAY_kSOnp4yfX85T8vDzx_3VdXV79-vm6vK2Ml3TLpVmneDG8nFAOXat7C2O2uheigaFsIxzJ9rROiuhk7zMtTOgheSDGGzvWHNKvh96Nyk-bjEvavbZ4DTpgHGbFQcpOpB9t0f5ATUp5pzQqU3ys047BUzt9aq12utVe72KgSp6S-jrS_92nNH-j7z6LMDFAcDyy78ek8rmnwHrUxGkbPRv9T8DqOiMhg</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Yamada, Hideto</creator><creator>Tanimura, Kenji</creator><creator>Deguchi, Masashi</creator><creator>Tairaku, Shinya</creator><creator>Morizane, Mayumi</creator><creator>Uchida, Akiko</creator><creator>Ebina, Yasuhiko</creator><creator>Nishikawa, Akira</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9839-2214</orcidid></search><sort><creationdate>20190601</creationdate><title>A cohort study of maternal screening for congenital Toxoplasma gondii infection: 12 years' experience</title><author>Yamada, Hideto ; Tanimura, Kenji ; Deguchi, Masashi ; Tairaku, Shinya ; Morizane, Mayumi ; Uchida, Akiko ; Ebina, Yasuhiko ; Nishikawa, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-a0572cd2b9e8b5486debaca6873e77d022f74bdfd81582a68afc1a782979d6f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Congenital toxoplasmosis</topic><topic>IgG avidity</topic><topic>Polymerase chain reaction</topic><topic>Prenatal diagnosis</topic><topic>Toxoplasma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, Hideto</creatorcontrib><creatorcontrib>Tanimura, Kenji</creatorcontrib><creatorcontrib>Deguchi, Masashi</creatorcontrib><creatorcontrib>Tairaku, Shinya</creatorcontrib><creatorcontrib>Morizane, Mayumi</creatorcontrib><creatorcontrib>Uchida, Akiko</creatorcontrib><creatorcontrib>Ebina, Yasuhiko</creatorcontrib><creatorcontrib>Nishikawa, Akira</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, Hideto</au><au>Tanimura, Kenji</au><au>Deguchi, Masashi</au><au>Tairaku, Shinya</au><au>Morizane, Mayumi</au><au>Uchida, Akiko</au><au>Ebina, Yasuhiko</au><au>Nishikawa, Akira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A cohort study of maternal screening for congenital Toxoplasma gondii infection: 12 years' experience</atitle><jtitle>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</jtitle><addtitle>J Infect Chemother</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>25</volume><issue>6</issue><spage>427</spage><epage>430</epage><pages>427-430</pages><issn>1341-321X</issn><eissn>1437-7780</eissn><abstract>Primary infection with Toxoplasma gondii (T. gondii) during pregnancy may cause congenital infection of the infant. This study evaluated whether screening using IgG avidity and multiplex-nested polymerase chain reaction (PCR) methods was effective for detecting a high-risk pregnancy for congenital T. gondii infection. In a prospective cohort study serum T. gondii IgG avidity was measured in 469 pregnant women who had a positive test for T. gondii antibody plus a positive or equivocal test for IgM. Multiplex-nested PCR for T. gondii DNA on amniotic fluid, maternal blood, and neonatal blood was performed with informed consent. Low (<30%), borderline (30–35%), and high (>35%) IgG avidity indices were found in 104 (22.2%), 30 (6.4%), and 305 (71.4%), respectively. A total of 12 cases had a positive PCR test for amniotic fluids of the prenatal amniocentesis or at birth, or neonatal blood. Seven of the 12 cases were diagnosed as having congenital T. gondii infection, and they had low IgG avidity indices. Congenital T. gondii infection screening using of IgG avidity and multiplex-nested PCR methods for pregnant women with a positive test for T. gondii antibody plus a positive or equivocal test for T. gondii IgM was useful for detecting a high-risk pregnancy and diagnosing congenital T. gondii infection.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>30824301</pmid><doi>10.1016/j.jiac.2019.01.009</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-9839-2214</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2019-06, Vol.25 (6), p.427-430 |
| issn | 1341-321X 1437-7780 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Congenital toxoplasmosis IgG avidity Polymerase chain reaction Prenatal diagnosis Toxoplasma |
| title | A cohort study of maternal screening for congenital Toxoplasma gondii infection: 12 years' experience |
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