Zein/gelatin/nanohydroxyapatite nanofibrous scaffolds are biocompatible and promote osteogenic differentiation of human periodontal ligament stem cells
In bone tissue engineering, it is important for biomaterials to promote the osteogenic differentiation of stem cells to achieve tissue regeneration. Therefore, it is critical to develop biomaterials with excellent cytocompatibility and osteoinductive ability. In our previous study, we found a zein/g...
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| Veröffentlicht in: | Biomaterials science 2019-04, Vol.7 (5), p.1973-1983 |
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| container_end_page | 1983 |
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| container_issue | 5 |
| container_start_page | 1973 |
| container_title | Biomaterials science |
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| creator | Ou, Qianmin Miao, Yingling Yang, Fanqiao Lin, Xuefeng Zhang, Li-Ming Wang, Yan |
| description | In bone tissue engineering, it is important for biomaterials to promote the osteogenic differentiation of stem cells to achieve tissue regeneration. Therefore, it is critical to develop biomaterials with excellent cytocompatibility and osteoinductive ability. In our previous study, we found a zein/gelatin electrospinning scaffold with good biocompatibility, but low osteoinductive ability for human periodontal ligament stem cells (hPDLSCs). Therefore, herein, we fabricated novel zein/gelatin/nanohydroxyapatite (zein/gelatin/nHAp) nanofibrous membranes to overcome the drawbacks of the zein/gelatin scaffold. The results showed that the surface wettability of the zein/gelatin/nHAp nanofiber membranes was increased. Moreover, the inclusion of nHAp facilitated the attachment, proliferation, and osteogenic differentiation of hPDLSCs. Overall, the zein/gelatin/nHAp nanofiber membranes showed good biocompatibility and osteoinductive activity for hPDLSCs
in vitro
and
in vivo
; this suggested potential applications of these membranes in bone tissue engineering.
In bone tissue engineering, it is important for biomaterials to promote the osteogenic differentiation of stem cells to achieve tissue regeneration. |
| doi_str_mv | 10.1039/c8bm01653d |
| format | Article |
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in vitro
and
in vivo
; this suggested potential applications of these membranes in bone tissue engineering.
In bone tissue engineering, it is important for biomaterials to promote the osteogenic differentiation of stem cells to achieve tissue regeneration.</description><identifier>ISSN: 2047-4830</identifier><identifier>EISSN: 2047-4849</identifier><identifier>DOI: 10.1039/c8bm01653d</identifier><identifier>PMID: 30820493</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Biocompatibility ; Biomedical materials ; Bones ; Differentiation (biology) ; Gelatin ; Human performance ; Membranes ; Nanofibers ; Regeneration ; Scaffolds ; Stem cells ; Tissue engineering ; Wettability ; Zein</subject><ispartof>Biomaterials science, 2019-04, Vol.7 (5), p.1973-1983</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-48bc0e35eaf6fa5c8ebb2bda5e9631f72f5eb1af9ca1cc2425899ab3b43629a93</citedby><cites>FETCH-LOGICAL-c480t-48bc0e35eaf6fa5c8ebb2bda5e9631f72f5eb1af9ca1cc2425899ab3b43629a93</cites><orcidid>0000-0002-7645-0812 ; 0000-0002-3192-9475 ; 0000-0001-6384-353X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30820493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ou, Qianmin</creatorcontrib><creatorcontrib>Miao, Yingling</creatorcontrib><creatorcontrib>Yang, Fanqiao</creatorcontrib><creatorcontrib>Lin, Xuefeng</creatorcontrib><creatorcontrib>Zhang, Li-Ming</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><title>Zein/gelatin/nanohydroxyapatite nanofibrous scaffolds are biocompatible and promote osteogenic differentiation of human periodontal ligament stem cells</title><title>Biomaterials science</title><addtitle>Biomater Sci</addtitle><description>In bone tissue engineering, it is important for biomaterials to promote the osteogenic differentiation of stem cells to achieve tissue regeneration. Therefore, it is critical to develop biomaterials with excellent cytocompatibility and osteoinductive ability. In our previous study, we found a zein/gelatin electrospinning scaffold with good biocompatibility, but low osteoinductive ability for human periodontal ligament stem cells (hPDLSCs). Therefore, herein, we fabricated novel zein/gelatin/nanohydroxyapatite (zein/gelatin/nHAp) nanofibrous membranes to overcome the drawbacks of the zein/gelatin scaffold. The results showed that the surface wettability of the zein/gelatin/nHAp nanofiber membranes was increased. Moreover, the inclusion of nHAp facilitated the attachment, proliferation, and osteogenic differentiation of hPDLSCs. Overall, the zein/gelatin/nHAp nanofiber membranes showed good biocompatibility and osteoinductive activity for hPDLSCs
in vitro
and
in vivo
; this suggested potential applications of these membranes in bone tissue engineering.
In bone tissue engineering, it is important for biomaterials to promote the osteogenic differentiation of stem cells to achieve tissue regeneration.</description><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Bones</subject><subject>Differentiation (biology)</subject><subject>Gelatin</subject><subject>Human performance</subject><subject>Membranes</subject><subject>Nanofibers</subject><subject>Regeneration</subject><subject>Scaffolds</subject><subject>Stem cells</subject><subject>Tissue engineering</subject><subject>Wettability</subject><subject>Zein</subject><issn>2047-4830</issn><issn>2047-4849</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkU2LFDEQhoMo7rLuxbsS8CLCuPnoj-Tojp-w4kUvXppKujKbpZOMSTc4v8S_a9pZRzCXClVPFW_VS8hTzl5zJvWVVSYw3rVyfEDOBWv6TaMa_fD0l-yMXJZyx-rre806_picSaZqWctz8us7-ni1wwnmGiPEdHsYc_p5gH3NzEjXlPMmp6XQYsG5NI2FQkZqfLIprJiZkEIc6T6nkGpPKjOmHUZv6eidw4xx9pVLkSZHb5cAke4x-zSmOMNEJ7-DUBla-wK1OE3lCXnkYCp4eR8vyLf3775uP25uvnz4tH1zs7GNYnPdz1iGskVwnYPWKjRGmBFa1J3krheuRcPBaQvcWtGIVmkNRppGdkKDlhfk5XFu1f5jwTIPwZdVAUSsKw-Cq77lSqqmoi_-Q-_SkmNVNwjBJVsP3lbq1ZGyOZWS0Q377APkw8DZsDo2bNX15z-Ova3w8_uRiwk4ntC__lTg2RHIxZ6q_yyXvwFyj594</recordid><startdate>20190423</startdate><enddate>20190423</enddate><creator>Ou, Qianmin</creator><creator>Miao, Yingling</creator><creator>Yang, Fanqiao</creator><creator>Lin, Xuefeng</creator><creator>Zhang, Li-Ming</creator><creator>Wang, Yan</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7645-0812</orcidid><orcidid>https://orcid.org/0000-0002-3192-9475</orcidid><orcidid>https://orcid.org/0000-0001-6384-353X</orcidid></search><sort><creationdate>20190423</creationdate><title>Zein/gelatin/nanohydroxyapatite nanofibrous scaffolds are biocompatible and promote osteogenic differentiation of human periodontal ligament stem cells</title><author>Ou, Qianmin ; Miao, Yingling ; Yang, Fanqiao ; Lin, Xuefeng ; Zhang, Li-Ming ; Wang, Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-48bc0e35eaf6fa5c8ebb2bda5e9631f72f5eb1af9ca1cc2425899ab3b43629a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Bones</topic><topic>Differentiation (biology)</topic><topic>Gelatin</topic><topic>Human performance</topic><topic>Membranes</topic><topic>Nanofibers</topic><topic>Regeneration</topic><topic>Scaffolds</topic><topic>Stem cells</topic><topic>Tissue engineering</topic><topic>Wettability</topic><topic>Zein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ou, Qianmin</creatorcontrib><creatorcontrib>Miao, Yingling</creatorcontrib><creatorcontrib>Yang, Fanqiao</creatorcontrib><creatorcontrib>Lin, Xuefeng</creatorcontrib><creatorcontrib>Zhang, Li-Ming</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ou, Qianmin</au><au>Miao, Yingling</au><au>Yang, Fanqiao</au><au>Lin, Xuefeng</au><au>Zhang, Li-Ming</au><au>Wang, Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zein/gelatin/nanohydroxyapatite nanofibrous scaffolds are biocompatible and promote osteogenic differentiation of human periodontal ligament stem cells</atitle><jtitle>Biomaterials science</jtitle><addtitle>Biomater Sci</addtitle><date>2019-04-23</date><risdate>2019</risdate><volume>7</volume><issue>5</issue><spage>1973</spage><epage>1983</epage><pages>1973-1983</pages><issn>2047-4830</issn><eissn>2047-4849</eissn><abstract>In bone tissue engineering, it is important for biomaterials to promote the osteogenic differentiation of stem cells to achieve tissue regeneration. Therefore, it is critical to develop biomaterials with excellent cytocompatibility and osteoinductive ability. In our previous study, we found a zein/gelatin electrospinning scaffold with good biocompatibility, but low osteoinductive ability for human periodontal ligament stem cells (hPDLSCs). Therefore, herein, we fabricated novel zein/gelatin/nanohydroxyapatite (zein/gelatin/nHAp) nanofibrous membranes to overcome the drawbacks of the zein/gelatin scaffold. The results showed that the surface wettability of the zein/gelatin/nHAp nanofiber membranes was increased. Moreover, the inclusion of nHAp facilitated the attachment, proliferation, and osteogenic differentiation of hPDLSCs. Overall, the zein/gelatin/nHAp nanofiber membranes showed good biocompatibility and osteoinductive activity for hPDLSCs
in vitro
and
in vivo
; this suggested potential applications of these membranes in bone tissue engineering.
In bone tissue engineering, it is important for biomaterials to promote the osteogenic differentiation of stem cells to achieve tissue regeneration.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>30820493</pmid><doi>10.1039/c8bm01653d</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-7645-0812</orcidid><orcidid>https://orcid.org/0000-0002-3192-9475</orcidid><orcidid>https://orcid.org/0000-0001-6384-353X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2047-4830 |
| ispartof | Biomaterials science, 2019-04, Vol.7 (5), p.1973-1983 |
| issn | 2047-4830 2047-4849 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2187518384 |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Biocompatibility Biomedical materials Bones Differentiation (biology) Gelatin Human performance Membranes Nanofibers Regeneration Scaffolds Stem cells Tissue engineering Wettability Zein |
| title | Zein/gelatin/nanohydroxyapatite nanofibrous scaffolds are biocompatible and promote osteogenic differentiation of human periodontal ligament stem cells |
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