Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer
Objective To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC‐HE) among individuals with an initial oral/oropharyngeal cancer. Materials and Methods Mass screening data from Taiwan (2004–2009) included individuals who were ≥18 years old and smoked cigarettes and/o...
Gespeichert in:
| Veröffentlicht in: | Oral diseases 2019-05, Vol.25 (4), p.1067-1075 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1075 |
|---|---|
| container_issue | 4 |
| container_start_page | 1067 |
| container_title | Oral diseases |
| container_volume | 25 |
| creator | Su, William Wang‐Yu Chuang, Shu‐Lin Yen, Amy Ming‐Fang Chen, Sam Li‐Sheng Fann, Jean Ching‐Yuan Chiu, Sherry Yueh‐Hsia Chiu, Han‐Mo Su, Chiu‐Wen Hsu, Chen‐Yang Chen, Mu‐Kuan Chen, Hsiu‐Hsi Wang, Cheng‐Ping Lee, Yi‐Chia |
| description | Objective
To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC‐HE) among individuals with an initial oral/oropharyngeal cancer.
Materials and Methods
Mass screening data from Taiwan (2004–2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC‐HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI).
Results
One hundred and fifty‐eight out of 4,494 subjects with oral cancer developed SPC‐HE (incidence rate: 6.47 per 1,000 person‐years). Relative to patients with primary cancers in the lip, the risk of an SPC‐HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95% CI: 4.72–84.55), floor of mouth (aRR: 12.13, 95% CI: 2.67–55.15), and hard palate (aRR: 7.31, 95% CI: 1.65–32.37), but not in patients with cancers in tongue (aRR: 3.67, 95% CI: 0.89–15.17) or gum (aRR: 3.99, 95% CI: 0.92–17.35). Regression analyses also showed the risk of an SPC‐HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95% CI: 1.10–2.48).
Conclusions
Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC‐HE. |
| doi_str_mv | 10.1111/odi.13080 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2187514897</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2187514897</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4190-5daae6c017ed943da23ff5e5924960ec3d4b4854fb1e0fe1dd2fd2d3e31cece33</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMotlYP_gFZ8KKHbfPZbo5SP6FQEAVvIU0mdut2s266SP-9abftQTCHZGbyzMvMi9AlwX0Sz8DbvE8YzvAR6pIhJinOqDiOMRM8FZR9dNBZCAuMyUgyeoo6kaUky1gXmdc8fCXO14lOAhhf2qSq86Wu18l8XflqHqPyE3SR6PgFYVPZpkaXBmKXW23uMsnLfJXH-r7b1wfoHJ04XQS42L099P748DZ-TifTp5fx3SQ1nEicCqs1DE0cEqzkzGrKnBMgJOVyiMEwy2c8E9zNCGAHxFrqLLUMGDFggLEeuml1q9p_NxBWapkHA0WhS_BNUHHlkSA8k6OIXv9BF76pyzidohRLKSjNaKRuW8rUPoQanNptpwhWG-dVdF5tnY_s1U6xmS3BHsi91REYtMBPXsD6fyU1vX9pJX8B5GSN8Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2209952282</pqid></control><display><type>article</type><title>Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Su, William Wang‐Yu ; Chuang, Shu‐Lin ; Yen, Amy Ming‐Fang ; Chen, Sam Li‐Sheng ; Fann, Jean Ching‐Yuan ; Chiu, Sherry Yueh‐Hsia ; Chiu, Han‐Mo ; Su, Chiu‐Wen ; Hsu, Chen‐Yang ; Chen, Mu‐Kuan ; Chen, Hsiu‐Hsi ; Wang, Cheng‐Ping ; Lee, Yi‐Chia</creator><creatorcontrib>Su, William Wang‐Yu ; Chuang, Shu‐Lin ; Yen, Amy Ming‐Fang ; Chen, Sam Li‐Sheng ; Fann, Jean Ching‐Yuan ; Chiu, Sherry Yueh‐Hsia ; Chiu, Han‐Mo ; Su, Chiu‐Wen ; Hsu, Chen‐Yang ; Chen, Mu‐Kuan ; Chen, Hsiu‐Hsi ; Wang, Cheng‐Ping ; Lee, Yi‐Chia</creatorcontrib><description>Objective
To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC‐HE) among individuals with an initial oral/oropharyngeal cancer.
Materials and Methods
Mass screening data from Taiwan (2004–2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC‐HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI).
Results
One hundred and fifty‐eight out of 4,494 subjects with oral cancer developed SPC‐HE (incidence rate: 6.47 per 1,000 person‐years). Relative to patients with primary cancers in the lip, the risk of an SPC‐HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95% CI: 4.72–84.55), floor of mouth (aRR: 12.13, 95% CI: 2.67–55.15), and hard palate (aRR: 7.31, 95% CI: 1.65–32.37), but not in patients with cancers in tongue (aRR: 3.67, 95% CI: 0.89–15.17) or gum (aRR: 3.99, 95% CI: 0.92–17.35). Regression analyses also showed the risk of an SPC‐HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95% CI: 1.10–2.48).
Conclusions
Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC‐HE.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.13080</identifier><identifier>PMID: 30821883</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; cancer screening ; Carcinoma, Squamous Cell - epidemiology ; Cigarettes ; Dentistry ; Esophageal cancer ; Esophageal Neoplasms - epidemiology ; Esophageal Neoplasms - pathology ; Esophagus ; Female ; Health risk assessment ; Humans ; hypopharyngeal cancer ; Hypopharyngeal Neoplasms - epidemiology ; Hypopharyngeal Neoplasms - pathology ; Hypopharynx ; Lip ; Male ; Middle Aged ; Mouth Neoplasms - epidemiology ; Mouth Neoplasms - pathology ; Neoplasms, Second Primary - epidemiology ; Neoplasms, Second Primary - pathology ; Oral cancer ; oral/oropharyngeal cancer ; Oropharyngeal cancer ; Oropharynx ; Palate ; second primary cancer ; Taiwan ; Throat cancer</subject><ispartof>Oral diseases, 2019-05, Vol.25 (4), p.1067-1075</ispartof><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved</rights><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.</rights><rights>Copyright © 2019 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4190-5daae6c017ed943da23ff5e5924960ec3d4b4854fb1e0fe1dd2fd2d3e31cece33</citedby><cites>FETCH-LOGICAL-c4190-5daae6c017ed943da23ff5e5924960ec3d4b4854fb1e0fe1dd2fd2d3e31cece33</cites><orcidid>0000-0002-8160-1216 ; 0000-0002-0628-8768 ; 0000-0001-9750-3015 ; 0000-0003-1640-2920</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.13080$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.13080$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30821883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, William Wang‐Yu</creatorcontrib><creatorcontrib>Chuang, Shu‐Lin</creatorcontrib><creatorcontrib>Yen, Amy Ming‐Fang</creatorcontrib><creatorcontrib>Chen, Sam Li‐Sheng</creatorcontrib><creatorcontrib>Fann, Jean Ching‐Yuan</creatorcontrib><creatorcontrib>Chiu, Sherry Yueh‐Hsia</creatorcontrib><creatorcontrib>Chiu, Han‐Mo</creatorcontrib><creatorcontrib>Su, Chiu‐Wen</creatorcontrib><creatorcontrib>Hsu, Chen‐Yang</creatorcontrib><creatorcontrib>Chen, Mu‐Kuan</creatorcontrib><creatorcontrib>Chen, Hsiu‐Hsi</creatorcontrib><creatorcontrib>Wang, Cheng‐Ping</creatorcontrib><creatorcontrib>Lee, Yi‐Chia</creatorcontrib><title>Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objective
To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC‐HE) among individuals with an initial oral/oropharyngeal cancer.
Materials and Methods
Mass screening data from Taiwan (2004–2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC‐HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI).
Results
One hundred and fifty‐eight out of 4,494 subjects with oral cancer developed SPC‐HE (incidence rate: 6.47 per 1,000 person‐years). Relative to patients with primary cancers in the lip, the risk of an SPC‐HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95% CI: 4.72–84.55), floor of mouth (aRR: 12.13, 95% CI: 2.67–55.15), and hard palate (aRR: 7.31, 95% CI: 1.65–32.37), but not in patients with cancers in tongue (aRR: 3.67, 95% CI: 0.89–15.17) or gum (aRR: 3.99, 95% CI: 0.92–17.35). Regression analyses also showed the risk of an SPC‐HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95% CI: 1.10–2.48).
Conclusions
Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC‐HE.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>cancer screening</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Cigarettes</subject><subject>Dentistry</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - epidemiology</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophagus</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>hypopharyngeal cancer</subject><subject>Hypopharyngeal Neoplasms - epidemiology</subject><subject>Hypopharyngeal Neoplasms - pathology</subject><subject>Hypopharynx</subject><subject>Lip</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - epidemiology</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasms, Second Primary - epidemiology</subject><subject>Neoplasms, Second Primary - pathology</subject><subject>Oral cancer</subject><subject>oral/oropharyngeal cancer</subject><subject>Oropharyngeal cancer</subject><subject>Oropharynx</subject><subject>Palate</subject><subject>second primary cancer</subject><subject>Taiwan</subject><subject>Throat cancer</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMotlYP_gFZ8KKHbfPZbo5SP6FQEAVvIU0mdut2s266SP-9abftQTCHZGbyzMvMi9AlwX0Sz8DbvE8YzvAR6pIhJinOqDiOMRM8FZR9dNBZCAuMyUgyeoo6kaUky1gXmdc8fCXO14lOAhhf2qSq86Wu18l8XflqHqPyE3SR6PgFYVPZpkaXBmKXW23uMsnLfJXH-r7b1wfoHJ04XQS42L099P748DZ-TifTp5fx3SQ1nEicCqs1DE0cEqzkzGrKnBMgJOVyiMEwy2c8E9zNCGAHxFrqLLUMGDFggLEeuml1q9p_NxBWapkHA0WhS_BNUHHlkSA8k6OIXv9BF76pyzidohRLKSjNaKRuW8rUPoQanNptpwhWG-dVdF5tnY_s1U6xmS3BHsi91REYtMBPXsD6fyU1vX9pJX8B5GSN8Q</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Su, William Wang‐Yu</creator><creator>Chuang, Shu‐Lin</creator><creator>Yen, Amy Ming‐Fang</creator><creator>Chen, Sam Li‐Sheng</creator><creator>Fann, Jean Ching‐Yuan</creator><creator>Chiu, Sherry Yueh‐Hsia</creator><creator>Chiu, Han‐Mo</creator><creator>Su, Chiu‐Wen</creator><creator>Hsu, Chen‐Yang</creator><creator>Chen, Mu‐Kuan</creator><creator>Chen, Hsiu‐Hsi</creator><creator>Wang, Cheng‐Ping</creator><creator>Lee, Yi‐Chia</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8160-1216</orcidid><orcidid>https://orcid.org/0000-0002-0628-8768</orcidid><orcidid>https://orcid.org/0000-0001-9750-3015</orcidid><orcidid>https://orcid.org/0000-0003-1640-2920</orcidid></search><sort><creationdate>201905</creationdate><title>Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer</title><author>Su, William Wang‐Yu ; Chuang, Shu‐Lin ; Yen, Amy Ming‐Fang ; Chen, Sam Li‐Sheng ; Fann, Jean Ching‐Yuan ; Chiu, Sherry Yueh‐Hsia ; Chiu, Han‐Mo ; Su, Chiu‐Wen ; Hsu, Chen‐Yang ; Chen, Mu‐Kuan ; Chen, Hsiu‐Hsi ; Wang, Cheng‐Ping ; Lee, Yi‐Chia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4190-5daae6c017ed943da23ff5e5924960ec3d4b4854fb1e0fe1dd2fd2d3e31cece33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>cancer screening</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Cigarettes</topic><topic>Dentistry</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - epidemiology</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophagus</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>hypopharyngeal cancer</topic><topic>Hypopharyngeal Neoplasms - epidemiology</topic><topic>Hypopharyngeal Neoplasms - pathology</topic><topic>Hypopharynx</topic><topic>Lip</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - epidemiology</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasms, Second Primary - epidemiology</topic><topic>Neoplasms, Second Primary - pathology</topic><topic>Oral cancer</topic><topic>oral/oropharyngeal cancer</topic><topic>Oropharyngeal cancer</topic><topic>Oropharynx</topic><topic>Palate</topic><topic>second primary cancer</topic><topic>Taiwan</topic><topic>Throat cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, William Wang‐Yu</creatorcontrib><creatorcontrib>Chuang, Shu‐Lin</creatorcontrib><creatorcontrib>Yen, Amy Ming‐Fang</creatorcontrib><creatorcontrib>Chen, Sam Li‐Sheng</creatorcontrib><creatorcontrib>Fann, Jean Ching‐Yuan</creatorcontrib><creatorcontrib>Chiu, Sherry Yueh‐Hsia</creatorcontrib><creatorcontrib>Chiu, Han‐Mo</creatorcontrib><creatorcontrib>Su, Chiu‐Wen</creatorcontrib><creatorcontrib>Hsu, Chen‐Yang</creatorcontrib><creatorcontrib>Chen, Mu‐Kuan</creatorcontrib><creatorcontrib>Chen, Hsiu‐Hsi</creatorcontrib><creatorcontrib>Wang, Cheng‐Ping</creatorcontrib><creatorcontrib>Lee, Yi‐Chia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, William Wang‐Yu</au><au>Chuang, Shu‐Lin</au><au>Yen, Amy Ming‐Fang</au><au>Chen, Sam Li‐Sheng</au><au>Fann, Jean Ching‐Yuan</au><au>Chiu, Sherry Yueh‐Hsia</au><au>Chiu, Han‐Mo</au><au>Su, Chiu‐Wen</au><au>Hsu, Chen‐Yang</au><au>Chen, Mu‐Kuan</au><au>Chen, Hsiu‐Hsi</au><au>Wang, Cheng‐Ping</au><au>Lee, Yi‐Chia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2019-05</date><risdate>2019</risdate><volume>25</volume><issue>4</issue><spage>1067</spage><epage>1075</epage><pages>1067-1075</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Objective
To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC‐HE) among individuals with an initial oral/oropharyngeal cancer.
Materials and Methods
Mass screening data from Taiwan (2004–2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC‐HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI).
Results
One hundred and fifty‐eight out of 4,494 subjects with oral cancer developed SPC‐HE (incidence rate: 6.47 per 1,000 person‐years). Relative to patients with primary cancers in the lip, the risk of an SPC‐HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95% CI: 4.72–84.55), floor of mouth (aRR: 12.13, 95% CI: 2.67–55.15), and hard palate (aRR: 7.31, 95% CI: 1.65–32.37), but not in patients with cancers in tongue (aRR: 3.67, 95% CI: 0.89–15.17) or gum (aRR: 3.99, 95% CI: 0.92–17.35). Regression analyses also showed the risk of an SPC‐HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95% CI: 1.10–2.48).
Conclusions
Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC‐HE.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30821883</pmid><doi>10.1111/odi.13080</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8160-1216</orcidid><orcidid>https://orcid.org/0000-0002-0628-8768</orcidid><orcidid>https://orcid.org/0000-0001-9750-3015</orcidid><orcidid>https://orcid.org/0000-0003-1640-2920</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1354-523X |
| ispartof | Oral diseases, 2019-05, Vol.25 (4), p.1067-1075 |
| issn | 1354-523X 1601-0825 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2187514897 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adult Aged Aged, 80 and over cancer screening Carcinoma, Squamous Cell - epidemiology Cigarettes Dentistry Esophageal cancer Esophageal Neoplasms - epidemiology Esophageal Neoplasms - pathology Esophagus Female Health risk assessment Humans hypopharyngeal cancer Hypopharyngeal Neoplasms - epidemiology Hypopharyngeal Neoplasms - pathology Hypopharynx Lip Male Middle Aged Mouth Neoplasms - epidemiology Mouth Neoplasms - pathology Neoplasms, Second Primary - epidemiology Neoplasms, Second Primary - pathology Oral cancer oral/oropharyngeal cancer Oropharyngeal cancer Oropharynx Palate second primary cancer Taiwan Throat cancer |
| title | Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T16%3A29%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Risk%20for%20a%20second%20primary%20hypopharyngeal%20and%20esophageal%20cancer%20after%20an%20initial%20primary%20oral%20cancer&rft.jtitle=Oral%20diseases&rft.au=Su,%20William%20Wang%E2%80%90Yu&rft.date=2019-05&rft.volume=25&rft.issue=4&rft.spage=1067&rft.epage=1075&rft.pages=1067-1075&rft.issn=1354-523X&rft.eissn=1601-0825&rft_id=info:doi/10.1111/odi.13080&rft_dat=%3Cproquest_cross%3E2187514897%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2209952282&rft_id=info:pmid/30821883&rfr_iscdi=true |