Resveratrol induces cell death through ROS‑dependent downregulation of Notch1/PTEN/Akt signaling in ovarian cancer cells

Resveratrol, a natural polyphenol compound, has been reported to exert anticancer activity in various cancer cells. The present study investigated the effect and underlying mechanisms of resveratrol in the human ovarian cancer cell lines, A2780 and SKOV3. Treatment with resveratrol induced apoptotic...

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Veröffentlicht in:	Molecular medicine reports 2019-04, Vol.19 (4), p.3353-3360
Hauptverfasser:	Kim, Thae Hyun, Park, Ji Hye, Woo, Jae Suk
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine AKT protein Antioxidants Antioxidants (Nutrients) Antitumor activity Apoptosis Biochemistry Cancer cells Cancer therapies Cancer treatment Caspase Caspase-3 Cell death Cellular signal transduction Cytochrome Drug resistance EDTA Immunoglobulins Membranes Notch1 protein Ovarian cancer Phosphatases PTEN protein Reactive oxygen species Resveratrol Software Tensin Transfection Tumor cell lines
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