Hypersynchronicity in the default mode-like network in a neurodevelopmental animal model with relevance for schizophrenia

•Maternal immune activation (Poly I:C) results in Weight Loss or Weight Gain in dams.•Poly I:C WL offspring have hypersynchronicity in default mode-like network (DMN).•Attenuated NMDAR antagonist response is most pronounced in Poly I:C WG offspring.•Poly I:C offspring exhibit anxiety.•Functional con...

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Veröffentlicht in:	Behavioural brain research 2019-05, Vol.364, p.303-316
Hauptverfasser:	Missault, Stephan, Anckaerts, Cynthia, Ahmadoun, Soumaya, Blockx, Ines, Barbier, Michaël, Bielen, Kenny, Shah, Disha, Kumar-Singh, Samir, De Vos, Winnok H., Van der Linden, Annemie, Dedeurwaerdere, Stefanie, Verhoye, Marleen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autism spectrum disorder Behavior, Animal - physiology Biomarker Brain - drug effects Diffusion MRI Disease Models, Animal Female Immunity, Active - immunology Immunity, Active - physiology Magnetic Resonance Imaging - methods Male MK-801 Motor Activity - drug effects Poly I-C - pharmacology Pregnancy Prenatal Exposure Delayed Effects - metabolism Prenatal Exposure Delayed Effects - physiopathology Prenatal immune activation Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Rest Schizophrenia - etiology Schizophrenia - immunology Schizophrenia - metabolism Weight Gain Weight Loss
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