Directed C3-Alkoxymethylation of Indole via Three-Component Cascade Reaction

Directed C3-Alkoxymethylation of Indole via Three-Component Cascade Reaction

An efficient and regioselective C3-alkoxymethylation of indoles has been developed with aldehydes and alcohols via three-component cascade reaction under transition-metal free conditions. This method allows for rapid access to a variety of C3-alkoxymethylaed free (N–H) indole in up to 98% yield with...

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Veröffentlicht in:Organic letters 2019-04, Vol.21 (7), p.2081-2084
Hauptverfasser: Pi, Chao, Yin, Xiaohang, Cui, Xiuling, Ma, Yuwen, Wu, Yangjie
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container_title Organic letters
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creator Pi, Chao
Yin, Xiaohang
Cui, Xiuling
Ma, Yuwen
Wu, Yangjie
description An efficient and regioselective C3-alkoxymethylation of indoles has been developed with aldehydes and alcohols via three-component cascade reaction under transition-metal free conditions. This method allows for rapid access to a variety of C3-alkoxymethylaed free (N–H) indole in up to 98% yield with excellent regioselectivity. The titled products are useful building blocks in organic synthesis.
doi_str_mv 10.1021/acs.orglett.9b00357
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title Directed C3-Alkoxymethylation of Indole via Three-Component Cascade Reaction
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