Polygenic Risk Scores That Predict Common Diseases Using Millions of Single Nucleotide Polymorphisms: Is More, Better?

In recent studies, this increased risk is claimed to be similar to conditions associated with known causal genetic mutations. [...]the argument goes, it is time to start thinking about implementing PRSs in routine clinical care (1, 2). [...]another study (5) also investigated polygenic risk predicti...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2019-05, Vol.65 (5), p.609-611
Hauptverfasser:	Janssens, A Cecile JW, Joyner, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Cardiovascular disease Coronary vessels Genome-Wide Association Study Genomes Health risk assessment Humans Multifactorial Inheritance Mutation Polymorphism, Single Nucleotide Population Predictions Researchers Risk analysis Risk factors Single-nucleotide polymorphism Statistical analysis Studies
Online-Zugang:	Volltext
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