Long non-coding RNA DNM3OS promotes tumor progression and EMT in gastric cancer by associating with Snail
Long non-coding RNAs (lncRNAs) act as tumor suppressors or oncogenes in tumor development and progression. In the present study, we explored the expression and biological role of the lncRNA DNM3OS in gastric cancer (GC). We observed that DNM3OS was upregulated in GC tissues and cell lines, and high...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2019-03, Vol.511 (1), p.57-62 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Wang, Shuchang Ni, Bo Zhang, Zizhen Wang, Chaojie Wo, Lulu Zhou, Cixiang Zhao, Qian Zhao, Enhao |
| description | Long non-coding RNAs (lncRNAs) act as tumor suppressors or oncogenes in tumor development and progression. In the present study, we explored the expression and biological role of the lncRNA DNM3OS in gastric cancer (GC). We observed that DNM3OS was upregulated in GC tissues and cell lines, and high DNM3OS expression was correlated with malignant features and served as an indicator of a poor prognosis for GC patients. DNM3OS knockdown inhibited the proliferation of GC cells, and reduced DNM3OS suppressed tumor growth in vivo. Moreover, DNM3OS depletion inhibited the migration and invasion of GC cells through the suppression of the Snail-mediated epithelial-mesenchymal transition (EMT). In conclusion, we demonstrated that DNM3OS serves as an oncogenic lncRNA in GC, and we implicated DNM3OS as a promising prognostic factor and a potential therapeutic target for GC patients.
•DNM3OS expression was elevated in GC patients tissues.•Higher expression of DNM3OS was associated with poor survival of GC patients.•DNM3OS promotes malignancy in GC cells.•DNM3OS depletion inhibited the invasion of GC cells through the suppression of the Snail-mediated EMT. |
| doi_str_mv | 10.1016/j.bbrc.2019.02.030 |
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•DNM3OS expression was elevated in GC patients tissues.•Higher expression of DNM3OS was associated with poor survival of GC patients.•DNM3OS promotes malignancy in GC cells.•DNM3OS depletion inhibited the invasion of GC cells through the suppression of the Snail-mediated EMT.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2019.02.030</identifier><identifier>PMID: 30770102</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cell Line, Tumor ; Disease Progression ; DNM3OS ; EMT ; Epithelial-Mesenchymal Transition ; Gastric cancer ; Gene Expression Regulation, Neoplastic ; Humans ; Mice, Nude ; Neoplasm Invasiveness - genetics ; Neoplasm Invasiveness - pathology ; RNA, Long Noncoding - genetics ; Snail ; Snail Family Transcription Factors - genetics ; Stomach Neoplasms - genetics ; Stomach Neoplasms - pathology</subject><ispartof>Biochemical and biophysical research communications, 2019-03, Vol.511 (1), p.57-62</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-f0c11cf1d680ee9941271fec07ab8f22684e53448c0f7c637c3a41c92dc300323</citedby><cites>FETCH-LOGICAL-c356t-f0c11cf1d680ee9941271fec07ab8f22684e53448c0f7c637c3a41c92dc300323</cites><orcidid>0000-0003-1112-0043 ; 0000-0001-6731-2891</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X19302177$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30770102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Shuchang</creatorcontrib><creatorcontrib>Ni, Bo</creatorcontrib><creatorcontrib>Zhang, Zizhen</creatorcontrib><creatorcontrib>Wang, Chaojie</creatorcontrib><creatorcontrib>Wo, Lulu</creatorcontrib><creatorcontrib>Zhou, Cixiang</creatorcontrib><creatorcontrib>Zhao, Qian</creatorcontrib><creatorcontrib>Zhao, Enhao</creatorcontrib><title>Long non-coding RNA DNM3OS promotes tumor progression and EMT in gastric cancer by associating with Snail</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Long non-coding RNAs (lncRNAs) act as tumor suppressors or oncogenes in tumor development and progression. In the present study, we explored the expression and biological role of the lncRNA DNM3OS in gastric cancer (GC). We observed that DNM3OS was upregulated in GC tissues and cell lines, and high DNM3OS expression was correlated with malignant features and served as an indicator of a poor prognosis for GC patients. DNM3OS knockdown inhibited the proliferation of GC cells, and reduced DNM3OS suppressed tumor growth in vivo. Moreover, DNM3OS depletion inhibited the migration and invasion of GC cells through the suppression of the Snail-mediated epithelial-mesenchymal transition (EMT). In conclusion, we demonstrated that DNM3OS serves as an oncogenic lncRNA in GC, and we implicated DNM3OS as a promising prognostic factor and a potential therapeutic target for GC patients.
•DNM3OS expression was elevated in GC patients tissues.•Higher expression of DNM3OS was associated with poor survival of GC patients.•DNM3OS promotes malignancy in GC cells.•DNM3OS depletion inhibited the invasion of GC cells through the suppression of the Snail-mediated EMT.</description><subject>Animals</subject><subject>Cell Line, Tumor</subject><subject>Disease Progression</subject><subject>DNM3OS</subject><subject>EMT</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Gastric cancer</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Mice, Nude</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>RNA, Long Noncoding - genetics</subject><subject>Snail</subject><subject>Snail Family Transcription Factors - genetics</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - pathology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EokvLC3BAPnJJmLFTJ5G4VKUUpG0rtUXiZjmTyeLVxi52FtS3b6ItHDnNjPTNr5lPiHcIJQKaj9uy6xKVCrAtQZWg4YVYIbRQKITqpVgBgClUiz-OxJuctwCIlWlfiyMNdQ0IaiX8OoaNDDEUFHs_t7fXZ_Lz9ZW-uZMPKY5x4iyn_RjTMm4S5-xjkC708uLqXvogNy5PyZMkF4iT7B6lyzmSd9MS98dPP-VdcH53Il4Nbpf57XM9Ft-_XNyffy3WN5ffzs_WBelTMxUDECIN2JsGmNu2QlXjwAS165pBKdNUfKqrqiEYajK6Ju0qpFb1pAG00sfiwyF3vvfXnvNkR5-JdzsXOO6zVdgYsziDGVUHlFLMOfFgH5IfXXq0CHZRbLd2UWwX3IKys-J56f1z_r4buf-38tfpDHw6ADx_-dtzspk8z3J6n5gm20f_v_wnkaiL2Q</recordid><startdate>20190326</startdate><enddate>20190326</enddate><creator>Wang, Shuchang</creator><creator>Ni, Bo</creator><creator>Zhang, Zizhen</creator><creator>Wang, Chaojie</creator><creator>Wo, Lulu</creator><creator>Zhou, Cixiang</creator><creator>Zhao, Qian</creator><creator>Zhao, Enhao</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1112-0043</orcidid><orcidid>https://orcid.org/0000-0001-6731-2891</orcidid></search><sort><creationdate>20190326</creationdate><title>Long non-coding RNA DNM3OS promotes tumor progression and EMT in gastric cancer by associating with Snail</title><author>Wang, Shuchang ; Ni, Bo ; Zhang, Zizhen ; Wang, Chaojie ; Wo, Lulu ; Zhou, Cixiang ; Zhao, Qian ; Zhao, Enhao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-f0c11cf1d680ee9941271fec07ab8f22684e53448c0f7c637c3a41c92dc300323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Cell Line, Tumor</topic><topic>Disease Progression</topic><topic>DNM3OS</topic><topic>EMT</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Gastric cancer</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Mice, Nude</topic><topic>Neoplasm Invasiveness - genetics</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>RNA, Long Noncoding - genetics</topic><topic>Snail</topic><topic>Snail Family Transcription Factors - genetics</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Shuchang</creatorcontrib><creatorcontrib>Ni, Bo</creatorcontrib><creatorcontrib>Zhang, Zizhen</creatorcontrib><creatorcontrib>Wang, Chaojie</creatorcontrib><creatorcontrib>Wo, Lulu</creatorcontrib><creatorcontrib>Zhou, Cixiang</creatorcontrib><creatorcontrib>Zhao, Qian</creatorcontrib><creatorcontrib>Zhao, Enhao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Shuchang</au><au>Ni, Bo</au><au>Zhang, Zizhen</au><au>Wang, Chaojie</au><au>Wo, Lulu</au><au>Zhou, Cixiang</au><au>Zhao, Qian</au><au>Zhao, Enhao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long non-coding RNA DNM3OS promotes tumor progression and EMT in gastric cancer by associating with Snail</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2019-03-26</date><risdate>2019</risdate><volume>511</volume><issue>1</issue><spage>57</spage><epage>62</epage><pages>57-62</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Long non-coding RNAs (lncRNAs) act as tumor suppressors or oncogenes in tumor development and progression. In the present study, we explored the expression and biological role of the lncRNA DNM3OS in gastric cancer (GC). We observed that DNM3OS was upregulated in GC tissues and cell lines, and high DNM3OS expression was correlated with malignant features and served as an indicator of a poor prognosis for GC patients. DNM3OS knockdown inhibited the proliferation of GC cells, and reduced DNM3OS suppressed tumor growth in vivo. Moreover, DNM3OS depletion inhibited the migration and invasion of GC cells through the suppression of the Snail-mediated epithelial-mesenchymal transition (EMT). In conclusion, we demonstrated that DNM3OS serves as an oncogenic lncRNA in GC, and we implicated DNM3OS as a promising prognostic factor and a potential therapeutic target for GC patients.
•DNM3OS expression was elevated in GC patients tissues.•Higher expression of DNM3OS was associated with poor survival of GC patients.•DNM3OS promotes malignancy in GC cells.•DNM3OS depletion inhibited the invasion of GC cells through the suppression of the Snail-mediated EMT.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30770102</pmid><doi>10.1016/j.bbrc.2019.02.030</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1112-0043</orcidid><orcidid>https://orcid.org/0000-0001-6731-2891</orcidid></addata></record> |
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| subjects | Animals Cell Line, Tumor Disease Progression DNM3OS EMT Epithelial-Mesenchymal Transition Gastric cancer Gene Expression Regulation, Neoplastic Humans Mice, Nude Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology RNA, Long Noncoding - genetics Snail Snail Family Transcription Factors - genetics Stomach Neoplasms - genetics Stomach Neoplasms - pathology |
| title | Long non-coding RNA DNM3OS promotes tumor progression and EMT in gastric cancer by associating with Snail |
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