The Haphazard Pattern in Grade-3 Endometrioid Carcinoma Is Associated with Poor Prognosis and Tumor Lymphocyte Infiltration
The aim of this study was to examine the associations among the haphazard invasive patterns, defined as directionless infiltration into the myometrium; expression of key proteins; tumor infiltrative lymphocytes (TILs); and the prognosis of gade-3 endometrioid carcinoma (G3EC). Between 1990 and 2013,...
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| Veröffentlicht in: | Pathology oncology research 2020-04, Vol.26 (2), p.783-790 |
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| creator | Miyamoto, Morikazu Takano, Masashi Tsuda, Hitoshi Matsuura, Hiroko Sakamoto, Takahiro Takasaki, Kazuki Kato, Kento Soyama, Hiroaki Aoyama, Tadashi Ishibashi, Hiroki Iwahashi, Hideki Furuya, Kenichi |
| description | The aim of this study was to examine the associations among the haphazard invasive patterns, defined as directionless infiltration into the myometrium; expression of key proteins; tumor infiltrative lymphocytes (TILs); and the prognosis of gade-3 endometrioid carcinoma (G3EC). Between 1990 and 2013, patients with G3EC who underwent surgery at our hospital were identified. Invasive patterns were classified into either haphazard, infiltrative, or expansile patterns. The estrogen, progesterone, androgen receptor, cytokeratin 5/6, epidermal growth factor receptor, E-cadherin, snail-2, vimentin, ZEB1, chromogranin A, synaptophysin, MLH1, MSH2, MSH6, and PMS2 levels were evaluated by immunochemical analysis. The degree of strong or weak lymphocyte infiltration (LI) were evaluated using zone formation of LI at the invasive front. Haphazard, infiltrative, and expansile patterns were discovered in 8 (18%), 6 (13%), and 31 (69%) cases, respectively. Cases with the haphazard patterns were diagnosed at a more advanced stage (
p
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| doi_str_mv | 10.1007/s12253-019-00624-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2186619722</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2405673579</sourcerecordid><originalsourceid>FETCH-LOGICAL-c354t-394fc12035a37d9e838b3cc774c3db42196f2f1cb38f5d42f6ee64094b5341fe3</originalsourceid><addsrcrecordid>eNp9kU1rHCEch6W0NGnSL9BDEXrpZVrfZzyGJU0WFrKHzVkcX7KGHd2qQ9n0y9dk0xZyyEnx__x-Kg8AnzD6hhHqvxdMCKcdwrJDSBDW4TfgFHNKOjKg_m3bkzZikosT8KGUe9RCQor34ISiAaNB8lPwe7N18Frvt_pBZwvXulaXIwwRXmVtXUfhZbRpcjWHFCxc6GxCTJOGywIvSkkm6Oos_BXqFq5TynCd011MJRSoo4WbeWpnq8O03yZzqA4uow-7mnUNKZ6Dd17vivv4vJ6B2x-Xm8V1t7q5Wi4uVp2hnNWOSuYNJohyTXsr3UCHkRrT98xQO7L2R-GJx2akg-eWES-cEwxJNnLKsHf0DHw99u5z-jm7UtUUinG7nY4uzUURPAiBZU9IQ7-8QO_TnGN7nSIMcdFT3stXqacuhtgjRY6UyamU7Lza5zDpfFAYqUeB6ihQNYHqSaDCLfT5uXoeJ2f_Rf4aawA9AqWN4p3L_-9-pfYP1OylHg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2186614049</pqid></control><display><type>article</type><title>The Haphazard Pattern in Grade-3 Endometrioid Carcinoma Is Associated with Poor Prognosis and Tumor Lymphocyte Infiltration</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>Miyamoto, Morikazu ; Takano, Masashi ; Tsuda, Hitoshi ; Matsuura, Hiroko ; Sakamoto, Takahiro ; Takasaki, Kazuki ; Kato, Kento ; Soyama, Hiroaki ; Aoyama, Tadashi ; Ishibashi, Hiroki ; Iwahashi, Hideki ; Furuya, Kenichi</creator><creatorcontrib>Miyamoto, Morikazu ; Takano, Masashi ; Tsuda, Hitoshi ; Matsuura, Hiroko ; Sakamoto, Takahiro ; Takasaki, Kazuki ; Kato, Kento ; Soyama, Hiroaki ; Aoyama, Tadashi ; Ishibashi, Hiroki ; Iwahashi, Hideki ; Furuya, Kenichi</creatorcontrib><description><![CDATA[The aim of this study was to examine the associations among the haphazard invasive patterns, defined as directionless infiltration into the myometrium; expression of key proteins; tumor infiltrative lymphocytes (TILs); and the prognosis of gade-3 endometrioid carcinoma (G3EC). Between 1990 and 2013, patients with G3EC who underwent surgery at our hospital were identified. Invasive patterns were classified into either haphazard, infiltrative, or expansile patterns. The estrogen, progesterone, androgen receptor, cytokeratin 5/6, epidermal growth factor receptor, E-cadherin, snail-2, vimentin, ZEB1, chromogranin A, synaptophysin, MLH1, MSH2, MSH6, and PMS2 levels were evaluated by immunochemical analysis. The degree of strong or weak lymphocyte infiltration (LI) were evaluated using zone formation of LI at the invasive front. Haphazard, infiltrative, and expansile patterns were discovered in 8 (18%), 6 (13%), and 31 (69%) cases, respectively. Cases with the haphazard patterns were diagnosed at a more advanced stage (
p
< 0.01) and recurred more frequently (
p
< 0.01). There were statistical differences in progression-free survival (PFS) and overall survival (OS) between the three groups (PFS;
p
< 0.01: OS;
p
< 0.01). In multivariate analysis, only the haphazard pattern was found to be an independent, worse prognostic factor of PFS (Hazard ratio (HR) =10.8,
p
< 0.01) and OS (HR = 23.3,
p
< 0.01). Furthermore, the haphazard invasive pattern was related with weak LI (
p
< 0.01) but not with the expression of all proteins analyzed. The haphazard pattern was found to be a worse prognostic factor and was associated with weak LI in G3EC. The aggressive feature of G3EC might be associated with LI but not tumor biology.]]></description><identifier>ISSN: 1219-4956</identifier><identifier>EISSN: 1532-2807</identifier><identifier>DOI: 10.1007/s12253-019-00624-1</identifier><identifier>PMID: 30810895</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Aged ; Androgen receptors ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoma, Endometrioid - immunology ; Carcinoma, Endometrioid - pathology ; Cytokeratin ; E-cadherin ; Endometrial cancer ; Endometrial Neoplasms - immunology ; Endometrial Neoplasms - pathology ; Epidermal growth factor ; Female ; Humans ; Immunology ; Infiltration ; Invasiveness ; Lymphocytes ; Lymphocytes, Tumor-Infiltrating - pathology ; Medical prognosis ; Metastases ; Middle Aged ; MLH1 protein ; MSH2 protein ; MSH6 protein ; Multivariate analysis ; Myometrium ; Neoplasm Grading ; Oncology ; Original Article ; Pathology ; Progesterone ; Prognosis ; Progression-Free Survival ; Proteins ; Surgery ; Synaptophysin ; Vimentin</subject><ispartof>Pathology oncology research, 2020-04, Vol.26 (2), p.783-790</ispartof><rights>Arányi Lajos Foundation 2019</rights><rights>Pathology & Oncology Research is a copyright of Springer, (2019). All Rights Reserved.</rights><rights>Arányi Lajos Foundation 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c354t-394fc12035a37d9e838b3cc774c3db42196f2f1cb38f5d42f6ee64094b5341fe3</cites><orcidid>0000-0003-4763-0926</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12253-019-00624-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12253-019-00624-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30810895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyamoto, Morikazu</creatorcontrib><creatorcontrib>Takano, Masashi</creatorcontrib><creatorcontrib>Tsuda, Hitoshi</creatorcontrib><creatorcontrib>Matsuura, Hiroko</creatorcontrib><creatorcontrib>Sakamoto, Takahiro</creatorcontrib><creatorcontrib>Takasaki, Kazuki</creatorcontrib><creatorcontrib>Kato, Kento</creatorcontrib><creatorcontrib>Soyama, Hiroaki</creatorcontrib><creatorcontrib>Aoyama, Tadashi</creatorcontrib><creatorcontrib>Ishibashi, Hiroki</creatorcontrib><creatorcontrib>Iwahashi, Hideki</creatorcontrib><creatorcontrib>Furuya, Kenichi</creatorcontrib><title>The Haphazard Pattern in Grade-3 Endometrioid Carcinoma Is Associated with Poor Prognosis and Tumor Lymphocyte Infiltration</title><title>Pathology oncology research</title><addtitle>Pathol. Oncol. Res</addtitle><addtitle>Pathol Oncol Res</addtitle><description><![CDATA[The aim of this study was to examine the associations among the haphazard invasive patterns, defined as directionless infiltration into the myometrium; expression of key proteins; tumor infiltrative lymphocytes (TILs); and the prognosis of gade-3 endometrioid carcinoma (G3EC). Between 1990 and 2013, patients with G3EC who underwent surgery at our hospital were identified. Invasive patterns were classified into either haphazard, infiltrative, or expansile patterns. The estrogen, progesterone, androgen receptor, cytokeratin 5/6, epidermal growth factor receptor, E-cadherin, snail-2, vimentin, ZEB1, chromogranin A, synaptophysin, MLH1, MSH2, MSH6, and PMS2 levels were evaluated by immunochemical analysis. The degree of strong or weak lymphocyte infiltration (LI) were evaluated using zone formation of LI at the invasive front. Haphazard, infiltrative, and expansile patterns were discovered in 8 (18%), 6 (13%), and 31 (69%) cases, respectively. Cases with the haphazard patterns were diagnosed at a more advanced stage (
p
< 0.01) and recurred more frequently (
p
< 0.01). There were statistical differences in progression-free survival (PFS) and overall survival (OS) between the three groups (PFS;
p
< 0.01: OS;
p
< 0.01). In multivariate analysis, only the haphazard pattern was found to be an independent, worse prognostic factor of PFS (Hazard ratio (HR) =10.8,
p
< 0.01) and OS (HR = 23.3,
p
< 0.01). Furthermore, the haphazard invasive pattern was related with weak LI (
p
< 0.01) but not with the expression of all proteins analyzed. The haphazard pattern was found to be a worse prognostic factor and was associated with weak LI in G3EC. The aggressive feature of G3EC might be associated with LI but not tumor biology.]]></description><subject>Adult</subject><subject>Aged</subject><subject>Androgen receptors</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma, Endometrioid - immunology</subject><subject>Carcinoma, Endometrioid - pathology</subject><subject>Cytokeratin</subject><subject>E-cadherin</subject><subject>Endometrial cancer</subject><subject>Endometrial Neoplasms - immunology</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Epidermal growth factor</subject><subject>Female</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infiltration</subject><subject>Invasiveness</subject><subject>Lymphocytes</subject><subject>Lymphocytes, Tumor-Infiltrating - pathology</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>MLH1 protein</subject><subject>MSH2 protein</subject><subject>MSH6 protein</subject><subject>Multivariate analysis</subject><subject>Myometrium</subject><subject>Neoplasm Grading</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Progesterone</subject><subject>Prognosis</subject><subject>Progression-Free Survival</subject><subject>Proteins</subject><subject>Surgery</subject><subject>Synaptophysin</subject><subject>Vimentin</subject><issn>1219-4956</issn><issn>1532-2807</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1rHCEch6W0NGnSL9BDEXrpZVrfZzyGJU0WFrKHzVkcX7KGHd2qQ9n0y9dk0xZyyEnx__x-Kg8AnzD6hhHqvxdMCKcdwrJDSBDW4TfgFHNKOjKg_m3bkzZikosT8KGUe9RCQor34ISiAaNB8lPwe7N18Frvt_pBZwvXulaXIwwRXmVtXUfhZbRpcjWHFCxc6GxCTJOGywIvSkkm6Oos_BXqFq5TynCd011MJRSoo4WbeWpnq8O03yZzqA4uow-7mnUNKZ6Dd17vivv4vJ6B2x-Xm8V1t7q5Wi4uVp2hnNWOSuYNJohyTXsr3UCHkRrT98xQO7L2R-GJx2akg-eWES-cEwxJNnLKsHf0DHw99u5z-jm7UtUUinG7nY4uzUURPAiBZU9IQ7-8QO_TnGN7nSIMcdFT3stXqacuhtgjRY6UyamU7Lza5zDpfFAYqUeB6ihQNYHqSaDCLfT5uXoeJ2f_Rf4aawA9AqWN4p3L_-9-pfYP1OylHg</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Miyamoto, Morikazu</creator><creator>Takano, Masashi</creator><creator>Tsuda, Hitoshi</creator><creator>Matsuura, Hiroko</creator><creator>Sakamoto, Takahiro</creator><creator>Takasaki, Kazuki</creator><creator>Kato, Kento</creator><creator>Soyama, Hiroaki</creator><creator>Aoyama, Tadashi</creator><creator>Ishibashi, Hiroki</creator><creator>Iwahashi, Hideki</creator><creator>Furuya, Kenichi</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4763-0926</orcidid></search><sort><creationdate>20200401</creationdate><title>The Haphazard Pattern in Grade-3 Endometrioid Carcinoma Is Associated with Poor Prognosis and Tumor Lymphocyte Infiltration</title><author>Miyamoto, Morikazu ; Takano, Masashi ; Tsuda, Hitoshi ; Matsuura, Hiroko ; Sakamoto, Takahiro ; Takasaki, Kazuki ; Kato, Kento ; Soyama, Hiroaki ; Aoyama, Tadashi ; Ishibashi, Hiroki ; Iwahashi, Hideki ; Furuya, Kenichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-394fc12035a37d9e838b3cc774c3db42196f2f1cb38f5d42f6ee64094b5341fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Androgen receptors</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma, Endometrioid - immunology</topic><topic>Carcinoma, Endometrioid - pathology</topic><topic>Cytokeratin</topic><topic>E-cadherin</topic><topic>Endometrial cancer</topic><topic>Endometrial Neoplasms - immunology</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Epidermal growth factor</topic><topic>Female</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infiltration</topic><topic>Invasiveness</topic><topic>Lymphocytes</topic><topic>Lymphocytes, Tumor-Infiltrating - pathology</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>MLH1 protein</topic><topic>MSH2 protein</topic><topic>MSH6 protein</topic><topic>Multivariate analysis</topic><topic>Myometrium</topic><topic>Neoplasm Grading</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pathology</topic><topic>Progesterone</topic><topic>Prognosis</topic><topic>Progression-Free Survival</topic><topic>Proteins</topic><topic>Surgery</topic><topic>Synaptophysin</topic><topic>Vimentin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyamoto, Morikazu</creatorcontrib><creatorcontrib>Takano, Masashi</creatorcontrib><creatorcontrib>Tsuda, Hitoshi</creatorcontrib><creatorcontrib>Matsuura, Hiroko</creatorcontrib><creatorcontrib>Sakamoto, Takahiro</creatorcontrib><creatorcontrib>Takasaki, Kazuki</creatorcontrib><creatorcontrib>Kato, Kento</creatorcontrib><creatorcontrib>Soyama, Hiroaki</creatorcontrib><creatorcontrib>Aoyama, Tadashi</creatorcontrib><creatorcontrib>Ishibashi, Hiroki</creatorcontrib><creatorcontrib>Iwahashi, Hideki</creatorcontrib><creatorcontrib>Furuya, Kenichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology oncology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyamoto, Morikazu</au><au>Takano, Masashi</au><au>Tsuda, Hitoshi</au><au>Matsuura, Hiroko</au><au>Sakamoto, Takahiro</au><au>Takasaki, Kazuki</au><au>Kato, Kento</au><au>Soyama, Hiroaki</au><au>Aoyama, Tadashi</au><au>Ishibashi, Hiroki</au><au>Iwahashi, Hideki</au><au>Furuya, Kenichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Haphazard Pattern in Grade-3 Endometrioid Carcinoma Is Associated with Poor Prognosis and Tumor Lymphocyte Infiltration</atitle><jtitle>Pathology oncology research</jtitle><stitle>Pathol. Oncol. Res</stitle><addtitle>Pathol Oncol Res</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>26</volume><issue>2</issue><spage>783</spage><epage>790</epage><pages>783-790</pages><issn>1219-4956</issn><eissn>1532-2807</eissn><abstract><![CDATA[The aim of this study was to examine the associations among the haphazard invasive patterns, defined as directionless infiltration into the myometrium; expression of key proteins; tumor infiltrative lymphocytes (TILs); and the prognosis of gade-3 endometrioid carcinoma (G3EC). Between 1990 and 2013, patients with G3EC who underwent surgery at our hospital were identified. Invasive patterns were classified into either haphazard, infiltrative, or expansile patterns. The estrogen, progesterone, androgen receptor, cytokeratin 5/6, epidermal growth factor receptor, E-cadherin, snail-2, vimentin, ZEB1, chromogranin A, synaptophysin, MLH1, MSH2, MSH6, and PMS2 levels were evaluated by immunochemical analysis. The degree of strong or weak lymphocyte infiltration (LI) were evaluated using zone formation of LI at the invasive front. Haphazard, infiltrative, and expansile patterns were discovered in 8 (18%), 6 (13%), and 31 (69%) cases, respectively. Cases with the haphazard patterns were diagnosed at a more advanced stage (
p
< 0.01) and recurred more frequently (
p
< 0.01). There were statistical differences in progression-free survival (PFS) and overall survival (OS) between the three groups (PFS;
p
< 0.01: OS;
p
< 0.01). In multivariate analysis, only the haphazard pattern was found to be an independent, worse prognostic factor of PFS (Hazard ratio (HR) =10.8,
p
< 0.01) and OS (HR = 23.3,
p
< 0.01). Furthermore, the haphazard invasive pattern was related with weak LI (
p
< 0.01) but not with the expression of all proteins analyzed. The haphazard pattern was found to be a worse prognostic factor and was associated with weak LI in G3EC. The aggressive feature of G3EC might be associated with LI but not tumor biology.]]></abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>30810895</pmid><doi>10.1007/s12253-019-00624-1</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4763-0926</orcidid></addata></record> |
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| subjects | Adult Aged Androgen receptors Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Endometrioid - immunology Carcinoma, Endometrioid - pathology Cytokeratin E-cadherin Endometrial cancer Endometrial Neoplasms - immunology Endometrial Neoplasms - pathology Epidermal growth factor Female Humans Immunology Infiltration Invasiveness Lymphocytes Lymphocytes, Tumor-Infiltrating - pathology Medical prognosis Metastases Middle Aged MLH1 protein MSH2 protein MSH6 protein Multivariate analysis Myometrium Neoplasm Grading Oncology Original Article Pathology Progesterone Prognosis Progression-Free Survival Proteins Surgery Synaptophysin Vimentin |
| title | The Haphazard Pattern in Grade-3 Endometrioid Carcinoma Is Associated with Poor Prognosis and Tumor Lymphocyte Infiltration |
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