Endoscopic Management of Vesicoureteral Reflux and Long-term Follow-up
Objectives To report our experience with endoscopic management of vesicoureteral reflux (VUR) by injection of a tissue bulking substance–Dextranomer/ hyaluronic acid copolymer at vesicoureteric junction. Design Retrospective analyses of case records. Setting Pediatric Surgery department in a tertiar...
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| Veröffentlicht in: | Indian pediatrics 2018-12, Vol.55 (12), p.1046-1049 |
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| creator | Rao, Kln Menon, Prema Samujh, R Mahajan, Jk Bawa, M Malik, Ma Mittal, Br |
| description | Objectives
To report our experience with endoscopic management of vesicoureteral reflux (VUR) by injection of a tissue bulking substance–Dextranomer/ hyaluronic acid copolymer at vesicoureteric junction.
Design
Retrospective analyses of case records.
Setting
Pediatric Surgery department in a tertiary care government Institute.
Participants
500 children (767 renal units) consecutively referred to the out-patient department with vesicoureteral reflux noted on micturating cysto-urethrogram (MCU) over a period of 13 years (2004-2016).
Intervention
Preoperative VUR grading and renal scars on radionuclide scans were documented. Dextranomer hyaluronic acid copolymer was injected through a cystoscope at the vesicoureteral junction as a day care procedure under short anesthesia. Patients were followed (average duration 27.3 mo) with clinical assessment, periodic urine cultures and renal scans.
Main outcome measure
Cessation of VUR and symptomatic relief / clinical success postoperatively at 3 months.
Results
Complete symptomatic relief was obtained in 482 (96.4%) patients. In 681 units where MCU was available, 614 (90%) units showed resolution of VUR.
Conclusion
Endoscopic injection of tissue bulking substances at vesicoureteric junction to stop VUR seems to be an effective intervention |
| doi_str_mv | 10.1007/s13312-018-1439-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2186619333</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2186619333</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-f58bc60b7614c9ee2414a45a6bfdbc3e7b2f4ea7ff075c9373880ab70d4930ac3</originalsourceid><addsrcrecordid>eNp9kEFLxDAQhYMo7rr6A7xIj16iSZM07VGWXRVWBFGvIU0nS5e2qUmL-u_N0tWjc5lh5r0H8yF0SckNJUTeBsoYTTGhOaacFVgcoTkpJMdSiOI4zoQWOCMZnaGzEHaEpCwV9BTNGJFccCnmaL3qKheM62uTPOlOb6GFbkicTd4h1MaNHgbwuklewDbjV6K7Ktm4bovjtk3WrmncJx77c3RidRPg4tAX6G29el0-4M3z_ePyboMN43zAVuSlyUgpM8pNAZByyjUXOittVRoGskwtBy2tJVKYgkmW50SXklS8YEQbtkDXU27v3ccIYVBtHQw0je7AjUGlNM8yWrBYC0QnqfEuBA9W9b5utf9WlKg9PjXhUxGf2uNTInquDvFj2UL15_jlFQXpJAjx1G3Bq11E1MWX_0n9AUjDeow</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2186619333</pqid></control><display><type>article</type><title>Endoscopic Management of Vesicoureteral Reflux and Long-term Follow-up</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>Rao, Kln ; Menon, Prema ; Samujh, R ; Mahajan, Jk ; Bawa, M ; Malik, Ma ; Mittal, Br</creator><creatorcontrib>Rao, Kln ; Menon, Prema ; Samujh, R ; Mahajan, Jk ; Bawa, M ; Malik, Ma ; Mittal, Br</creatorcontrib><description>Objectives
To report our experience with endoscopic management of vesicoureteral reflux (VUR) by injection of a tissue bulking substance–Dextranomer/ hyaluronic acid copolymer at vesicoureteric junction.
Design
Retrospective analyses of case records.
Setting
Pediatric Surgery department in a tertiary care government Institute.
Participants
500 children (767 renal units) consecutively referred to the out-patient department with vesicoureteral reflux noted on micturating cysto-urethrogram (MCU) over a period of 13 years (2004-2016).
Intervention
Preoperative VUR grading and renal scars on radionuclide scans were documented. Dextranomer hyaluronic acid copolymer was injected through a cystoscope at the vesicoureteral junction as a day care procedure under short anesthesia. Patients were followed (average duration 27.3 mo) with clinical assessment, periodic urine cultures and renal scans.
Main outcome measure
Cessation of VUR and symptomatic relief / clinical success postoperatively at 3 months.
Results
Complete symptomatic relief was obtained in 482 (96.4%) patients. In 681 units where MCU was available, 614 (90%) units showed resolution of VUR.
Conclusion
Endoscopic injection of tissue bulking substances at vesicoureteric junction to stop VUR seems to be an effective intervention</description><identifier>ISSN: 0019-6061</identifier><identifier>EISSN: 0974-7559</identifier><identifier>DOI: 10.1007/s13312-018-1439-5</identifier><identifier>PMID: 30745475</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Adolescent ; Child ; Child, Preschool ; Dextrans - administration & dosage ; Dextrans - therapeutic use ; Endoscopy ; Female ; Follow-Up Studies ; Humans ; Hyaluronic Acid - administration & dosage ; Hyaluronic Acid - therapeutic use ; Infant ; Injections ; Male ; Maternal and Child Health ; Medicine ; Medicine & Public Health ; Pediatric Surgery ; Pediatrics ; Research Paper ; Retrospective Studies ; Treatment Outcome ; Urological Agents - administration & dosage ; Urological Agents - therapeutic use ; Vesico-Ureteral Reflux - diagnostic imaging ; Vesico-Ureteral Reflux - therapy</subject><ispartof>Indian pediatrics, 2018-12, Vol.55 (12), p.1046-1049</ispartof><rights>Indian Academy of Pediatrics 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-f58bc60b7614c9ee2414a45a6bfdbc3e7b2f4ea7ff075c9373880ab70d4930ac3</citedby><cites>FETCH-LOGICAL-c344t-f58bc60b7614c9ee2414a45a6bfdbc3e7b2f4ea7ff075c9373880ab70d4930ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13312-018-1439-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13312-018-1439-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30745475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rao, Kln</creatorcontrib><creatorcontrib>Menon, Prema</creatorcontrib><creatorcontrib>Samujh, R</creatorcontrib><creatorcontrib>Mahajan, Jk</creatorcontrib><creatorcontrib>Bawa, M</creatorcontrib><creatorcontrib>Malik, Ma</creatorcontrib><creatorcontrib>Mittal, Br</creatorcontrib><title>Endoscopic Management of Vesicoureteral Reflux and Long-term Follow-up</title><title>Indian pediatrics</title><addtitle>Indian Pediatr</addtitle><addtitle>Indian Pediatr</addtitle><description>Objectives
To report our experience with endoscopic management of vesicoureteral reflux (VUR) by injection of a tissue bulking substance–Dextranomer/ hyaluronic acid copolymer at vesicoureteric junction.
Design
Retrospective analyses of case records.
Setting
Pediatric Surgery department in a tertiary care government Institute.
Participants
500 children (767 renal units) consecutively referred to the out-patient department with vesicoureteral reflux noted on micturating cysto-urethrogram (MCU) over a period of 13 years (2004-2016).
Intervention
Preoperative VUR grading and renal scars on radionuclide scans were documented. Dextranomer hyaluronic acid copolymer was injected through a cystoscope at the vesicoureteral junction as a day care procedure under short anesthesia. Patients were followed (average duration 27.3 mo) with clinical assessment, periodic urine cultures and renal scans.
Main outcome measure
Cessation of VUR and symptomatic relief / clinical success postoperatively at 3 months.
Results
Complete symptomatic relief was obtained in 482 (96.4%) patients. In 681 units where MCU was available, 614 (90%) units showed resolution of VUR.
Conclusion
Endoscopic injection of tissue bulking substances at vesicoureteric junction to stop VUR seems to be an effective intervention</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dextrans - administration & dosage</subject><subject>Dextrans - therapeutic use</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hyaluronic Acid - administration & dosage</subject><subject>Hyaluronic Acid - therapeutic use</subject><subject>Infant</subject><subject>Injections</subject><subject>Male</subject><subject>Maternal and Child Health</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Research Paper</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><subject>Urological Agents - administration & dosage</subject><subject>Urological Agents - therapeutic use</subject><subject>Vesico-Ureteral Reflux - diagnostic imaging</subject><subject>Vesico-Ureteral Reflux - therapy</subject><issn>0019-6061</issn><issn>0974-7559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLxDAQhYMo7rr6A7xIj16iSZM07VGWXRVWBFGvIU0nS5e2qUmL-u_N0tWjc5lh5r0H8yF0SckNJUTeBsoYTTGhOaacFVgcoTkpJMdSiOI4zoQWOCMZnaGzEHaEpCwV9BTNGJFccCnmaL3qKheM62uTPOlOb6GFbkicTd4h1MaNHgbwuklewDbjV6K7Ktm4bovjtk3WrmncJx77c3RidRPg4tAX6G29el0-4M3z_ePyboMN43zAVuSlyUgpM8pNAZByyjUXOittVRoGskwtBy2tJVKYgkmW50SXklS8YEQbtkDXU27v3ccIYVBtHQw0je7AjUGlNM8yWrBYC0QnqfEuBA9W9b5utf9WlKg9PjXhUxGf2uNTInquDvFj2UL15_jlFQXpJAjx1G3Bq11E1MWX_0n9AUjDeow</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Rao, Kln</creator><creator>Menon, Prema</creator><creator>Samujh, R</creator><creator>Mahajan, Jk</creator><creator>Bawa, M</creator><creator>Malik, Ma</creator><creator>Mittal, Br</creator><general>Springer India</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20181201</creationdate><title>Endoscopic Management of Vesicoureteral Reflux and Long-term Follow-up</title><author>Rao, Kln ; Menon, Prema ; Samujh, R ; Mahajan, Jk ; Bawa, M ; Malik, Ma ; Mittal, Br</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-f58bc60b7614c9ee2414a45a6bfdbc3e7b2f4ea7ff075c9373880ab70d4930ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dextrans - administration & dosage</topic><topic>Dextrans - therapeutic use</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hyaluronic Acid - administration & dosage</topic><topic>Hyaluronic Acid - therapeutic use</topic><topic>Infant</topic><topic>Injections</topic><topic>Male</topic><topic>Maternal and Child Health</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Research Paper</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><topic>Urological Agents - administration & dosage</topic><topic>Urological Agents - therapeutic use</topic><topic>Vesico-Ureteral Reflux - diagnostic imaging</topic><topic>Vesico-Ureteral Reflux - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rao, Kln</creatorcontrib><creatorcontrib>Menon, Prema</creatorcontrib><creatorcontrib>Samujh, R</creatorcontrib><creatorcontrib>Mahajan, Jk</creatorcontrib><creatorcontrib>Bawa, M</creatorcontrib><creatorcontrib>Malik, Ma</creatorcontrib><creatorcontrib>Mittal, Br</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rao, Kln</au><au>Menon, Prema</au><au>Samujh, R</au><au>Mahajan, Jk</au><au>Bawa, M</au><au>Malik, Ma</au><au>Mittal, Br</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endoscopic Management of Vesicoureteral Reflux and Long-term Follow-up</atitle><jtitle>Indian pediatrics</jtitle><stitle>Indian Pediatr</stitle><addtitle>Indian Pediatr</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>55</volume><issue>12</issue><spage>1046</spage><epage>1049</epage><pages>1046-1049</pages><issn>0019-6061</issn><eissn>0974-7559</eissn><abstract>Objectives
To report our experience with endoscopic management of vesicoureteral reflux (VUR) by injection of a tissue bulking substance–Dextranomer/ hyaluronic acid copolymer at vesicoureteric junction.
Design
Retrospective analyses of case records.
Setting
Pediatric Surgery department in a tertiary care government Institute.
Participants
500 children (767 renal units) consecutively referred to the out-patient department with vesicoureteral reflux noted on micturating cysto-urethrogram (MCU) over a period of 13 years (2004-2016).
Intervention
Preoperative VUR grading and renal scars on radionuclide scans were documented. Dextranomer hyaluronic acid copolymer was injected through a cystoscope at the vesicoureteral junction as a day care procedure under short anesthesia. Patients were followed (average duration 27.3 mo) with clinical assessment, periodic urine cultures and renal scans.
Main outcome measure
Cessation of VUR and symptomatic relief / clinical success postoperatively at 3 months.
Results
Complete symptomatic relief was obtained in 482 (96.4%) patients. In 681 units where MCU was available, 614 (90%) units showed resolution of VUR.
Conclusion
Endoscopic injection of tissue bulking substances at vesicoureteric junction to stop VUR seems to be an effective intervention</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>30745475</pmid><doi>10.1007/s13312-018-1439-5</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Child Child, Preschool Dextrans - administration & dosage Dextrans - therapeutic use Endoscopy Female Follow-Up Studies Humans Hyaluronic Acid - administration & dosage Hyaluronic Acid - therapeutic use Infant Injections Male Maternal and Child Health Medicine Medicine & Public Health Pediatric Surgery Pediatrics Research Paper Retrospective Studies Treatment Outcome Urological Agents - administration & dosage Urological Agents - therapeutic use Vesico-Ureteral Reflux - diagnostic imaging Vesico-Ureteral Reflux - therapy |
| title | Endoscopic Management of Vesicoureteral Reflux and Long-term Follow-up |
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