Access to Multisubstituted 2(5H)‑Furanones Using Hydrogen Bonding-Promoted Ring-Closing Metathesis and Polyamine Workup

Structurally complex 2­(5H)-furanones are potentially challenging targets for ring-closing metathesis (RCM). A hydrogen bonding-guided RCM strategy was developed in this study to provide 3-substituted and 3,4-disubstituted 2­(5H)-furanones in moderate to high yields with broad functional group tolerance. A workup procedure using ethylenediamine-derived polyamines such as tetraethylenepentylamine was also established to effectively remove Ru residues in products.