Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors

PIM kinase family (PIM-1, PIM-2 and PIM-3) is an appealing target for the discovery and development of selective inhibitors, useful in various disease conditions in which these proteins are highly expressed, such as cancer. The significant effort put, in the recent years, towards the development of...

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Veröffentlicht in:	European journal of medicinal chemistry 2019-04, Vol.168, p.87-109
Hauptverfasser:	Martínez-González, Sonia, Rodríguez-Arístegui, Sonsoles, Gómez de la Oliva, Cristina Ana, Hernández, Ana Isabel, González Cantalapiedra, Esther, Varela, Carmen, García, Ana Belén, Rabal, Obdulia, Oyarzabal, Julen, Bischoff, James R., Klett, Javier, Albarrán, María Isabel, Cebriá, Antonio, Ajenjo, Nuria, García-Serelde, Beatriz, Gómez-Casero, Elena, Cuadrado-Urbano, Manuel, Cebrián, David, Blanco-Aparicio, Carmen, Pastor, Joaquín
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer agents Antiproliferative activity Chemical probes pan-PIM inhibitors PIM-1 inhibitors Selective PIM-1/PIM-3 inhibitors Synergistic effects
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