Treatment with myo-inositol attenuates binding of the carbohydrate-responsive element-binding protein to the ChREBP-β and FASN genes in rat nonalcoholic fatty liver induced by high-fructose diet

Dietary supplementation with the major lipotrope myo-inositol (MI) potently reduces triglyceride (TG) content and expression levels of the fatty acid synthesis genes, for example, fatty acid synthase (FASN), in rat nonalcoholic fatty liver induced by high-fructose diet. Fatty acid synthesis genes ar...

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Veröffentlicht in:	Nutrition research (New York, N.Y.) N.Y.), 2019-04, Vol.64, p.49-55
Hauptverfasser:	Shimada, Masaya, Ichigo, Yutaro, Shirouchi, Bungo, Takashima, Shigeo, Inagaki, Mizuho, Nakagawa, Tomoyuki, Hayakawa, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA Carboxylase - metabolism Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Carbohydrate-responsive element-binding protein Diet - adverse effects Dietary Sugars - administration & dosage Dietary Sugars - adverse effects Dietary Sugars - metabolism Dietary Supplements Fatty acid synthase Fatty Acid Synthase, Type I - genetics Fatty Acid Synthase, Type I - metabolism Fructose Fructose - administration & dosage Fructose - adverse effects Fructose - metabolism Gene Expression Glucosephosphate Dehydrogenase - metabolism Inositol - pharmacology Inositol - therapeutic use Lipogenesis - drug effects Lipotropic Agents - pharmacology Lipotropic Agents - therapeutic use Liver - drug effects Liver - metabolism Malate Dehydrogenase - metabolism Male myo-Inositol Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Nonalcoholic fatty liver Nuclear Proteins - metabolism Rats, Wistar Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism Transcription Factors - metabolism Triglyceride Triglycerides - metabolism
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