Model-assisted Design of Experiments as a concept for knowledge-based bioprocess development

Design of Experiments methods offer systematic tools for bioprocess development in Quality by Design, but their major drawback is the user-defined choice of factor boundary values. This can lead to several iterative rounds of time-consuming and costly experiments. In this study, a model-assisted Des...

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Veröffentlicht in:	Bioprocess and biosystems engineering 2019-05, Vol.42 (5), p.867-882
Hauptverfasser:	Möller, Johannes, Kuchemüller, Kim B., Steinmetz, Tobias, Koopmann, Kirsten S., Pörtner, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Batch culture Biotechnology Chemistry Chemistry and Materials Science Combinations (mathematics) Computer simulation Design Design of experiments Environmental Engineering/Biotechnology Food Science Industrial and Production Engineering Industrial Chemistry/Chemical Engineering Iterative methods Knowledge bases (artificial intelligence) Optimization Process parameters Research Paper
Online-Zugang:	Volltext
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