Health factors and spinal cord injury: a prospective study of risk of cause-specific mortality
Study design Prospective cohort study. Objectives: Identify the risk and protective factors of all-cause and cause-specific mortality among persons with traumatic spinal cord injury (SCI). Setting Rehabilitation specialty hospital in the Southeastern United States. Methods A prospective cohort study...
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| Veröffentlicht in: | Spinal cord 2019-07, Vol.57 (7), p.594-602 |
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| creator | Cao, Yue DiPiro, Nicole Krause, James S. |
| description | Study design
Prospective cohort study.
Objectives:
Identify the risk and protective factors of all-cause and cause-specific mortality among persons with traumatic spinal cord injury (SCI).
Setting
Rehabilitation specialty hospital in the Southeastern United States.
Methods
A prospective cohort study was conducted with 3070 adults with traumatic SCI who were a minimum of 1 year post-injury at assessment. Prospective data were collected in 1997–1998 and 2007–2010, with mortality determined as of 31 December, 2016. The deceased were classified into six categories based on underlying cause of death: septicemia, pneumonia and influenza, cancer, heart and blood vessel diseases, unintentional injuries, and all other causes. The competing risk analysis strategy applied to each of the specific causes.
Results
There were a total of 803 observed deaths among the 2979 final study sample. After controlling for demographic and injury characteristics, general health, pressure ulcer history, and symptoms of infections were significantly associated with all-cause mortality. Except for cancer, they were also related with at least one of the specific causes of death, whereas orthopedic complications and subsequent injuries were unrelated to any cause.
Conclusions
Three health domains, global health, pressure ulcers, and symptoms of illness or infection, were significantly associated with mortality after SCI, and the patterns of association varied as a function of specific cause of death. |
| doi_str_mv | 10.1038/s41393-019-0264-6 |
| format | Article |
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Prospective cohort study.
Objectives:
Identify the risk and protective factors of all-cause and cause-specific mortality among persons with traumatic spinal cord injury (SCI).
Setting
Rehabilitation specialty hospital in the Southeastern United States.
Methods
A prospective cohort study was conducted with 3070 adults with traumatic SCI who were a minimum of 1 year post-injury at assessment. Prospective data were collected in 1997–1998 and 2007–2010, with mortality determined as of 31 December, 2016. The deceased were classified into six categories based on underlying cause of death: septicemia, pneumonia and influenza, cancer, heart and blood vessel diseases, unintentional injuries, and all other causes. The competing risk analysis strategy applied to each of the specific causes.
Results
There were a total of 803 observed deaths among the 2979 final study sample. After controlling for demographic and injury characteristics, general health, pressure ulcer history, and symptoms of infections were significantly associated with all-cause mortality. Except for cancer, they were also related with at least one of the specific causes of death, whereas orthopedic complications and subsequent injuries were unrelated to any cause.
Conclusions
Three health domains, global health, pressure ulcers, and symptoms of illness or infection, were significantly associated with mortality after SCI, and the patterns of association varied as a function of specific cause of death.</description><identifier>ISSN: 1362-4393</identifier><identifier>EISSN: 1476-5624</identifier><identifier>DOI: 10.1038/s41393-019-0264-6</identifier><identifier>PMID: 30804424</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/1807 ; 692/499 ; Adult ; Anatomy ; Biomedical and Life Sciences ; Biomedicine ; Blood vessels ; Cancer ; Cohort Studies ; Complications ; Coronary artery disease ; Death ; Demographics ; Domains ; Female ; Global health ; Health risk assessment ; Health risks ; Health Status ; Heart ; Heart diseases ; Human Physiology ; Humans ; Infections ; Infections - complications ; Infections - mortality ; Influenza ; Injuries ; Injury analysis ; Male ; Middle Aged ; Mortality ; Neurochemistry ; Neuropsychology ; Neurosciences ; Pressure ; Pressure Ulcer - complications ; Pressure Ulcer - mortality ; Prospective Studies ; Rehabilitation ; Risk analysis ; Risk Factors ; Septicemia ; Signs and symptoms ; Spinal cord injuries ; Spinal Cord Injuries - complications ; Spinal Cord Injuries - mortality ; Ulcers</subject><ispartof>Spinal cord, 2019-07, Vol.57 (7), p.594-602</ispartof><rights>International Spinal Cord Society 2019</rights><rights>2019© International Spinal Cord Society 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-3723bd5bd3b2f1723a7946cf87ac73a7dd81fa41d11762d9b0ada52f20cf1c363</citedby><cites>FETCH-LOGICAL-c415t-3723bd5bd3b2f1723a7946cf87ac73a7dd81fa41d11762d9b0ada52f20cf1c363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41393-019-0264-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41393-019-0264-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30804424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Yue</creatorcontrib><creatorcontrib>DiPiro, Nicole</creatorcontrib><creatorcontrib>Krause, James S.</creatorcontrib><title>Health factors and spinal cord injury: a prospective study of risk of cause-specific mortality</title><title>Spinal cord</title><addtitle>Spinal Cord</addtitle><addtitle>Spinal Cord</addtitle><description>Study design
Prospective cohort study.
Objectives:
Identify the risk and protective factors of all-cause and cause-specific mortality among persons with traumatic spinal cord injury (SCI).
Setting
Rehabilitation specialty hospital in the Southeastern United States.
Methods
A prospective cohort study was conducted with 3070 adults with traumatic SCI who were a minimum of 1 year post-injury at assessment. Prospective data were collected in 1997–1998 and 2007–2010, with mortality determined as of 31 December, 2016. The deceased were classified into six categories based on underlying cause of death: septicemia, pneumonia and influenza, cancer, heart and blood vessel diseases, unintentional injuries, and all other causes. The competing risk analysis strategy applied to each of the specific causes.
Results
There were a total of 803 observed deaths among the 2979 final study sample. After controlling for demographic and injury characteristics, general health, pressure ulcer history, and symptoms of infections were significantly associated with all-cause mortality. Except for cancer, they were also related with at least one of the specific causes of death, whereas orthopedic complications and subsequent injuries were unrelated to any cause.
Conclusions
Three health domains, global health, pressure ulcers, and symptoms of illness or infection, were significantly associated with mortality after SCI, and the patterns of association varied as a function of specific cause of death.</description><subject>692/1807</subject><subject>692/499</subject><subject>Adult</subject><subject>Anatomy</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood vessels</subject><subject>Cancer</subject><subject>Cohort Studies</subject><subject>Complications</subject><subject>Coronary artery disease</subject><subject>Death</subject><subject>Demographics</subject><subject>Domains</subject><subject>Female</subject><subject>Global health</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Health Status</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Infections</subject><subject>Infections - complications</subject><subject>Infections - mortality</subject><subject>Influenza</subject><subject>Injuries</subject><subject>Injury analysis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neurochemistry</subject><subject>Neuropsychology</subject><subject>Neurosciences</subject><subject>Pressure</subject><subject>Pressure Ulcer - complications</subject><subject>Pressure Ulcer - mortality</subject><subject>Prospective Studies</subject><subject>Rehabilitation</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Septicemia</subject><subject>Signs and symptoms</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - complications</subject><subject>Spinal Cord Injuries - mortality</subject><subject>Ulcers</subject><issn>1362-4393</issn><issn>1476-5624</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1r3DAQhkVpaDZpf0AvQdBLLko0kixbvZWQL1jIJb1WyPpotfHaG8kO-N9XZjcpFHKaGeaZd2ZehL4CvQDKm8ssgCtOKChCmRREfkArELUklWTiY8m5ZEQU5Bid5LyhlCpQzSd0zGlDhWBihX7dedONf3AwdhxSxqZ3OO9ibzpsh-Rw7DdTmr9jg3dpyDtvx_jicR4nN-Mh4BTz0xKtmbInSz-GaPF2SKPp4jh_RkfBdNl_OcRT9PPm-vHqjqwfbu-vfqyJFVCNhNeMt65qHW9ZgFKYWglpQ1MbW5fCuQaCEeAAasmcaqlxpmKBURvAcslP0flet1z5PPk86m3M1ned6f0wZc2gkSBko6Cg3_5DN8OUysOFYhWTUikuCgV7ypa3c_JB71LcmjRroHoxX-_N18V8vZivlyPODspTu_XubeLV7QKwPZBLq__t07_V76v-BSqWj0k</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Cao, Yue</creator><creator>DiPiro, Nicole</creator><creator>Krause, James S.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190701</creationdate><title>Health factors and spinal cord injury: a prospective study of risk of cause-specific mortality</title><author>Cao, Yue ; DiPiro, Nicole ; Krause, James S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-3723bd5bd3b2f1723a7946cf87ac73a7dd81fa41d11762d9b0ada52f20cf1c363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>692/1807</topic><topic>692/499</topic><topic>Adult</topic><topic>Anatomy</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood vessels</topic><topic>Cancer</topic><topic>Cohort Studies</topic><topic>Complications</topic><topic>Coronary artery disease</topic><topic>Death</topic><topic>Demographics</topic><topic>Domains</topic><topic>Female</topic><topic>Global health</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Health Status</topic><topic>Heart</topic><topic>Heart diseases</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Infections</topic><topic>Infections - complications</topic><topic>Infections - mortality</topic><topic>Influenza</topic><topic>Injuries</topic><topic>Injury analysis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neurochemistry</topic><topic>Neuropsychology</topic><topic>Neurosciences</topic><topic>Pressure</topic><topic>Pressure Ulcer - complications</topic><topic>Pressure Ulcer - mortality</topic><topic>Prospective Studies</topic><topic>Rehabilitation</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Septicemia</topic><topic>Signs and symptoms</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - complications</topic><topic>Spinal Cord Injuries - mortality</topic><topic>Ulcers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao, Yue</creatorcontrib><creatorcontrib>DiPiro, Nicole</creatorcontrib><creatorcontrib>Krause, James S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Spinal cord</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Yue</au><au>DiPiro, Nicole</au><au>Krause, James S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Health factors and spinal cord injury: a prospective study of risk of cause-specific mortality</atitle><jtitle>Spinal cord</jtitle><stitle>Spinal Cord</stitle><addtitle>Spinal Cord</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>57</volume><issue>7</issue><spage>594</spage><epage>602</epage><pages>594-602</pages><issn>1362-4393</issn><eissn>1476-5624</eissn><abstract>Study design
Prospective cohort study.
Objectives:
Identify the risk and protective factors of all-cause and cause-specific mortality among persons with traumatic spinal cord injury (SCI).
Setting
Rehabilitation specialty hospital in the Southeastern United States.
Methods
A prospective cohort study was conducted with 3070 adults with traumatic SCI who were a minimum of 1 year post-injury at assessment. Prospective data were collected in 1997–1998 and 2007–2010, with mortality determined as of 31 December, 2016. The deceased were classified into six categories based on underlying cause of death: septicemia, pneumonia and influenza, cancer, heart and blood vessel diseases, unintentional injuries, and all other causes. The competing risk analysis strategy applied to each of the specific causes.
Results
There were a total of 803 observed deaths among the 2979 final study sample. After controlling for demographic and injury characteristics, general health, pressure ulcer history, and symptoms of infections were significantly associated with all-cause mortality. Except for cancer, they were also related with at least one of the specific causes of death, whereas orthopedic complications and subsequent injuries were unrelated to any cause.
Conclusions
Three health domains, global health, pressure ulcers, and symptoms of illness or infection, were significantly associated with mortality after SCI, and the patterns of association varied as a function of specific cause of death.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30804424</pmid><doi>10.1038/s41393-019-0264-6</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Spinal cord, 2019-07, Vol.57 (7), p.594-602 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 692/1807 692/499 Adult Anatomy Biomedical and Life Sciences Biomedicine Blood vessels Cancer Cohort Studies Complications Coronary artery disease Death Demographics Domains Female Global health Health risk assessment Health risks Health Status Heart Heart diseases Human Physiology Humans Infections Infections - complications Infections - mortality Influenza Injuries Injury analysis Male Middle Aged Mortality Neurochemistry Neuropsychology Neurosciences Pressure Pressure Ulcer - complications Pressure Ulcer - mortality Prospective Studies Rehabilitation Risk analysis Risk Factors Septicemia Signs and symptoms Spinal cord injuries Spinal Cord Injuries - complications Spinal Cord Injuries - mortality Ulcers |
| title | Health factors and spinal cord injury: a prospective study of risk of cause-specific mortality |
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