High tumor cell vimentin expression indicates prolonged survival in patients with ovarian malignant tumors
The main aims of the study were to investigate the expression of vimentin and its correlation with the overall survival (OS) of patients with malignant ovarian tumors, and the correlation between vimentin expression and tumor stroma characteristics. The study focused on 94 malignant ovarian tumors t...
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| Veröffentlicht in: | Ginekologia polska 2019, Vol.90 (1), p.11-19 |
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| creator | Szubert, Sebastian Koper, Krzysztof Dutsch-Wicherek, Magdalena Maria Jozwicki, Wojciech |
| description | The main aims of the study were to investigate the expression of vimentin and its correlation with the overall survival (OS) of patients with malignant ovarian tumors, and the correlation between vimentin expression and tumor stroma characteristics.
The study focused on 94 malignant ovarian tumors that had been collected from women who were treated in the Department of Gynecology and Oncology of the Lukaszczyk Oncological Center, Bydgoszcz, Poland. Vimentin expression was assessed in both the cancer cells (expression intensity and quantitative analysis) and the tumor stroma (expression intensity). Vimentin expression was analyzed according to both stromal cellularity and the clinicopatho- logical features of the disease.
Both high cancer cell vimentin expression intensity and high quantitative vimentin expression (up to and includ- ing 30% of cells) indicated a significantly prolonged OS. Low vimentin stromal expression was associated with prolonged OS, although the difference did not reach the level of significance. High tumor cell vimentin expression intensity was as- sociated with significantly higher vimentin stromal expression. High vimentin expression in the tumor stroma indicated a significantly higher cellularity of the tumor stroma. Vimentin expression in cancer cells and the tumor stroma were not dependent on the histopathological type, the tumor grade or the FIGO stageof the disease.
High cancer cell vimentin expression is associated with an improved OS of patients with malignant ovar- ian tumors. The expression of vimentin in ovarian malignancies may influence the structure of the tumor stroma. |
| doi_str_mv | 10.5603/GP.2019.0003 |
| format | Article |
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The study focused on 94 malignant ovarian tumors that had been collected from women who were treated in the Department of Gynecology and Oncology of the Lukaszczyk Oncological Center, Bydgoszcz, Poland. Vimentin expression was assessed in both the cancer cells (expression intensity and quantitative analysis) and the tumor stroma (expression intensity). Vimentin expression was analyzed according to both stromal cellularity and the clinicopatho- logical features of the disease.
Both high cancer cell vimentin expression intensity and high quantitative vimentin expression (up to and includ- ing 30% of cells) indicated a significantly prolonged OS. Low vimentin stromal expression was associated with prolonged OS, although the difference did not reach the level of significance. High tumor cell vimentin expression intensity was as- sociated with significantly higher vimentin stromal expression. High vimentin expression in the tumor stroma indicated a significantly higher cellularity of the tumor stroma. Vimentin expression in cancer cells and the tumor stroma were not dependent on the histopathological type, the tumor grade or the FIGO stageof the disease.
High cancer cell vimentin expression is associated with an improved OS of patients with malignant ovar- ian tumors. The expression of vimentin in ovarian malignancies may influence the structure of the tumor stroma.</description><identifier>ISSN: 0017-0011</identifier><identifier>EISSN: 2543-6767</identifier><identifier>DOI: 10.5603/GP.2019.0003</identifier><identifier>PMID: 30756366</identifier><language>eng</language><publisher>Poland: Wydawnictwo Via Medica</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cancer ; Cohort Studies ; Female ; Humans ; Middle Aged ; Ovarian cancer ; Ovarian Neoplasms - chemistry ; Ovarian Neoplasms - metabolism ; Ovarian Neoplasms - mortality ; Ovarian Neoplasms - pathology ; Ovaries ; Ovary - chemistry ; Ovary - metabolism ; Ovary - pathology ; Prognosis ; Tumor Microenvironment ; Tumors ; Vimentin - analysis ; Vimentin - metabolism</subject><ispartof>Ginekologia polska, 2019, Vol.90 (1), p.11-19</ispartof><rights>2019. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,866,4026,27930,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30756366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szubert, Sebastian</creatorcontrib><creatorcontrib>Koper, Krzysztof</creatorcontrib><creatorcontrib>Dutsch-Wicherek, Magdalena Maria</creatorcontrib><creatorcontrib>Jozwicki, Wojciech</creatorcontrib><title>High tumor cell vimentin expression indicates prolonged survival in patients with ovarian malignant tumors</title><title>Ginekologia polska</title><addtitle>Ginekol Pol</addtitle><description>The main aims of the study were to investigate the expression of vimentin and its correlation with the overall survival (OS) of patients with malignant ovarian tumors, and the correlation between vimentin expression and tumor stroma characteristics.
The study focused on 94 malignant ovarian tumors that had been collected from women who were treated in the Department of Gynecology and Oncology of the Lukaszczyk Oncological Center, Bydgoszcz, Poland. Vimentin expression was assessed in both the cancer cells (expression intensity and quantitative analysis) and the tumor stroma (expression intensity). Vimentin expression was analyzed according to both stromal cellularity and the clinicopatho- logical features of the disease.
Both high cancer cell vimentin expression intensity and high quantitative vimentin expression (up to and includ- ing 30% of cells) indicated a significantly prolonged OS. Low vimentin stromal expression was associated with prolonged OS, although the difference did not reach the level of significance. High tumor cell vimentin expression intensity was as- sociated with significantly higher vimentin stromal expression. High vimentin expression in the tumor stroma indicated a significantly higher cellularity of the tumor stroma. Vimentin expression in cancer cells and the tumor stroma were not dependent on the histopathological type, the tumor grade or the FIGO stageof the disease.
High cancer cell vimentin expression is associated with an improved OS of patients with malignant ovar- ian tumors. The expression of vimentin in ovarian malignancies may influence the structure of the tumor stroma.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - chemistry</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovarian Neoplasms - mortality</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovaries</subject><subject>Ovary - chemistry</subject><subject>Ovary - metabolism</subject><subject>Ovary - pathology</subject><subject>Prognosis</subject><subject>Tumor Microenvironment</subject><subject>Tumors</subject><subject>Vimentin - analysis</subject><subject>Vimentin - metabolism</subject><issn>0017-0011</issn><issn>2543-6767</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkD1PwzAQhi0EolXpxowssbCk-NvJiCpokSrBAHPkxG7rKnGC7QT497iiLCx3wz336rkD4BqjBReI3q9eFwThYoEQomdgSjijmZBCnoMpQlhmqeAJmIdwSAQSRJKiuAQTiiQXVIgpOKztbg_j0HYe1qZp4Ghb46J10Hz13oRgOwet07ZW0QTY-67p3M5oGAY_2lE1aQh7FW1aCvDTxj3sRuWtcrBVjd055eJvfLgCF1vVBDM_9Rl4f3p8W66zzcvqefmwyXrMWcxyrhkjGNcCbQ1BlSwwynMka6I4wZThinMh-FYIQwRlOleck0pXVUW1ohLTGbj7zU2yH4MJsWxtON6mnOmGUBKcC8xYjvOE3v5DD93gXbIrCRPJgiB2pG5O1FC1Rpe9t63y3-XfF-kPl2d0Pw</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Szubert, Sebastian</creator><creator>Koper, Krzysztof</creator><creator>Dutsch-Wicherek, Magdalena Maria</creator><creator>Jozwicki, Wojciech</creator><general>Wydawnictwo Via Medica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2019</creationdate><title>High tumor cell vimentin expression indicates prolonged survival in patients with ovarian malignant tumors</title><author>Szubert, Sebastian ; Koper, Krzysztof ; Dutsch-Wicherek, Magdalena Maria ; Jozwicki, Wojciech</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p154t-85d44211c60fe20b79108807c2a521341b55665f66e2634d8a552bdbbb3da3713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - chemistry</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Ovarian Neoplasms - mortality</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovaries</topic><topic>Ovary - chemistry</topic><topic>Ovary - metabolism</topic><topic>Ovary - pathology</topic><topic>Prognosis</topic><topic>Tumor Microenvironment</topic><topic>Tumors</topic><topic>Vimentin - analysis</topic><topic>Vimentin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szubert, Sebastian</creatorcontrib><creatorcontrib>Koper, Krzysztof</creatorcontrib><creatorcontrib>Dutsch-Wicherek, Magdalena Maria</creatorcontrib><creatorcontrib>Jozwicki, Wojciech</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Ginekologia polska</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szubert, Sebastian</au><au>Koper, Krzysztof</au><au>Dutsch-Wicherek, Magdalena Maria</au><au>Jozwicki, Wojciech</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High tumor cell vimentin expression indicates prolonged survival in patients with ovarian malignant tumors</atitle><jtitle>Ginekologia polska</jtitle><addtitle>Ginekol Pol</addtitle><date>2019</date><risdate>2019</risdate><volume>90</volume><issue>1</issue><spage>11</spage><epage>19</epage><pages>11-19</pages><issn>0017-0011</issn><eissn>2543-6767</eissn><abstract>The main aims of the study were to investigate the expression of vimentin and its correlation with the overall survival (OS) of patients with malignant ovarian tumors, and the correlation between vimentin expression and tumor stroma characteristics.
The study focused on 94 malignant ovarian tumors that had been collected from women who were treated in the Department of Gynecology and Oncology of the Lukaszczyk Oncological Center, Bydgoszcz, Poland. Vimentin expression was assessed in both the cancer cells (expression intensity and quantitative analysis) and the tumor stroma (expression intensity). Vimentin expression was analyzed according to both stromal cellularity and the clinicopatho- logical features of the disease.
Both high cancer cell vimentin expression intensity and high quantitative vimentin expression (up to and includ- ing 30% of cells) indicated a significantly prolonged OS. Low vimentin stromal expression was associated with prolonged OS, although the difference did not reach the level of significance. High tumor cell vimentin expression intensity was as- sociated with significantly higher vimentin stromal expression. High vimentin expression in the tumor stroma indicated a significantly higher cellularity of the tumor stroma. Vimentin expression in cancer cells and the tumor stroma were not dependent on the histopathological type, the tumor grade or the FIGO stageof the disease.
High cancer cell vimentin expression is associated with an improved OS of patients with malignant ovar- ian tumors. The expression of vimentin in ovarian malignancies may influence the structure of the tumor stroma.</abstract><cop>Poland</cop><pub>Wydawnictwo Via Medica</pub><pmid>30756366</pmid><doi>10.5603/GP.2019.0003</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Aged, 80 and over Cancer Cohort Studies Female Humans Middle Aged Ovarian cancer Ovarian Neoplasms - chemistry Ovarian Neoplasms - metabolism Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Ovaries Ovary - chemistry Ovary - metabolism Ovary - pathology Prognosis Tumor Microenvironment Tumors Vimentin - analysis Vimentin - metabolism |
| title | High tumor cell vimentin expression indicates prolonged survival in patients with ovarian malignant tumors |
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