Oncologic Effects of Primary Tumor-Sidedness on Patients with Stages 1–3 Colon Cancer: A Meta-Analysis
Background Previous studies comparing the oncologic outcomes of primary tumor-sidedness for patients with colon cancer have reported a worse prognosis for those with right-sided tumors. However, most of these studies evaluated patients with metastatic disease. Methods PubMed, EMBASE, and the Cochran...
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| Veröffentlicht in: | Annals of surgical oncology 2019-05, Vol.26 (5), p.1366-1375 |
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| creator | Ha, Gi Won Kim, Jong Hun Lee, Min Ro |
| description | Background
Previous studies comparing the oncologic outcomes of primary tumor-sidedness for patients with colon cancer have reported a worse prognosis for those with right-sided tumors. However, most of these studies evaluated patients with metastatic disease.
Methods
PubMed, EMBASE, and the Cochrane Library were searched for studies that assessed the effects of primary tumor-sidedness on survival outcomes for patients with stages 1, 2, and 3 colon cancer. The hazard ratio (HR) for primary tumor location was estimated for overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS).
Results
The inclusion criteria were met by 37 studies involving 581,542 patients. The patients with a right-sided tumor had better CSS (HR, 0.67; 95% confidence interval [CI], 0.56–0.80;
p
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| doi_str_mv | 10.1245/s10434-019-07164-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2186142415</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2185796372</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-c20967faa27ba231f0d8ba84fc8c0306f730b6956e48dde84cd59a63111246933</originalsourceid><addsrcrecordid>eNp9kc1OGzEUhS0EKiHtC3RRWWLDxsX_9rCLIiiVQImUdG05HjsMmnjAnhFi13foG_IkNUxKpS668pXvd499zwHgM8FfCeXiPBPMGUeYVAgrIjlSB2BCRLniUpPDUmOpUUWlOAYnOd9jTBTD4gM4ZlhjoXE1AXeL6Lq22zYOXobgXZ9hF-AyNTubnuF62HUJrZra19Hn0opwafvGx4I9Nf0dXPV26zMkLz9_MTgvQhHObXQ-XcAZvPW9RbNo2-fc5I_gKNg2-0_7cwp-XF2u59foZvHt-3x2gxxTokeO4kqqYC1VG0sZCbjWG6t5cNphhmUoG2xkJaTnuq695q4WlZWMkGKJrBibgrNR9yF1j4PPvdk12fm2tdF3QzaUaEk45cWnKTj9B73vhlT--0YJVUmmaKHoSLnU5Zx8MA-jO4Zg85qDGXMwJQfzloNRZejLXnrY7Hz9PvLH-AKwEcilFbc-_X37P7K_AXyPkfI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2185796372</pqid></control><display><type>article</type><title>Oncologic Effects of Primary Tumor-Sidedness on Patients with Stages 1–3 Colon Cancer: A Meta-Analysis</title><source>SpringerLink Journals - AutoHoldings</source><creator>Ha, Gi Won ; Kim, Jong Hun ; Lee, Min Ro</creator><creatorcontrib>Ha, Gi Won ; Kim, Jong Hun ; Lee, Min Ro</creatorcontrib><description>Background
Previous studies comparing the oncologic outcomes of primary tumor-sidedness for patients with colon cancer have reported a worse prognosis for those with right-sided tumors. However, most of these studies evaluated patients with metastatic disease.
Methods
PubMed, EMBASE, and the Cochrane Library were searched for studies that assessed the effects of primary tumor-sidedness on survival outcomes for patients with stages 1, 2, and 3 colon cancer. The hazard ratio (HR) for primary tumor location was estimated for overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS).
Results
The inclusion criteria were met by 37 studies involving 581,542 patients. The patients with a right-sided tumor had better CSS (HR, 0.67; 95% confidence interval [CI], 0.56–0.80;
p
< 0.0001) among those with stage 1 cancer as well as better OS (HR, 0.89; 95% CI 0.86–0.92;
I
2
= 19%) and CSS (HR, 0.78; 95% CI 0.70–0.86;
I
2
= 78%) among those with stage 2 cancer. In contrast, among the patients with stage 3 cancer, those with a right-sided tumor had worse OS (HR, 1.12; 95% CI 1.04–1.20;
p
= 0.002), CSS (HR, 1.05; 95% CI 1.01–1.10;
p
= 0.02), and DFS (HR, 1.32; 95% CI 1.07–1.63;
p
= 0.008).
Conclusions
Primary tumor location may be a prognostic factor for patients with non-metastatic colon cancer. The prognosis for patients with right-sided tumor may be better for those with stage 1 or 2 cancer, but worse for those with stage 3 cancer.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-019-07164-7</identifier><identifier>PMID: 30805809</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Colon cancer ; Colorectal Cancer ; Medical prognosis ; Medicine ; Medicine & Public Health ; Meta-analysis ; Metastases ; Metastasis ; Oncology ; Prognosis ; Surgery ; Surgical Oncology ; Survival ; Tumors</subject><ispartof>Annals of surgical oncology, 2019-05, Vol.26 (5), p.1366-1375</ispartof><rights>Society of Surgical Oncology 2019</rights><rights>Annals of Surgical Oncology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-c20967faa27ba231f0d8ba84fc8c0306f730b6956e48dde84cd59a63111246933</citedby><cites>FETCH-LOGICAL-c375t-c20967faa27ba231f0d8ba84fc8c0306f730b6956e48dde84cd59a63111246933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-019-07164-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-019-07164-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30805809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ha, Gi Won</creatorcontrib><creatorcontrib>Kim, Jong Hun</creatorcontrib><creatorcontrib>Lee, Min Ro</creatorcontrib><title>Oncologic Effects of Primary Tumor-Sidedness on Patients with Stages 1–3 Colon Cancer: A Meta-Analysis</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Previous studies comparing the oncologic outcomes of primary tumor-sidedness for patients with colon cancer have reported a worse prognosis for those with right-sided tumors. However, most of these studies evaluated patients with metastatic disease.
Methods
PubMed, EMBASE, and the Cochrane Library were searched for studies that assessed the effects of primary tumor-sidedness on survival outcomes for patients with stages 1, 2, and 3 colon cancer. The hazard ratio (HR) for primary tumor location was estimated for overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS).
Results
The inclusion criteria were met by 37 studies involving 581,542 patients. The patients with a right-sided tumor had better CSS (HR, 0.67; 95% confidence interval [CI], 0.56–0.80;
p
< 0.0001) among those with stage 1 cancer as well as better OS (HR, 0.89; 95% CI 0.86–0.92;
I
2
= 19%) and CSS (HR, 0.78; 95% CI 0.70–0.86;
I
2
= 78%) among those with stage 2 cancer. In contrast, among the patients with stage 3 cancer, those with a right-sided tumor had worse OS (HR, 1.12; 95% CI 1.04–1.20;
p
= 0.002), CSS (HR, 1.05; 95% CI 1.01–1.10;
p
= 0.02), and DFS (HR, 1.32; 95% CI 1.07–1.63;
p
= 0.008).
Conclusions
Primary tumor location may be a prognostic factor for patients with non-metastatic colon cancer. The prognosis for patients with right-sided tumor may be better for those with stage 1 or 2 cancer, but worse for those with stage 3 cancer.</description><subject>Colon cancer</subject><subject>Colorectal Cancer</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival</subject><subject>Tumors</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc1OGzEUhS0EKiHtC3RRWWLDxsX_9rCLIiiVQImUdG05HjsMmnjAnhFi13foG_IkNUxKpS668pXvd499zwHgM8FfCeXiPBPMGUeYVAgrIjlSB2BCRLniUpPDUmOpUUWlOAYnOd9jTBTD4gM4ZlhjoXE1AXeL6Lq22zYOXobgXZ9hF-AyNTubnuF62HUJrZra19Hn0opwafvGx4I9Nf0dXPV26zMkLz9_MTgvQhHObXQ-XcAZvPW9RbNo2-fc5I_gKNg2-0_7cwp-XF2u59foZvHt-3x2gxxTokeO4kqqYC1VG0sZCbjWG6t5cNphhmUoG2xkJaTnuq695q4WlZWMkGKJrBibgrNR9yF1j4PPvdk12fm2tdF3QzaUaEk45cWnKTj9B73vhlT--0YJVUmmaKHoSLnU5Zx8MA-jO4Zg85qDGXMwJQfzloNRZejLXnrY7Hz9PvLH-AKwEcilFbc-_X37P7K_AXyPkfI</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Ha, Gi Won</creator><creator>Kim, Jong Hun</creator><creator>Lee, Min Ro</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190501</creationdate><title>Oncologic Effects of Primary Tumor-Sidedness on Patients with Stages 1–3 Colon Cancer: A Meta-Analysis</title><author>Ha, Gi Won ; Kim, Jong Hun ; Lee, Min Ro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-c20967faa27ba231f0d8ba84fc8c0306f730b6956e48dde84cd59a63111246933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Colon cancer</topic><topic>Colorectal Cancer</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ha, Gi Won</creatorcontrib><creatorcontrib>Kim, Jong Hun</creatorcontrib><creatorcontrib>Lee, Min Ro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ha, Gi Won</au><au>Kim, Jong Hun</au><au>Lee, Min Ro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oncologic Effects of Primary Tumor-Sidedness on Patients with Stages 1–3 Colon Cancer: A Meta-Analysis</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>26</volume><issue>5</issue><spage>1366</spage><epage>1375</epage><pages>1366-1375</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Previous studies comparing the oncologic outcomes of primary tumor-sidedness for patients with colon cancer have reported a worse prognosis for those with right-sided tumors. However, most of these studies evaluated patients with metastatic disease.
Methods
PubMed, EMBASE, and the Cochrane Library were searched for studies that assessed the effects of primary tumor-sidedness on survival outcomes for patients with stages 1, 2, and 3 colon cancer. The hazard ratio (HR) for primary tumor location was estimated for overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS).
Results
The inclusion criteria were met by 37 studies involving 581,542 patients. The patients with a right-sided tumor had better CSS (HR, 0.67; 95% confidence interval [CI], 0.56–0.80;
p
< 0.0001) among those with stage 1 cancer as well as better OS (HR, 0.89; 95% CI 0.86–0.92;
I
2
= 19%) and CSS (HR, 0.78; 95% CI 0.70–0.86;
I
2
= 78%) among those with stage 2 cancer. In contrast, among the patients with stage 3 cancer, those with a right-sided tumor had worse OS (HR, 1.12; 95% CI 1.04–1.20;
p
= 0.002), CSS (HR, 1.05; 95% CI 1.01–1.10;
p
= 0.02), and DFS (HR, 1.32; 95% CI 1.07–1.63;
p
= 0.008).
Conclusions
Primary tumor location may be a prognostic factor for patients with non-metastatic colon cancer. The prognosis for patients with right-sided tumor may be better for those with stage 1 or 2 cancer, but worse for those with stage 3 cancer.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30805809</pmid><doi>10.1245/s10434-019-07164-7</doi><tpages>10</tpages></addata></record> |
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| ispartof | Annals of surgical oncology, 2019-05, Vol.26 (5), p.1366-1375 |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Colon cancer Colorectal Cancer Medical prognosis Medicine Medicine & Public Health Meta-analysis Metastases Metastasis Oncology Prognosis Surgery Surgical Oncology Survival Tumors |
| title | Oncologic Effects of Primary Tumor-Sidedness on Patients with Stages 1–3 Colon Cancer: A Meta-Analysis |
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