Ensembles from Ordered and Disordered Proteins Reveal Similar Structural Constraints during Evolution

The conformations accessible to proteins are determined by the inter-residue interactions between amino acid residues. During evolution, structural constraints that are required for protein function providing biologically relevant information can exist. Here, we studied the proportion of sites evolv...

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Veröffentlicht in:	Journal of molecular biology 2019-03, Vol.431 (6), p.1298-1307
Hauptverfasser:	Marchetti, Julia, Monzon, Alexander Miguel, Tosatto, Silvio C.E., Parisi, Gustavo, Fornasari, María Silvina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals conformational diversity disordered proteins Evolution, Molecular Humans Intrinsically Disordered Proteins - chemistry Molecular Dynamics Simulation Protein Conformation protein ensemble protein evolution Proteins - chemistry
Online-Zugang:	Volltext
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