Synthesis of 2-,4,-6-, and/or 7-substituted quinoline derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors and anticancer agents: 3D QSAR-assisted design

[Display omitted] Following our research for human dihydroorotate dehydrogenase (hDHODH) inhibitors as anticancer agents, herein we describe 3D QSAR-based design, synthesis and in vitro screening of 2-,4,-6-, and/or 7-substituted quinoline derivatives as hDHODH inhibitors and anticancer agents. We h...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2019-04, Vol.29 (7), p.917-922
Hauptverfasser:	Vyas, Vivek K., Qureshi, Gulamnizami, Oza, Drashti, Patel, Hardik, Parmar, Krupali, Patel, Palak, Ghate, Manjunath D.
Format:	Artikel
Sprache:	eng
Schlagworte:	3D QSAR Anticancer agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Drug Design hDHODH inhibitors Human dihydroorotate dehydrogenase (hDHODH) Humans Models, Molecular Molecular Structure Oxidoreductases Acting on CH-CH Group Donors - antagonists & inhibitors Quantitative Structure-Activity Relationship Quinolines - chemistry Quinolines - pharmacology Substituted quinolines
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