Tadalafil improves bladder dysfunction and object recognition in rats with pelvic venous congestion
Objectives To examine the effects of tadalafil on bladder function and object recognition ability in rats with alterations in urinary frequency and locomotor activity as a result of pelvic venous congestion. Methods A total of 48 female rats were divided into three groups (sham, pelvic venous conges...
Gespeichert in:
| Veröffentlicht in: | International journal of urology 2019-05, Vol.26 (5), p.578-585 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 585 |
|---|---|
| container_issue | 5 |
| container_start_page | 578 |
| container_title | International journal of urology |
| container_volume | 26 |
| creator | Nishijima, Saori Sugaya, Kimio Kadekawa, Katsumi Ashitomi, Katsuhiro Ueda, Tomoyuki Yamamoto, Hideyuki |
| description | Objectives
To examine the effects of tadalafil on bladder function and object recognition ability in rats with alterations in urinary frequency and locomotor activity as a result of pelvic venous congestion.
Methods
A total of 48 female rats were divided into three groups (sham, pelvic venous congestion and pelvic venous congestion/tadalafil groups). In the pelvic venous congestion and pelvic venous congestion/tadalafil groups, the bilateral common iliac veins and uterine veins were ligated under anesthesia. Rats in the pelvic venous congestion/tadalafil group received a diet containing tadalafil, and the other rats were fed a normal diet. After 4 weeks, rats underwent analysis of voiding behavior, locomotor activity, a novel object recognition test, continuous cystometry, measurement of plasma monoamines, and measurement of plasma and urinary nitric oxide metabolites. Expression of nitric oxide synthase messenger ribonucleic acid in the bladder wall was also assessed, along with histological examination of the bladder.
Results
Rats with pelvic venous congestion showed a higher urinary frequency, lower locomotor activity, and lower plasma and urinary nitric oxide levels than sham rats. The bladder wall endothelial nitric oxide synthase messenger ribonucleic acid level was low and object recognition was impaired. Pelvic venous congestion/tadalafil rats showed improvement in locomotor activity, bladder function and object recognition compared with pelvic venous congestion rats, as well as elevation of plasma and urinary nitric oxide, plasma monoamines, and bladder neuronal nitric oxide synthase messenger ribonucleic acid expression. Bladder wall vascularity was greater in pelvic venous congestion/tadalafil rats compared with sham rats.
Conclusions
In rats with pelvic venous congestion, tadalafil might improve bladder function and the general condition by increasing blood flow to the bladder and brain, and by increasing dopamine levels. |
| doi_str_mv | 10.1111/iju.13932 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2185875056</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2213550004</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4122-dbbedb17cde93e70ec325add9f48488a382e1ef45bc114404f6eba8dc1e5bf3</originalsourceid><addsrcrecordid>eNp1kM1PGzEQxS1UBGnKgX-gstRLe9jg8UfiPVaoLUFIHKBnyx-z1NHGm9rZoPz3NQR6QGIuI41-evPeI-Qc2AzqXMTVOAPRCn5EJiAlbziT_AOZsBbaRsOCn5KPpawYA8FBn5BTwTQDrWBC_L0Ntrdd7Glcb_Kww0Jdb0PATMO-dGPy2zgkalOgg1uh39KMfnhI8fkcE812W-hj3P6hG-x30dMdpmEs1A_pAcsT9Ykcd7YvePayp-Tu54_7y6vm5vbX8vL7TeMlcN4E5zA4WPiArcAFQy-4qk7aTmqptRWaI2AnlfNQUzLZzdFZHTygcp2Ykq8H1Zri71g_m3UsHvveJqx-TE2u9EIxNa_olzfoahhzqt4M5yCUYozJSn07UD4PpWTszCbHtc17A8w89W5q7-a598p-flEc3RrDf_K16ApcHIDH2OP-fSWzvP59kPwHE7yOaQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2213550004</pqid></control><display><type>article</type><title>Tadalafil improves bladder dysfunction and object recognition in rats with pelvic venous congestion</title><source>Wiley Online Library All Journals</source><creator>Nishijima, Saori ; Sugaya, Kimio ; Kadekawa, Katsumi ; Ashitomi, Katsuhiro ; Ueda, Tomoyuki ; Yamamoto, Hideyuki</creator><creatorcontrib>Nishijima, Saori ; Sugaya, Kimio ; Kadekawa, Katsumi ; Ashitomi, Katsuhiro ; Ueda, Tomoyuki ; Yamamoto, Hideyuki</creatorcontrib><description>Objectives
To examine the effects of tadalafil on bladder function and object recognition ability in rats with alterations in urinary frequency and locomotor activity as a result of pelvic venous congestion.
Methods
A total of 48 female rats were divided into three groups (sham, pelvic venous congestion and pelvic venous congestion/tadalafil groups). In the pelvic venous congestion and pelvic venous congestion/tadalafil groups, the bilateral common iliac veins and uterine veins were ligated under anesthesia. Rats in the pelvic venous congestion/tadalafil group received a diet containing tadalafil, and the other rats were fed a normal diet. After 4 weeks, rats underwent analysis of voiding behavior, locomotor activity, a novel object recognition test, continuous cystometry, measurement of plasma monoamines, and measurement of plasma and urinary nitric oxide metabolites. Expression of nitric oxide synthase messenger ribonucleic acid in the bladder wall was also assessed, along with histological examination of the bladder.
Results
Rats with pelvic venous congestion showed a higher urinary frequency, lower locomotor activity, and lower plasma and urinary nitric oxide levels than sham rats. The bladder wall endothelial nitric oxide synthase messenger ribonucleic acid level was low and object recognition was impaired. Pelvic venous congestion/tadalafil rats showed improvement in locomotor activity, bladder function and object recognition compared with pelvic venous congestion rats, as well as elevation of plasma and urinary nitric oxide, plasma monoamines, and bladder neuronal nitric oxide synthase messenger ribonucleic acid expression. Bladder wall vascularity was greater in pelvic venous congestion/tadalafil rats compared with sham rats.
Conclusions
In rats with pelvic venous congestion, tadalafil might improve bladder function and the general condition by increasing blood flow to the bladder and brain, and by increasing dopamine levels.</description><identifier>ISSN: 0919-8172</identifier><identifier>EISSN: 1442-2042</identifier><identifier>DOI: 10.1111/iju.13932</identifier><identifier>PMID: 30801851</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Anesthesia ; Animal behavior ; Bladder ; Blood flow ; Diet ; Dopamine ; Locomotor activity ; Metabolites ; Monoamines ; Nitric oxide ; Nitric-oxide synthase ; Pattern recognition ; pelvic venous congestion ; Plasma ; Rodents ; tadalafil ; urinary frequency ; Uterus ; Veins</subject><ispartof>International journal of urology, 2019-05, Vol.26 (5), p.578-585</ispartof><rights>2019 The Japanese Urological Association</rights><rights>2019 The Japanese Urological Association.</rights><rights>Copyright © 2019 The Japanese Urological Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4122-dbbedb17cde93e70ec325add9f48488a382e1ef45bc114404f6eba8dc1e5bf3</citedby><cites>FETCH-LOGICAL-c4122-dbbedb17cde93e70ec325add9f48488a382e1ef45bc114404f6eba8dc1e5bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiju.13932$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiju.13932$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30801851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishijima, Saori</creatorcontrib><creatorcontrib>Sugaya, Kimio</creatorcontrib><creatorcontrib>Kadekawa, Katsumi</creatorcontrib><creatorcontrib>Ashitomi, Katsuhiro</creatorcontrib><creatorcontrib>Ueda, Tomoyuki</creatorcontrib><creatorcontrib>Yamamoto, Hideyuki</creatorcontrib><title>Tadalafil improves bladder dysfunction and object recognition in rats with pelvic venous congestion</title><title>International journal of urology</title><addtitle>Int J Urol</addtitle><description>Objectives
To examine the effects of tadalafil on bladder function and object recognition ability in rats with alterations in urinary frequency and locomotor activity as a result of pelvic venous congestion.
Methods
A total of 48 female rats were divided into three groups (sham, pelvic venous congestion and pelvic venous congestion/tadalafil groups). In the pelvic venous congestion and pelvic venous congestion/tadalafil groups, the bilateral common iliac veins and uterine veins were ligated under anesthesia. Rats in the pelvic venous congestion/tadalafil group received a diet containing tadalafil, and the other rats were fed a normal diet. After 4 weeks, rats underwent analysis of voiding behavior, locomotor activity, a novel object recognition test, continuous cystometry, measurement of plasma monoamines, and measurement of plasma and urinary nitric oxide metabolites. Expression of nitric oxide synthase messenger ribonucleic acid in the bladder wall was also assessed, along with histological examination of the bladder.
Results
Rats with pelvic venous congestion showed a higher urinary frequency, lower locomotor activity, and lower plasma and urinary nitric oxide levels than sham rats. The bladder wall endothelial nitric oxide synthase messenger ribonucleic acid level was low and object recognition was impaired. Pelvic venous congestion/tadalafil rats showed improvement in locomotor activity, bladder function and object recognition compared with pelvic venous congestion rats, as well as elevation of plasma and urinary nitric oxide, plasma monoamines, and bladder neuronal nitric oxide synthase messenger ribonucleic acid expression. Bladder wall vascularity was greater in pelvic venous congestion/tadalafil rats compared with sham rats.
Conclusions
In rats with pelvic venous congestion, tadalafil might improve bladder function and the general condition by increasing blood flow to the bladder and brain, and by increasing dopamine levels.</description><subject>Anesthesia</subject><subject>Animal behavior</subject><subject>Bladder</subject><subject>Blood flow</subject><subject>Diet</subject><subject>Dopamine</subject><subject>Locomotor activity</subject><subject>Metabolites</subject><subject>Monoamines</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>Pattern recognition</subject><subject>pelvic venous congestion</subject><subject>Plasma</subject><subject>Rodents</subject><subject>tadalafil</subject><subject>urinary frequency</subject><subject>Uterus</subject><subject>Veins</subject><issn>0919-8172</issn><issn>1442-2042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kM1PGzEQxS1UBGnKgX-gstRLe9jg8UfiPVaoLUFIHKBnyx-z1NHGm9rZoPz3NQR6QGIuI41-evPeI-Qc2AzqXMTVOAPRCn5EJiAlbziT_AOZsBbaRsOCn5KPpawYA8FBn5BTwTQDrWBC_L0Ntrdd7Glcb_Kww0Jdb0PATMO-dGPy2zgkalOgg1uh39KMfnhI8fkcE812W-hj3P6hG-x30dMdpmEs1A_pAcsT9Ykcd7YvePayp-Tu54_7y6vm5vbX8vL7TeMlcN4E5zA4WPiArcAFQy-4qk7aTmqptRWaI2AnlfNQUzLZzdFZHTygcp2Ykq8H1Zri71g_m3UsHvveJqx-TE2u9EIxNa_olzfoahhzqt4M5yCUYozJSn07UD4PpWTszCbHtc17A8w89W5q7-a598p-flEc3RrDf_K16ApcHIDH2OP-fSWzvP59kPwHE7yOaQ</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Nishijima, Saori</creator><creator>Sugaya, Kimio</creator><creator>Kadekawa, Katsumi</creator><creator>Ashitomi, Katsuhiro</creator><creator>Ueda, Tomoyuki</creator><creator>Yamamoto, Hideyuki</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>201905</creationdate><title>Tadalafil improves bladder dysfunction and object recognition in rats with pelvic venous congestion</title><author>Nishijima, Saori ; Sugaya, Kimio ; Kadekawa, Katsumi ; Ashitomi, Katsuhiro ; Ueda, Tomoyuki ; Yamamoto, Hideyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4122-dbbedb17cde93e70ec325add9f48488a382e1ef45bc114404f6eba8dc1e5bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anesthesia</topic><topic>Animal behavior</topic><topic>Bladder</topic><topic>Blood flow</topic><topic>Diet</topic><topic>Dopamine</topic><topic>Locomotor activity</topic><topic>Metabolites</topic><topic>Monoamines</topic><topic>Nitric oxide</topic><topic>Nitric-oxide synthase</topic><topic>Pattern recognition</topic><topic>pelvic venous congestion</topic><topic>Plasma</topic><topic>Rodents</topic><topic>tadalafil</topic><topic>urinary frequency</topic><topic>Uterus</topic><topic>Veins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishijima, Saori</creatorcontrib><creatorcontrib>Sugaya, Kimio</creatorcontrib><creatorcontrib>Kadekawa, Katsumi</creatorcontrib><creatorcontrib>Ashitomi, Katsuhiro</creatorcontrib><creatorcontrib>Ueda, Tomoyuki</creatorcontrib><creatorcontrib>Yamamoto, Hideyuki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishijima, Saori</au><au>Sugaya, Kimio</au><au>Kadekawa, Katsumi</au><au>Ashitomi, Katsuhiro</au><au>Ueda, Tomoyuki</au><au>Yamamoto, Hideyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tadalafil improves bladder dysfunction and object recognition in rats with pelvic venous congestion</atitle><jtitle>International journal of urology</jtitle><addtitle>Int J Urol</addtitle><date>2019-05</date><risdate>2019</risdate><volume>26</volume><issue>5</issue><spage>578</spage><epage>585</epage><pages>578-585</pages><issn>0919-8172</issn><eissn>1442-2042</eissn><abstract>Objectives
To examine the effects of tadalafil on bladder function and object recognition ability in rats with alterations in urinary frequency and locomotor activity as a result of pelvic venous congestion.
Methods
A total of 48 female rats were divided into three groups (sham, pelvic venous congestion and pelvic venous congestion/tadalafil groups). In the pelvic venous congestion and pelvic venous congestion/tadalafil groups, the bilateral common iliac veins and uterine veins were ligated under anesthesia. Rats in the pelvic venous congestion/tadalafil group received a diet containing tadalafil, and the other rats were fed a normal diet. After 4 weeks, rats underwent analysis of voiding behavior, locomotor activity, a novel object recognition test, continuous cystometry, measurement of plasma monoamines, and measurement of plasma and urinary nitric oxide metabolites. Expression of nitric oxide synthase messenger ribonucleic acid in the bladder wall was also assessed, along with histological examination of the bladder.
Results
Rats with pelvic venous congestion showed a higher urinary frequency, lower locomotor activity, and lower plasma and urinary nitric oxide levels than sham rats. The bladder wall endothelial nitric oxide synthase messenger ribonucleic acid level was low and object recognition was impaired. Pelvic venous congestion/tadalafil rats showed improvement in locomotor activity, bladder function and object recognition compared with pelvic venous congestion rats, as well as elevation of plasma and urinary nitric oxide, plasma monoamines, and bladder neuronal nitric oxide synthase messenger ribonucleic acid expression. Bladder wall vascularity was greater in pelvic venous congestion/tadalafil rats compared with sham rats.
Conclusions
In rats with pelvic venous congestion, tadalafil might improve bladder function and the general condition by increasing blood flow to the bladder and brain, and by increasing dopamine levels.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30801851</pmid><doi>10.1111/iju.13932</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0919-8172 |
| ispartof | International journal of urology, 2019-05, Vol.26 (5), p.578-585 |
| issn | 0919-8172 1442-2042 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2185875056 |
| source | Wiley Online Library All Journals |
| subjects | Anesthesia Animal behavior Bladder Blood flow Diet Dopamine Locomotor activity Metabolites Monoamines Nitric oxide Nitric-oxide synthase Pattern recognition pelvic venous congestion Plasma Rodents tadalafil urinary frequency Uterus Veins |
| title | Tadalafil improves bladder dysfunction and object recognition in rats with pelvic venous congestion |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T17%3A36%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tadalafil%20improves%20bladder%20dysfunction%20and%20object%20recognition%20in%20rats%20with%20pelvic%20venous%20congestion&rft.jtitle=International%20journal%20of%20urology&rft.au=Nishijima,%20Saori&rft.date=2019-05&rft.volume=26&rft.issue=5&rft.spage=578&rft.epage=585&rft.pages=578-585&rft.issn=0919-8172&rft.eissn=1442-2042&rft_id=info:doi/10.1111/iju.13932&rft_dat=%3Cproquest_cross%3E2213550004%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2213550004&rft_id=info:pmid/30801851&rfr_iscdi=true |