The interleukin-17 G-197A polymorphism is associated with cyclosporine metabolism and transplant rejection in liver transplant recipients

This study aimed to investigate the effect of and mechanism involved in the SNP on cyclosporine metabolism and outcomes of liver transplantation (LT). The genotype, IL-17 expression, postoperative outcome and cyclosporine concentration were reviewed in 106 LT recipients. The functional relevance of...

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Veröffentlicht in:	Pharmacogenomics 2019-04, Vol.20 (6), p.447-456
Hauptverfasser:	Sun, Bo, Gao, Junwei, Shi, Weifeng, Guo, Yankun, Fan, Junwei, Zhang, Jigang, Li, Xiaoyu, Liu, Gaolin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged cyclosporine Cyclosporine - metabolism Cyclosporins Cytochrome Cytochrome P-450 CYP3A - genetics Cytokines Deoxyribonucleic acid Disease DNA Down-Regulation - genetics Drug dosages Female Gene expression Gene polymorphism Genotype Graft rejection Graft Rejection - genetics Graft Rejection - metabolism Humans IL-17 Immunology Interleukin 17 Interleukin-17 - genetics Liver Liver transplantation Liver Transplantation - methods Liver transplants Male Metabolism Middle Aged mRNA Plasmids Polymorphism Polymorphism, Single Nucleotide - genetics Pregnane X Receptor - genetics Proteins Recombinant Proteins - genetics RNA, Messenger - genetics Single-nucleotide polymorphism Studies Transplant Recipients Transplants & implants Tuberculosis Up-Regulation - genetics Western blotting Young Adult
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