Induction of Th2-related immune responses and production of systemic IgA in mice intranasally immunized with Brucella abortus malate dehydrogenase loaded chitosan nanoparticles

[Display omitted] The aim of this study was to investigate the induction of mucosal immune responses by an important Brucella abortus antigen, malate dehydrogenase (Mdh), loaded in mucoadhesive chitosan nanoparticles (CNs) and immunized intranasally in a BALB/c mouse model. The production of cytokin...

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Veröffentlicht in:	Vaccine 2019-03, Vol.37 (12), p.1554-1564
Hauptverfasser:	Soh, Sang Hee, Shim, Soojin, Im, Young Bin, Park, Hong-Tae, Cho, Chong-Su, Yoo, Han Sang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Brucella abortus Brucellosis Chitosan Chitosan nanoparticles Dehydrogenases Drug delivery systems Immune response Immunization Immunoglobulin A Infections Lymphocytes T Malate dehydrogenase Mucosal immune response Mucous membrane Nanoparticles Nasal immunization Proteins Vaccines
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