Mechanism of Supersaturation Suppression in Dissolution Process of Acidic Drug Salt

Supersaturable active pharmaceutical ingredients (sAPI), such as salts, cocrystals, and amorphous solids, can form supersaturated solutions after dissolving in the gastrointestinal fluids. However, there are cases in which supersaturation is not observed in an in vitro nonsink dissolution test. The...

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Veröffentlicht in:	Molecular pharmaceutics 2019-04, Vol.16 (4), p.1669-1677
Hauptverfasser:	Oki, Jumpei, Watanabe, Daiju, Uekusa, Taiga, Sugano, Kiyohiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids - chemistry Chemical Precipitation Crystallization Diclofenac - chemistry Drug Compounding Hydrogen-Ion Concentration Salts - chemistry Solubility
Online-Zugang:	Volltext
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