A C-X-C Chemokine Receptor Type 2-Dominated Cross-talk between Tumor Cells and Macrophages Drives Gastric Cancer Metastasis

C-X-C chemokine receptor type 2 (CXCR2) is a key regulator that drives immune suppression and inflammation in tumor microenvironment. CXCR2-targeted therapy has shown promising results in several solid tumors. However, the underlying mechanism of CXCR2-mediated cross-talk between gastric cancer cell...

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Veröffentlicht in:	Clinical cancer research 2019-06, Vol.25 (11), p.3317-3328
Hauptverfasser:	Zhou, Zhijun, Xia, Guanggai, Xiang, Zhen, Liu, Mingyang, Wei, Zhewei, Yan, Jie, Chen, Wei, Zhu, Jintao, Awasthi, Niranjan, Sun, Xiaotian, Fung, Kar-Ming, He, Yulong, Li, Min, Zhang, Changhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Communication Cell Line, Tumor Cell Movement - genetics Chemokine CXCL1 - metabolism Chemokine CXCL5 - metabolism Coculture Techniques Disease Models, Animal Disease Progression Gene Expression Humans Macrophages - metabolism Macrophages - pathology Mice Models, Biological Neoplasm Metastasis Neoplasm Staging Prognosis Receptors, Interleukin-8B - genetics Receptors, Interleukin-8B - metabolism Signal Transduction STAT3 Transcription Factor - metabolism Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - mortality Stomach Neoplasms - pathology Tumor Microenvironment Xenograft Model Antitumor Assays
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