Mesenchymal stem cell basic research and applications in dog medicine
The stem cells, owing to their special characteristics like self‐renewal, multiplication, homing, immunomodulation, anti‐inflammatory, and dedifferentiation are considered to carry an “all‐in‐one‐solution” for diverse clinical problems. However, the limited understanding of cellular physiology curre...
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| Veröffentlicht in: | Journal of cellular physiology 2019-10, Vol.234 (10), p.16779-16811 |
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| container_end_page | 16811 |
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| container_issue | 10 |
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| container_title | Journal of cellular physiology |
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| creator | Gugjoo, Mudasir Bashir Amarpal, Amarpal Sharma, Gutulla Taru |
| description | The stem cells, owing to their special characteristics like self‐renewal, multiplication, homing, immunomodulation, anti‐inflammatory, and dedifferentiation are considered to carry an “all‐in‐one‐solution” for diverse clinical problems. However, the limited understanding of cellular physiology currently limits their definitive therapeutic use. Among various stem cell types, currently mesenchymal stem cells are extensively studied for dog clinical applications owing to their readily available sources, easy harvesting, and ability to differentiate both into mesodermal, as well as extramesodermal tissues. The isolated, culture expanded, and characterized cells have been applied both at preclinical as well as clinical settings in dogs with variable but mostly positive results. The results, though positive, are currently inconclusive and demands further intensive research on the properties and their dependence on the applications. Further, numerous clinical conditions of dog resemble to that of human counterparts and thus, if proved rewarding in the former may act as basis of therapy for the latter. The current review throws some light on dog mesenchymal stem cell properties and their potential therapeutic applications. |
| doi_str_mv | 10.1002/jcp.28348 |
| format | Article |
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However, the limited understanding of cellular physiology currently limits their definitive therapeutic use. Among various stem cell types, currently mesenchymal stem cells are extensively studied for dog clinical applications owing to their readily available sources, easy harvesting, and ability to differentiate both into mesodermal, as well as extramesodermal tissues. The isolated, culture expanded, and characterized cells have been applied both at preclinical as well as clinical settings in dogs with variable but mostly positive results. The results, though positive, are currently inconclusive and demands further intensive research on the properties and their dependence on the applications. Further, numerous clinical conditions of dog resemble to that of human counterparts and thus, if proved rewarding in the former may act as basis of therapy for the latter. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Cell culture Cell self-renewal characterization clinical applications Dependence dog Dog Diseases - therapy Dogs Homing Immunomodulation Inflammation Mesenchymal Stem Cell Transplantation - veterinary Mesenchymal stem cells Mesenchymal Stem Cells - physiology Mesenchyme Multiplication musculoskeletal soft tissue Stem cells Therapeutic applications Tissue engineering |
| title | Mesenchymal stem cell basic research and applications in dog medicine |
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