Characterization of novel kainic acid analogs as inhibitors of select microglial functions

Alzheimer's disease (AD) is characterized by abnormal accumulation of extracellular amyloid beta protein (Aβ) plaques and intracellular neurofibrillary tangles, as well as by a state of chronic inflammation in the central nervous system (CNS). Adverse activation of microglia, the brain immune c...

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Veröffentlicht in:	European journal of pharmacology 2019-05, Vol.851, p.25-35
Hauptverfasser:	Alford, Morgan A., Tian, Zhenlin, Menard, Frederic, Klegeris, Andis
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldose reductase Anti-inflammatory drugs Neurodegenerative disease Neuroinflammation Neuroprotection Zopolrestat
Online-Zugang:	Volltext
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