Liposome formulations of o-carborane for the boron neutron capture therapy of cancer
Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80–100 nm) of dipalmitoyl-phosphatid...
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| Veröffentlicht in: | Biophysical chemistry 2019-04, Vol.247, p.25-33 |
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| container_title | Biophysical chemistry |
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| creator | Olusanya, Temidayo O.B. Calabrese, Gianpiero Fatouros, Dimitrios G. Tsibouklis, John Smith, James R. |
| description | Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80–100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.
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•Liposomes containing carborane for Boron Neutron Capture Therapy have been produced.•Liposomes have diameters of 80–100 nm, in the range for crossing the blood-brain-barrier.•Liposomes are stable in serum as reflected by retention experiments. |
| doi_str_mv | 10.1016/j.bpc.2019.01.003 |
| format | Article |
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[Display omitted]
•Liposomes containing carborane for Boron Neutron Capture Therapy have been produced.•Liposomes have diameters of 80–100 nm, in the range for crossing the blood-brain-barrier.•Liposomes are stable in serum as reflected by retention experiments.</description><identifier>ISSN: 0301-4622</identifier><identifier>EISSN: 1873-4200</identifier><identifier>DOI: 10.1016/j.bpc.2019.01.003</identifier><identifier>PMID: 30797076</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Blood brain barrier ; BNCT ; Boranes - chemistry ; Boron Neutron Capture Therapy ; Brain tumours ; Cancer ; Carboranes ; Humans ; Liposomes ; Liposomes - chemistry ; Neoplasms - radiotherapy</subject><ispartof>Biophysical chemistry, 2019-04, Vol.247, p.25-33</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-70561cab67f95b26ab2846b3d33567c1c71e650a3be93439e9b09d263a71c26b3</citedby><cites>FETCH-LOGICAL-c462t-70561cab67f95b26ab2846b3d33567c1c71e650a3be93439e9b09d263a71c26b3</cites><orcidid>0000-0002-0137-4595 ; 0000-0001-8805-3788</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0301462218304010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30797076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olusanya, Temidayo O.B.</creatorcontrib><creatorcontrib>Calabrese, Gianpiero</creatorcontrib><creatorcontrib>Fatouros, Dimitrios G.</creatorcontrib><creatorcontrib>Tsibouklis, John</creatorcontrib><creatorcontrib>Smith, James R.</creatorcontrib><title>Liposome formulations of o-carborane for the boron neutron capture therapy of cancer</title><title>Biophysical chemistry</title><addtitle>Biophys Chem</addtitle><description>Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80–100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.
[Display omitted]
•Liposomes containing carborane for Boron Neutron Capture Therapy have been produced.•Liposomes have diameters of 80–100 nm, in the range for crossing the blood-brain-barrier.•Liposomes are stable in serum as reflected by retention experiments.</description><subject>Blood brain barrier</subject><subject>BNCT</subject><subject>Boranes - chemistry</subject><subject>Boron Neutron Capture Therapy</subject><subject>Brain tumours</subject><subject>Cancer</subject><subject>Carboranes</subject><subject>Humans</subject><subject>Liposomes</subject><subject>Liposomes - chemistry</subject><subject>Neoplasms - radiotherapy</subject><issn>0301-4622</issn><issn>1873-4200</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9PwzAMxSMEYmPwAbigHrm0OEmbrOKEJv5Jk7iMc5Skrui0NiVpkfbtSdngiC-W5fee7B8h1xQyClTcbTPT24wBLTOgGQA_IXO6lDzNGcApmQMHmuaCsRm5CGELsZYA52TGQZYSpJiTzbrpXXAtJrXz7bjTQ-O6kLg6canV3jivu59dMnxgEkfXJR2Ow9St7ofR47Txut9PJqs7i_6SnNV6F_Dq2Bfk_elxs3pJ12_Pr6uHdWrjUUMqoRDUaiNkXRaGCW3YMheGV5wXQlpqJUVRgOYGS57zEksDZcUE15JaFoULcnvI7b37HDEMqm2Cxd0u3uzGoBhdFkUh87yIUnqQWu9C8Fir3jet9ntFQU0w1VZFmGqCqYCqCDN6bo7xo2mx-nP80ouC-4MA45NfDXoVbIORQNV4tIOqXPNP_DfV4oRz</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Olusanya, Temidayo O.B.</creator><creator>Calabrese, Gianpiero</creator><creator>Fatouros, Dimitrios G.</creator><creator>Tsibouklis, John</creator><creator>Smith, James R.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0137-4595</orcidid><orcidid>https://orcid.org/0000-0001-8805-3788</orcidid></search><sort><creationdate>201904</creationdate><title>Liposome formulations of o-carborane for the boron neutron capture therapy of cancer</title><author>Olusanya, Temidayo O.B. ; Calabrese, Gianpiero ; Fatouros, Dimitrios G. ; Tsibouklis, John ; Smith, James R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-70561cab67f95b26ab2846b3d33567c1c71e650a3be93439e9b09d263a71c26b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Blood brain barrier</topic><topic>BNCT</topic><topic>Boranes - chemistry</topic><topic>Boron Neutron Capture Therapy</topic><topic>Brain tumours</topic><topic>Cancer</topic><topic>Carboranes</topic><topic>Humans</topic><topic>Liposomes</topic><topic>Liposomes - chemistry</topic><topic>Neoplasms - radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olusanya, Temidayo O.B.</creatorcontrib><creatorcontrib>Calabrese, Gianpiero</creatorcontrib><creatorcontrib>Fatouros, Dimitrios G.</creatorcontrib><creatorcontrib>Tsibouklis, John</creatorcontrib><creatorcontrib>Smith, James R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biophysical chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olusanya, Temidayo O.B.</au><au>Calabrese, Gianpiero</au><au>Fatouros, Dimitrios G.</au><au>Tsibouklis, John</au><au>Smith, James R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liposome formulations of o-carborane for the boron neutron capture therapy of cancer</atitle><jtitle>Biophysical chemistry</jtitle><addtitle>Biophys Chem</addtitle><date>2019-04</date><risdate>2019</risdate><volume>247</volume><spage>25</spage><epage>33</epage><pages>25-33</pages><issn>0301-4622</issn><eissn>1873-4200</eissn><abstract>Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80–100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.
[Display omitted]
•Liposomes containing carborane for Boron Neutron Capture Therapy have been produced.•Liposomes have diameters of 80–100 nm, in the range for crossing the blood-brain-barrier.•Liposomes are stable in serum as reflected by retention experiments.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30797076</pmid><doi>10.1016/j.bpc.2019.01.003</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0137-4595</orcidid><orcidid>https://orcid.org/0000-0001-8805-3788</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-4622 |
| ispartof | Biophysical chemistry, 2019-04, Vol.247, p.25-33 |
| issn | 0301-4622 1873-4200 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Blood brain barrier BNCT Boranes - chemistry Boron Neutron Capture Therapy Brain tumours Cancer Carboranes Humans Liposomes Liposomes - chemistry Neoplasms - radiotherapy |
| title | Liposome formulations of o-carborane for the boron neutron capture therapy of cancer |
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