Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg–DNA Interaction

The interaction of the regulatory biologically active peptide Glu-Asp-Arg (EDR) with DNA is considered by spectral, NMR, viscosimetry, and molecular dynamics methods. It was shown that EDR can partly penetrate into the major groove of DNA and affect the base atoms, mainly the N7 and O6 of guanine. I...

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Veröffentlicht in:The journal of physical chemistry. B 2019-03, Vol.123 (9), p.1896-1902
Hauptverfasser: Silanteva, Irina A, Komolkin, Andrei V, Morozova, Ekaterina A, Vorontsov-Velyaminov, Pavel N, Kasyanenko, Nina A
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container_end_page 1902
container_issue 9
container_start_page 1896
container_title The journal of physical chemistry. B
container_volume 123
creator Silanteva, Irina A
Komolkin, Andrei V
Morozova, Ekaterina A
Vorontsov-Velyaminov, Pavel N
Kasyanenko, Nina A
description The interaction of the regulatory biologically active peptide Glu-Asp-Arg (EDR) with DNA is considered by spectral, NMR, viscosimetry, and molecular dynamics methods. It was shown that EDR can partly penetrate into the major groove of DNA and affect the base atoms, mainly the N7 and O6 of guanine. It was observed that Mg2+ ions can promote DNA–EDR interaction due to their effective screening of the negatively charged phosphate groups of DNA. This action of Mg2+ remains in salted solution as well.
doi_str_mv 10.1021/acs.jpcb.8b10359
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title Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg–DNA Interaction
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