KCNQ1OT1/miR-217/ZEB1 feedback loop facilitates cell migration and epithelial-mesenchymal transition in colorectal cancer

Long noncoding RNAs are widely acknowledged as a group of regulatory factors in various diseases, especially in cancers. KCNQ1 overlapping transcript 1 (KCNQ1OT1) has been reported as oncogene in human cancers. However, the role of KCNQ1OT1 in colorectal cancer (CRC) has not been fully explained. Ba...

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Veröffentlicht in:	Cancer biology & therapy 2019-06, Vol.20 (6), p.886-896
Hauptverfasser:	Bian, Yinzhu, Gao, Guangyi, Zhang, Qun, Qian, Hanqing, Yu, Lixia, Yao, Ninghua, Qian, Jing, Liu, Baorui, Qian, Xiaoping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation, Neoplastic Humans KCNQ1OT1 Mice, Knockout MicroRNAs - genetics migration miR-217 Potassium Channels, Voltage-Gated - genetics Prognosis Research Paper RNA Interference Transcription, Genetic ZEB1 Zinc Finger E-box-Binding Homeobox 1 - genetics Zinc Finger E-box-Binding Homeobox 1 - metabolism
Online-Zugang:	Volltext
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