Analgesic Activity of Hexaazaisowurtzitane Derivatives
Pronounced analgesic activity of the innovative compound 4-(3,4-dibromthiophencarbonyl)-2,6,8,12-tetraacethyl-2,4,6,8,10,12hexaazatetracyclo[5,5,0,0 3, 11 ,0 5, 9 ] dodecane (thiowurtzine) was observed in the thermal nociceptive hot plate test and in the acute visceral and somatic deep pain model (a...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2019-02, Vol.166 (4), p.461-465 |
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| creator | Krylova, S. G. Povet’eva, T. N. Zueva, E. P. Suslov, N. I. Amosova, E. N. Razina, T. G. Lopatina, K. A. Rybalkina, O. Yu Nesterova, Yu. V. Afanas’eva, O. G. Kiseleva, E. A. Sysolyatin, S. V. Kulagina, D. A. Zhdanov, V. V. |
| description | Pronounced analgesic activity of the innovative compound 4-(3,4-dibromthiophencarbonyl)-2,6,8,12-tetraacethyl-2,4,6,8,10,12hexaazatetracyclo[5,5,0,0
3, 11
,0
5, 9
] dodecane (thiowurtzine) was observed in the thermal nociceptive hot plate test and in the acute visceral and somatic deep pain model (acetic acid writhing test). In these experimental models, naloxone-sensitive thiowurtzine-induced analgesia was revealed. The absence of tropism to peripheral opioid receptors in the acetic acid writhing test was demonstrated using naloxone methiodide. Course administration of low-toxic thiowurtzine in effective doses was not associated with ulcerogenic damage to the gastric mucosa in experimental animals. |
| doi_str_mv | 10.1007/s10517-019-04372-9 |
| format | Article |
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3, 11
,0
5, 9
] dodecane (thiowurtzine) was observed in the thermal nociceptive hot plate test and in the acute visceral and somatic deep pain model (acetic acid writhing test). In these experimental models, naloxone-sensitive thiowurtzine-induced analgesia was revealed. The absence of tropism to peripheral opioid receptors in the acetic acid writhing test was demonstrated using naloxone methiodide. Course administration of low-toxic thiowurtzine in effective doses was not associated with ulcerogenic damage to the gastric mucosa in experimental animals.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-019-04372-9</identifier><identifier>PMID: 30788739</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acetic acid ; Analgesia ; Analgesics ; Analgesics - therapeutic use ; Animals ; Anti-inflammatory agents ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Chronic pain ; Disease Models, Animal ; Dodecane ; Gastric mucosa ; Gastric Mucosa - drug effects ; Internal Medicine ; Laboratory Medicine ; Male ; Mice ; Naloxone ; Naloxone - therapeutic use ; Opioid receptors ; Organic acids ; Pain - drug therapy ; Pain - physiopathology ; Pain management ; Pain Measurement - methods ; Pain perception ; Pathology ; Psychology ; Resveratrol ; Steroidal anti-inflammatory agents ; Tropism</subject><ispartof>Bulletin of experimental biology and medicine, 2019-02, Vol.166 (4), p.461-465</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-4bb5302ebc44b6a88d2d2968948a63b23a88d30d9c8ffb36abfafef1c69d2e7b3</citedby><cites>FETCH-LOGICAL-c473t-4bb5302ebc44b6a88d2d2968948a63b23a88d30d9c8ffb36abfafef1c69d2e7b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-019-04372-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-019-04372-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30788739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krylova, S. G.</creatorcontrib><creatorcontrib>Povet’eva, T. N.</creatorcontrib><creatorcontrib>Zueva, E. P.</creatorcontrib><creatorcontrib>Suslov, N. I.</creatorcontrib><creatorcontrib>Amosova, E. N.</creatorcontrib><creatorcontrib>Razina, T. G.</creatorcontrib><creatorcontrib>Lopatina, K. A.</creatorcontrib><creatorcontrib>Rybalkina, O. Yu</creatorcontrib><creatorcontrib>Nesterova, Yu. V.</creatorcontrib><creatorcontrib>Afanas’eva, O. G.</creatorcontrib><creatorcontrib>Kiseleva, E. A.</creatorcontrib><creatorcontrib>Sysolyatin, S. V.</creatorcontrib><creatorcontrib>Kulagina, D. A.</creatorcontrib><creatorcontrib>Zhdanov, V. V.</creatorcontrib><title>Analgesic Activity of Hexaazaisowurtzitane Derivatives</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Pronounced analgesic activity of the innovative compound 4-(3,4-dibromthiophencarbonyl)-2,6,8,12-tetraacethyl-2,4,6,8,10,12hexaazatetracyclo[5,5,0,0
3, 11
,0
5, 9
] dodecane (thiowurtzine) was observed in the thermal nociceptive hot plate test and in the acute visceral and somatic deep pain model (acetic acid writhing test). In these experimental models, naloxone-sensitive thiowurtzine-induced analgesia was revealed. The absence of tropism to peripheral opioid receptors in the acetic acid writhing test was demonstrated using naloxone methiodide. Course administration of low-toxic thiowurtzine in effective doses was not associated with ulcerogenic damage to the gastric mucosa in experimental animals.</description><subject>Acetic acid</subject><subject>Analgesia</subject><subject>Analgesics</subject><subject>Analgesics - therapeutic use</subject><subject>Animals</subject><subject>Anti-inflammatory agents</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Chronic pain</subject><subject>Disease Models, Animal</subject><subject>Dodecane</subject><subject>Gastric mucosa</subject><subject>Gastric Mucosa - drug effects</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Mice</subject><subject>Naloxone</subject><subject>Naloxone - therapeutic use</subject><subject>Opioid receptors</subject><subject>Organic acids</subject><subject>Pain - drug therapy</subject><subject>Pain - physiopathology</subject><subject>Pain management</subject><subject>Pain Measurement - methods</subject><subject>Pain perception</subject><subject>Pathology</subject><subject>Psychology</subject><subject>Resveratrol</subject><subject>Steroidal anti-inflammatory agents</subject><subject>Tropism</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kV1LHDEYhUNpqevHH_BCFoTizWi-ZpJcLvbDguCNXock82aNzE5sktHqr2_WtbUWKbkIefOcw3s4CO0TfEwwFieZ4JaIBhPVYM4EbdQ7NCOtYI2klLxHM1yphkspt9B2zjfrJ-7IR7TFsJBSMDVD3WI0wxJycPOFK-EulId59PMz-GnMowk53k-pPIZiRph_hhTuTIUg76IP3gwZ9p7vHXT19cvl6VlzfvHt--nivHFcsNJwa1uGKVjHue2MlD3tqeqk4tJ0zFK2HjHcKye9t6wz1hsPnrhO9RSEZTvoaON7m-KPCXLRq5AdDEPdJ05ZUyJ5y5QivKKH_6A3cUo13RPFFO2wbF-opRlAh9HHkoxbm-pFqzgjElNRqeM3qHp6WAUXR_Chzl8JPv0luAYzlOsch6mEOObXIN2ALsWcE3h9m8LKpAdNsF63qjet6tqqfmpVqyo6eI422RX0fyS_a6wA2wC5fo1LSC_Z_2P7CxlZqlg</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Krylova, S. G.</creator><creator>Povet’eva, T. N.</creator><creator>Zueva, E. P.</creator><creator>Suslov, N. I.</creator><creator>Amosova, E. N.</creator><creator>Razina, T. G.</creator><creator>Lopatina, K. A.</creator><creator>Rybalkina, O. Yu</creator><creator>Nesterova, Yu. V.</creator><creator>Afanas’eva, O. G.</creator><creator>Kiseleva, E. A.</creator><creator>Sysolyatin, S. V.</creator><creator>Kulagina, D. A.</creator><creator>Zhdanov, V. 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G. ; Povet’eva, T. N. ; Zueva, E. P. ; Suslov, N. I. ; Amosova, E. N. ; Razina, T. G. ; Lopatina, K. A. ; Rybalkina, O. Yu ; Nesterova, Yu. V. ; Afanas’eva, O. G. ; Kiseleva, E. A. ; Sysolyatin, S. V. ; Kulagina, D. A. ; Zhdanov, V. 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G.</au><au>Povet’eva, T. N.</au><au>Zueva, E. P.</au><au>Suslov, N. I.</au><au>Amosova, E. N.</au><au>Razina, T. G.</au><au>Lopatina, K. A.</au><au>Rybalkina, O. Yu</au><au>Nesterova, Yu. V.</au><au>Afanas’eva, O. G.</au><au>Kiseleva, E. A.</au><au>Sysolyatin, S. V.</au><au>Kulagina, D. A.</au><au>Zhdanov, V. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analgesic Activity of Hexaazaisowurtzitane Derivatives</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>166</volume><issue>4</issue><spage>461</spage><epage>465</epage><pages>461-465</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>Pronounced analgesic activity of the innovative compound 4-(3,4-dibromthiophencarbonyl)-2,6,8,12-tetraacethyl-2,4,6,8,10,12hexaazatetracyclo[5,5,0,0
3, 11
,0
5, 9
] dodecane (thiowurtzine) was observed in the thermal nociceptive hot plate test and in the acute visceral and somatic deep pain model (acetic acid writhing test). In these experimental models, naloxone-sensitive thiowurtzine-induced analgesia was revealed. The absence of tropism to peripheral opioid receptors in the acetic acid writhing test was demonstrated using naloxone methiodide. Course administration of low-toxic thiowurtzine in effective doses was not associated with ulcerogenic damage to the gastric mucosa in experimental animals.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30788739</pmid><doi>10.1007/s10517-019-04372-9</doi><tpages>5</tpages></addata></record> |
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| subjects | Acetic acid Analgesia Analgesics Analgesics - therapeutic use Animals Anti-inflammatory agents Biomedical and Life Sciences Biomedicine Cell Biology Chronic pain Disease Models, Animal Dodecane Gastric mucosa Gastric Mucosa - drug effects Internal Medicine Laboratory Medicine Male Mice Naloxone Naloxone - therapeutic use Opioid receptors Organic acids Pain - drug therapy Pain - physiopathology Pain management Pain Measurement - methods Pain perception Pathology Psychology Resveratrol Steroidal anti-inflammatory agents Tropism |
| title | Analgesic Activity of Hexaazaisowurtzitane Derivatives |
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