Gene-environment interaction impacts on heart development and embryo survival

Congenital heart disease (CHD) is the most common type of birth defect. In recent years, research has focussed on identifying the genetic causes of CHD. However, only a minority of CHD cases can be attributed to single gene mutations. In addition, studies have identified different environmental stre...

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Veröffentlicht in:	Development (Cambridge) 2019-02, Vol.146 (4)
Hauptverfasser:	Moreau, Julie L M, Kesteven, Scott, Martin, Ella M M A, Lau, Kin S, Yam, Michelle X, O'Reilly, Victoria C, Del Monte-Nieto, Gonzalo, Baldini, Antonio, Feneley, Michael P, Moon, Anne M, Harvey, Richard P, Sparrow, Duncan B, Chapman, Gavin, Dunwoodie, Sally L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Proliferation Embryo, Mammalian - metabolism Female Gene-Environment Interaction Genetic Predisposition to Disease Heart - diagnostic imaging Heart - embryology Heart Defects, Congenital - genetics Heterozygote Homeobox Protein Nkx-2.5 - genetics Homeobox Protein Nkx-2.5 - physiology Homeodomain Proteins - genetics Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - physiology Male Mice Mice, Inbred C57BL Mice, Transgenic Oxygen - metabolism Receptor, Fibroblast Growth Factor, Type 1 - genetics T-Box Domain Proteins - genetics Time Factors
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