Urinary neutrophil gelatinase-associated lipocalin for diagnosis of spontaneous bacterial peritonitis

Urinary neutrophil gelatinase-associated lipocalin for diagnosis of spontaneous bacterial peritonitis

Cirrhotic patients with ascites are at high risk of developing spontaneous bacterial peritonitis (SBP). After exclusion of patients with acute kidney injury (AKI) or other infections, urinary neutrophil gelatinase-associated lipocalin (NGAL) levels were compared between two matched groups of Egyptia...

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Veröffentlicht in:Tropical doctor 2019-07, Vol.49 (3), p.189-192
Hauptverfasser: Fouad, Tamer R, Abdelsameea, Eman, Elsabaawy, Maha, Ashraf Eljaky, M., Zaki El-shenawy, Soha, Omar, Nabil
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container_end_page 192
container_issue 3
container_start_page 189
container_title Tropical doctor
container_volume 49
creator Fouad, Tamer R
Abdelsameea, Eman
Elsabaawy, Maha
Ashraf Eljaky, M.
Zaki El-shenawy, Soha
Omar, Nabil
description Cirrhotic patients with ascites are at high risk of developing spontaneous bacterial peritonitis (SBP). After exclusion of patients with acute kidney injury (AKI) or other infections, urinary neutrophil gelatinase-associated lipocalin (NGAL) levels were compared between two matched groups of Egyptian cirrhotic patients with ascites, mostly secondary to hepatitis C infection (98%). Group 1 had SBP (n = 41) and group 2 did not (n = 45). By univariate analysis, urinary-NGAL, high total bilirubin, serum creatinine, international normalised ratio and the Model of End-Stage Liver Disease (MELD) score and low platelet count were all significantly correlated with the presence of SBP, but only urinary-NGAL could independently predict development of SBP (P = 0.001). Urinary-NGAL at a cut-off value of 1225 pg/mL, showed a sensitivity of 95% and a specificity of 76%, and is therefore a most useful tool.
doi_str_mv 10.1177/0049475519830265
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title Urinary neutrophil gelatinase-associated lipocalin for diagnosis of spontaneous bacterial peritonitis
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