β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration

The grey matter is a central target of pathological processes in neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases. The grey matter is often also affected in multiple sclerosis, an autoimmune disease of the central nervous system. The mechanisms that underlie grey matter infla...

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Veröffentlicht in:	Nature (London) 2019-02, Vol.566 (7745), p.503-508
Hauptverfasser:	Lodygin, Dmitri, Hermann, Moritz, Schweingruber, Nils, Flügel-Koch, Cassandra, Watanabe, Takashi, Schlosser, Corinna, Merlini, Arianna, Körner, Henrike, Chang, Hsin-Fang, Fischer, Henrike J., Reichardt, Holger M., Zagrebelsky, Marta, Mollenhauer, Brit, Kügler, Sebastian, Fitzner, Dirk, Frahm, Jens, Stadelmann, Christine, Haberl, Michael, Odoardi, Francesca, Flügel, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/31 13/51 14 14/19 14/28 14/63 14/69 38 38/91 42 42/44 45/41 59 59/57 631/250 631/250/371 64 82 Alzheimer's disease Animals Atrophy Autoimmune diseases beta-Synuclein - analysis beta-Synuclein - genetics beta-Synuclein - immunology beta-Synuclein - metabolism Brain Brain - pathology Cell activation Cell Movement - immunology Central nervous system Degeneration Disease Female Gene expression Gene Expression Regulation Gliosis Gliosis - pathology Gray Matter - immunology Gray Matter - pathology Humanities and Social Sciences Humans Immune system Inflammation Inflammation - immunology Inflammation - pathology Lymphocyte Activation Lymphocyte Count Lymphocytes Lymphocytes T Male Movement disorders multidisciplinary Multiple sclerosis Multiple Sclerosis, Chronic Progressive - blood Multiple Sclerosis, Chronic Progressive - immunology Multiple Sclerosis, Chronic Progressive - pathology Nervous system Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - immunology Neurodegenerative Diseases - pathology Neurons - pathology Parkinson's disease Pathology Priming Proteins Rats Rats, Inbred Lew Science Science (multidisciplinary) Spinal cord Substantia grisea Synuclein T cell receptors T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology
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