Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes

Background: Intracellular uric acid is known to increase the protein level and channel current of atrial Kv1.5; however, mechanisms of the uric acid-induced enhancement of Kv1.5 expression remain unclear. Methods and Results: The effects of uric acid on mRNA and protein levels of Kv1.5, as well as t...

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Veröffentlicht in:	Circulation Journal 2019/03/25, Vol.83(4), pp.718-726
Hauptverfasser:	Taufiq, Fikri, Maharani, Nani, Li, Peili, Kurata, Yasutaka, Ikeda, Nobuhito, Kuwabara, Masanari, Otani, Naoyuki, Miake, Junichiro, Hasegawa, Akira, Tsuneto, Motokazu, Shirayoshi, Yasuaki, Ninomiya, Haruaki, Saitoh, Tatsuya, Nakai, Akira, Yamamoto, Kazuhiro, Hisatome, Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Animals Cell Line Heat shock factor 1 Heat shock protein 70 Heat Shock Transcription Factors - metabolism HSP70 Heat-Shock Proteins - metabolism Kv1.5 Kv1.5 Potassium Channel - drug effects Kv1.5 Potassium Channel - metabolism Mice Myocytes, Cardiac - metabolism Phosphorylation - drug effects Protein Biosynthesis Proto-Oncogene Proteins c-akt - metabolism Transcription, Genetic Uric acid Uric Acid - pharmacology
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