Novel 2,4-disubstituted quinazolines as cytotoxic agents and JAK2 inhibitors: Synthesis, in vitro evaluation and molecular dynamics studies

[Display omitted] •Present investigation focused on identification of novel quinazolines for cytotoxic and JAK2 inhibitory activities.•Considerable In vitro cytotoxic potentials were reported against selected human (and non-human) cancer cell lines.•In vitro JAK2 inhibition studies elucidated the me...

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Veröffentlicht in:	Computational biology and chemistry 2019-04, Vol.79, p.110-118
Hauptverfasser:	Jyothi Buggana, Siva, Paturi, Mani Chandrika, Perka, Harathi, Gade, Deepak Reddy, VVS, Rajendra Prasad
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Breast cancer Cell Line, Tumor Cell Proliferation - drug effects Cytotoxic activity Cytotoxins - chemical synthesis Cytotoxins - chemistry Cytotoxins - pharmacology Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans JAK2 Janus Kinase 2 - antagonists & inhibitors Janus Kinase 2 - metabolism Molecular dynamics Molecular Dynamics Simulation Molecular Structure MTT assay Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Quinazoline Quinazolines - chemical synthesis Quinazolines - chemistry Quinazolines - pharmacology Structure-Activity Relationship
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