Zika Virus Infects Newborn Monocytes Without Triggering a Substantial Cytokine Response

Zika virus (ZIKV) is a clinically important flavivirus that can cause neurological disturbances in newborns. Here, we investigated comparatively the outcome of in vitro infection of newborn monocytes by ZIKV. We observed that neonatal cells show defective production of interleukin 1β, interleukin 10...

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Veröffentlicht in:	The Journal of infectious diseases 2019-06, Vol.220 (1), p.32-40
Hauptverfasser:	Yoshikawa, Fabio Seiti Yamada, Pietrobon, Anna Julia, Branco, Anna Cláudia Calvielli Castelo, Pereira, Nátalli Zanete, da Silva Oliveira, Luanda Mara, Machado, Clarisse Martins, da Silva Duarte, Alberto José, Sato, Maria Notomi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured CLEC5A protein Cytokines Cytokines - immunology Humans Immune response Infant, Newborn Infectivity Interleukin 10 Lectins, C-Type - immunology Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - virology Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Monocytes - immunology Monocytes - virology Neonates Neurological complications Newborn babies Receptors, Cell Surface - immunology Viral infections Viral Load - immunology VIRUSES Zika virus Zika Virus - immunology Zika Virus Infection - immunology Zika Virus Infection - virology
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