Anti-enteroviral activity of new MDL-860 analogues: Synthesis, in vitro/in vivo studies and QSAR analysis

[Display omitted] •60 analogues of antiviral agent MDL-860 were obtained and 6 diaryl ethers demonstrated high in vitro antiviral activity (SI > 50) against enteroviruses CVB1, CVB3 and PV1.•The most active compounds are low toxic.•QSAR analysis was performed.•X-ray crystallography for one of the...

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Veröffentlicht in:	Bioorganic chemistry 2019-04, Vol.85, p.487-497
Hauptverfasser:	Nikolova, Ivanka, Slavchev, Ivaylo, Ravutsov, Martin, Dangalov, Miroslav, Nikolova, Yana, Zagranyarska, Irena, Stoyanova, Adelina, Nikolova, Nadya, Mukova, Lucia, Grozdanov, Petar, Nikolova, Rosica, Shivachev, Boris, Kuz'min, Victor E., Ognichenko, Liudmila N., Galabov, Angel S., Dobrikov, Georgi M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-enteroviral Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Cell Line Coxsackieviruses Crystallography, X-Ray Humans MDL-860 Microbial Sensitivity Tests Molecular Structure Nitriles - chemical synthesis Nitriles - chemistry Nitriles - pharmacology Nitrobenzonitriles Poliovirus - drug effects QSAR Quantitative Structure-Activity Relationship Synthesis
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