Association of epicardial adipose tissue attenuation with coronary atherosclerosis in patients with a high risk of coronary artery disease
Density may indicate some tissue characteristics and help reveal the role of epicardial adipose tissue (EAT) in coronary artery disease (CAD). Therefore, we assessed the association of EAT density with the coronary artery plaque burden in patients presenting with chest pain. This retrospective cohor...
Gespeichert in:
| Veröffentlicht in: | Atherosclerosis 2019-05, Vol.284, p.230-236 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 236 |
|---|---|
| container_issue | |
| container_start_page | 230 |
| container_title | Atherosclerosis |
| container_volume | 284 |
| creator | Liu, Zihou Wang, Shunjun Wang, Yongqiang Zhou, Ningbo Shu, Jie Stamm, Christof Jiang, Meng Luo, Fanyan |
| description | Density may indicate some tissue characteristics and help reveal the role of epicardial adipose tissue (EAT) in coronary artery disease (CAD). Therefore, we assessed the association of EAT density with the coronary artery plaque burden in patients presenting with chest pain.
This retrospective cohort study comprised 614 patients (mean age 61 ± 9 years, 61% males) with a high cardiovascular disease risk, who underwent cardiac computed tomography angiography. Density was reflected as attenuation.
EAT attenuation was significantly associated with EAT volume with a negative Pearson's correlation coefficient and gradually increased across coronary artery calcium (CAC) scores of 0, 1–100, 101–400 and > 400. EAT attenuation was tightly associated with CAD risk factors, including age, sex, BMI, total cholesterol, neutrophil to lymphocyte ratios and CAC score. The association between EAT attenuation and CAC score was strengthened after adjusting for multivariable indices (OR 1.21, 95% CI 1.05–1.40, p = 0.01) and further adjusting for EAT volume (OR 1.26 95% CI 1.06–1.51, p |
| doi_str_mv | 10.1016/j.atherosclerosis.2019.01.033 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2183647341</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0021915019300577</els_id><sourcerecordid>2183647341</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-921ebebe494e736cfba60743676cdf30c662a395193044358738eae4bf5d65753</originalsourceid><addsrcrecordid>eNqNkcFu1DAQhi0EokvhFZAvSFwS7NixkwOHqioFqRIXOFteZ8LOko2DxwHxCjw1XqWA1BOyNHP5xv_88zP2SopaCmneHGufD5AihelckepGyL4WshZKPWI72dm-krrTj9lOiEZWvWzFBXtGdBRCaCu7p-xCCWutUt2O_boiigF9xjjzOHJYMPg0oJ-4H3CJBDwj0Qrc5wzzuoE_MB94iCnOPv3kDxbiOPOlcDBn2kjPD_jlwBPS17PGv8GUobQBCTzBc_Zk9BPBi_t-yT6_u_l0_b66-3j74frqrgqq63PVNxL25eleg1UmjHtvhNXKWBOGUYlgTONV38peCa1V21nVgQe9H9vBtLZVl-z19u-S4rcVKLsTUoBp8jPElVwjO2W0VVoW9O2GhuKMEoxuSXgqqzsp3DkOd3QP3LtzHE5IV-Io8y_vpdb9CYa_03_uX4DbDYBi-DtCchTK4QIMmCBkN0T8T6nfN5-paQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2183647341</pqid></control><display><type>article</type><title>Association of epicardial adipose tissue attenuation with coronary atherosclerosis in patients with a high risk of coronary artery disease</title><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Liu, Zihou ; Wang, Shunjun ; Wang, Yongqiang ; Zhou, Ningbo ; Shu, Jie ; Stamm, Christof ; Jiang, Meng ; Luo, Fanyan</creator><creatorcontrib>Liu, Zihou ; Wang, Shunjun ; Wang, Yongqiang ; Zhou, Ningbo ; Shu, Jie ; Stamm, Christof ; Jiang, Meng ; Luo, Fanyan</creatorcontrib><description>Density may indicate some tissue characteristics and help reveal the role of epicardial adipose tissue (EAT) in coronary artery disease (CAD). Therefore, we assessed the association of EAT density with the coronary artery plaque burden in patients presenting with chest pain.
This retrospective cohort study comprised 614 patients (mean age 61 ± 9 years, 61% males) with a high cardiovascular disease risk, who underwent cardiac computed tomography angiography. Density was reflected as attenuation.
EAT attenuation was significantly associated with EAT volume with a negative Pearson's correlation coefficient and gradually increased across coronary artery calcium (CAC) scores of 0, 1–100, 101–400 and > 400. EAT attenuation was tightly associated with CAD risk factors, including age, sex, BMI, total cholesterol, neutrophil to lymphocyte ratios and CAC score. The association between EAT attenuation and CAC score was strengthened after adjusting for multivariable indices (OR 1.21, 95% CI 1.05–1.40, p = 0.01) and further adjusting for EAT volume (OR 1.26 95% CI 1.06–1.51, p<0.01). However, EAT attenuation was associated only with CAD presence (OR 1.32, 95% CI 1.02–1.69, p<0.05), CAC presence (OR 1.28, 95% CI 1.02–1.60, p<0.05), segment involvement score (OR 1.19, 95% CI 1.01–1.40, p<0.05) and segment stenosis score (OR 1.19, 95% CI 1.01–1.40, p<0.05) in the EAT volume- and multivariable-adjusted model. Additionally, EAT attenuation was not associated with significant coronary artery lesions and triple-vessel plaques.
Higher EAT attenuation is associated with a higher risk of CAD.
[Display omitted]
•Epicardial adipose tissue (EAT) attenuation and volume significantly correlated, but this relationship gradually diminished with increasing CAC scores•EAT attenuation was associated with CAD risk factors and the presence of CAD and CAC.•EAT attenuation was not associated with the presence of significant coronary lesions and triple-vessel plaques.•EAT attenuation was associated with CAC score, SIS and SSS.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2019.01.033</identifier><identifier>PMID: 30777338</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Attenuation ; Coronary artery disease ; Epicardial adipose tissue ; Tissue volume</subject><ispartof>Atherosclerosis, 2019-05, Vol.284, p.230-236</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-921ebebe494e736cfba60743676cdf30c662a395193044358738eae4bf5d65753</citedby><cites>FETCH-LOGICAL-c389t-921ebebe494e736cfba60743676cdf30c662a395193044358738eae4bf5d65753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021915019300577$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30777338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Zihou</creatorcontrib><creatorcontrib>Wang, Shunjun</creatorcontrib><creatorcontrib>Wang, Yongqiang</creatorcontrib><creatorcontrib>Zhou, Ningbo</creatorcontrib><creatorcontrib>Shu, Jie</creatorcontrib><creatorcontrib>Stamm, Christof</creatorcontrib><creatorcontrib>Jiang, Meng</creatorcontrib><creatorcontrib>Luo, Fanyan</creatorcontrib><title>Association of epicardial adipose tissue attenuation with coronary atherosclerosis in patients with a high risk of coronary artery disease</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Density may indicate some tissue characteristics and help reveal the role of epicardial adipose tissue (EAT) in coronary artery disease (CAD). Therefore, we assessed the association of EAT density with the coronary artery plaque burden in patients presenting with chest pain.
This retrospective cohort study comprised 614 patients (mean age 61 ± 9 years, 61% males) with a high cardiovascular disease risk, who underwent cardiac computed tomography angiography. Density was reflected as attenuation.
EAT attenuation was significantly associated with EAT volume with a negative Pearson's correlation coefficient and gradually increased across coronary artery calcium (CAC) scores of 0, 1–100, 101–400 and > 400. EAT attenuation was tightly associated with CAD risk factors, including age, sex, BMI, total cholesterol, neutrophil to lymphocyte ratios and CAC score. The association between EAT attenuation and CAC score was strengthened after adjusting for multivariable indices (OR 1.21, 95% CI 1.05–1.40, p = 0.01) and further adjusting for EAT volume (OR 1.26 95% CI 1.06–1.51, p<0.01). However, EAT attenuation was associated only with CAD presence (OR 1.32, 95% CI 1.02–1.69, p<0.05), CAC presence (OR 1.28, 95% CI 1.02–1.60, p<0.05), segment involvement score (OR 1.19, 95% CI 1.01–1.40, p<0.05) and segment stenosis score (OR 1.19, 95% CI 1.01–1.40, p<0.05) in the EAT volume- and multivariable-adjusted model. Additionally, EAT attenuation was not associated with significant coronary artery lesions and triple-vessel plaques.
Higher EAT attenuation is associated with a higher risk of CAD.
[Display omitted]
•Epicardial adipose tissue (EAT) attenuation and volume significantly correlated, but this relationship gradually diminished with increasing CAC scores•EAT attenuation was associated with CAD risk factors and the presence of CAD and CAC.•EAT attenuation was not associated with the presence of significant coronary lesions and triple-vessel plaques.•EAT attenuation was associated with CAC score, SIS and SSS.</description><subject>Attenuation</subject><subject>Coronary artery disease</subject><subject>Epicardial adipose tissue</subject><subject>Tissue volume</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqNkcFu1DAQhi0EokvhFZAvSFwS7NixkwOHqioFqRIXOFteZ8LOko2DxwHxCjw1XqWA1BOyNHP5xv_88zP2SopaCmneHGufD5AihelckepGyL4WshZKPWI72dm-krrTj9lOiEZWvWzFBXtGdBRCaCu7p-xCCWutUt2O_boiigF9xjjzOHJYMPg0oJ-4H3CJBDwj0Qrc5wzzuoE_MB94iCnOPv3kDxbiOPOlcDBn2kjPD_jlwBPS17PGv8GUobQBCTzBc_Zk9BPBi_t-yT6_u_l0_b66-3j74frqrgqq63PVNxL25eleg1UmjHtvhNXKWBOGUYlgTONV38peCa1V21nVgQe9H9vBtLZVl-z19u-S4rcVKLsTUoBp8jPElVwjO2W0VVoW9O2GhuKMEoxuSXgqqzsp3DkOd3QP3LtzHE5IV-Io8y_vpdb9CYa_03_uX4DbDYBi-DtCchTK4QIMmCBkN0T8T6nfN5-paQ</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Liu, Zihou</creator><creator>Wang, Shunjun</creator><creator>Wang, Yongqiang</creator><creator>Zhou, Ningbo</creator><creator>Shu, Jie</creator><creator>Stamm, Christof</creator><creator>Jiang, Meng</creator><creator>Luo, Fanyan</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201905</creationdate><title>Association of epicardial adipose tissue attenuation with coronary atherosclerosis in patients with a high risk of coronary artery disease</title><author>Liu, Zihou ; Wang, Shunjun ; Wang, Yongqiang ; Zhou, Ningbo ; Shu, Jie ; Stamm, Christof ; Jiang, Meng ; Luo, Fanyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-921ebebe494e736cfba60743676cdf30c662a395193044358738eae4bf5d65753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Attenuation</topic><topic>Coronary artery disease</topic><topic>Epicardial adipose tissue</topic><topic>Tissue volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Zihou</creatorcontrib><creatorcontrib>Wang, Shunjun</creatorcontrib><creatorcontrib>Wang, Yongqiang</creatorcontrib><creatorcontrib>Zhou, Ningbo</creatorcontrib><creatorcontrib>Shu, Jie</creatorcontrib><creatorcontrib>Stamm, Christof</creatorcontrib><creatorcontrib>Jiang, Meng</creatorcontrib><creatorcontrib>Luo, Fanyan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Zihou</au><au>Wang, Shunjun</au><au>Wang, Yongqiang</au><au>Zhou, Ningbo</au><au>Shu, Jie</au><au>Stamm, Christof</au><au>Jiang, Meng</au><au>Luo, Fanyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of epicardial adipose tissue attenuation with coronary atherosclerosis in patients with a high risk of coronary artery disease</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2019-05</date><risdate>2019</risdate><volume>284</volume><spage>230</spage><epage>236</epage><pages>230-236</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Density may indicate some tissue characteristics and help reveal the role of epicardial adipose tissue (EAT) in coronary artery disease (CAD). Therefore, we assessed the association of EAT density with the coronary artery plaque burden in patients presenting with chest pain.
This retrospective cohort study comprised 614 patients (mean age 61 ± 9 years, 61% males) with a high cardiovascular disease risk, who underwent cardiac computed tomography angiography. Density was reflected as attenuation.
EAT attenuation was significantly associated with EAT volume with a negative Pearson's correlation coefficient and gradually increased across coronary artery calcium (CAC) scores of 0, 1–100, 101–400 and > 400. EAT attenuation was tightly associated with CAD risk factors, including age, sex, BMI, total cholesterol, neutrophil to lymphocyte ratios and CAC score. The association between EAT attenuation and CAC score was strengthened after adjusting for multivariable indices (OR 1.21, 95% CI 1.05–1.40, p = 0.01) and further adjusting for EAT volume (OR 1.26 95% CI 1.06–1.51, p<0.01). However, EAT attenuation was associated only with CAD presence (OR 1.32, 95% CI 1.02–1.69, p<0.05), CAC presence (OR 1.28, 95% CI 1.02–1.60, p<0.05), segment involvement score (OR 1.19, 95% CI 1.01–1.40, p<0.05) and segment stenosis score (OR 1.19, 95% CI 1.01–1.40, p<0.05) in the EAT volume- and multivariable-adjusted model. Additionally, EAT attenuation was not associated with significant coronary artery lesions and triple-vessel plaques.
Higher EAT attenuation is associated with a higher risk of CAD.
[Display omitted]
•Epicardial adipose tissue (EAT) attenuation and volume significantly correlated, but this relationship gradually diminished with increasing CAC scores•EAT attenuation was associated with CAD risk factors and the presence of CAD and CAC.•EAT attenuation was not associated with the presence of significant coronary lesions and triple-vessel plaques.•EAT attenuation was associated with CAC score, SIS and SSS.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>30777338</pmid><doi>10.1016/j.atherosclerosis.2019.01.033</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9150 |
| ispartof | Atherosclerosis, 2019-05, Vol.284, p.230-236 |
| issn | 0021-9150 1879-1484 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2183647341 |
| source | Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Attenuation Coronary artery disease Epicardial adipose tissue Tissue volume |
| title | Association of epicardial adipose tissue attenuation with coronary atherosclerosis in patients with a high risk of coronary artery disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T23%3A57%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20epicardial%20adipose%20tissue%20attenuation%20with%20coronary%20atherosclerosis%20in%20patients%20with%20a%20high%20risk%20of%20coronary%20artery%20disease&rft.jtitle=Atherosclerosis&rft.au=Liu,%20Zihou&rft.date=2019-05&rft.volume=284&rft.spage=230&rft.epage=236&rft.pages=230-236&rft.issn=0021-9150&rft.eissn=1879-1484&rft_id=info:doi/10.1016/j.atherosclerosis.2019.01.033&rft_dat=%3Cproquest_cross%3E2183647341%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2183647341&rft_id=info:pmid/30777338&rft_els_id=S0021915019300577&rfr_iscdi=true |