Lysophosphatidic acid receptor 1 inhibitor, AM095, attenuates diabetic nephropathy in mice by downregulation of TLR4/NF-κB signaling and NADPH oxidase

Diabetic nephropathy (DN) is one of the major long-term complications of diabetes. Lysophosphatidic acid (LPA) signaling has been implicated in renal fibrosis. In our previous study, we found that the LPA receptor 1/3 (LPAR1/3) antagonist, ki16425, protected against DN in diabetic db/db mice. Here,...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2019-06, Vol.1865 (6), p.1332-1340
Hauptverfasser:	Lee, Jong Han, Sarker, Mithun Kumer, Choi, Hojung, Shin, Dongyun, Kim, Donghee, Jun, Hee-Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria - chemically induced Albuminuria - drug therapy Albuminuria - genetics Albuminuria - metabolism AM095 Animals Antioxidants - pharmacology Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetic Nephropathies - chemically induced Diabetic Nephropathies - drug therapy Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic nephropathy Gene Expression Regulation Hypoglycemic Agents - pharmacology Inflammatory cytokines JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism Kidney Glomerulus - drug effects Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Lysophosphatidic acid Lysophosphatidic acid receptor 1 Lysophospholipids - antagonists & inhibitors Lysophospholipids - metabolism Male Mice Mice, Inbred C57BL NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - genetics NADPH Oxidases - metabolism Oxidative Stress - drug effects Phenylacetates - pharmacology Reactive oxidative stress Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Receptors, Lysophosphatidic Acid - antagonists & inhibitors Receptors, Lysophosphatidic Acid - genetics Receptors, Lysophosphatidic Acid - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction Streptozocin Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Transcription Factor RelA - antagonists & inhibitors Transcription Factor RelA - genetics Transcription Factor RelA - metabolism
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