One-pot organocatalytic/multicomponent approach for the preparation of novel enantioenriched non-natural selenium-based peptoids and peptide–peptoid conjugates
A combined organocatalytic and multicomponent synthetic approach was designed for the preparation of selenium-based peptoids and peptide–peptoid conjugates. This single-step synthetic protocol comprises the organocatalytic asymmetric insertion of phenylselenium in the aldehyde moiety followed by the...
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| Veröffentlicht in: | Molecular diversity 2020-02, Vol.24 (1), p.1-10 |
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| container_title | Molecular diversity |
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| creator | de la Torre, Alexander F. Ali, Akbar Galetto, Fábio Z. Braga, Antonio L. Delgado, José A. C. Paixão, Márcio W. |
| description | A combined organocatalytic and multicomponent synthetic approach was designed for the preparation of selenium-based peptoids and peptide–peptoid conjugates. This single-step synthetic protocol comprises the organocatalytic asymmetric insertion of phenylselenium in the aldehyde moiety followed by the Ugi four-component reaction which results in obtaining the desired compounds in good-to-moderate yields and with good-to-excellent levels of stereoselectivity.
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| doi_str_mv | 10.1007/s11030-019-09923-w |
| format | Article |
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Graphical abstract</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Life Sciences</subject><subject>Organic Chemistry</subject><subject>Original Article</subject><subject>Peptides</subject><subject>Pharmacy</subject><subject>Polymer Sciences</subject><subject>Selenium</subject><issn>1381-1991</issn><issn>1573-501X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UUuO1DAUtBCIGRouwAJZYsPGjF-cn5doxE8aaTYgsYuenZfutBI72A6j2XEHTsDVOAke0oDEAm_KrldVtlWMPQX5EqRsLiKAVFJI0EJqXShxc4-dQ9UoUUn4dD_vVQsCtIYz9ijGo5TZBuohO1OyadoW6nP2_dqRWHziPuzReYsJp9s02ot5nTL4efGOXOK4LMGjPfDBB54OxJdACwZMo3fcD9z5LzRxcugyQy6M9kB9Zp1wmNaAE480kRvXWRiMebTQkvzYR45uO4w9_fj67URz691x3WOi-Jg9GHCK9OSEO_bxzesPl-_E1fXb95evroRVTZWEamptjEXoWzO0jTYSTVtXPVkwbQEGSl1A2dY1lppUWZRGI2YLFmgV0KB27MWWmz_6eaWYunmMlqYJHfk1dgW0qi4LyLBjz_-RHv0aXH7dnarQVV4yq4pNZYOPMdDQLWGcMdx2ILu7ArutwC4X2P0qsLvJpmen6NXM1P-x_G4sC9QmiHnk9hT-3v2f2J82fazM</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>de la Torre, Alexander F.</creator><creator>Ali, Akbar</creator><creator>Galetto, Fábio Z.</creator><creator>Braga, Antonio L.</creator><creator>Delgado, José A. 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| issn | 1381-1991 1573-501X |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Biochemistry Biomedical and Life Sciences Life Sciences Organic Chemistry Original Article Peptides Pharmacy Polymer Sciences Selenium |
| title | One-pot organocatalytic/multicomponent approach for the preparation of novel enantioenriched non-natural selenium-based peptoids and peptide–peptoid conjugates |
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