In vitro and in vivo characterization of the multiple isoforms of Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferases

•A crystal structure of Schistosoma mansoni HGPRT-1 (SmHGPRT), complexed with IMP at a resolution of 2.8 Ǻ is described.•RNA-Seq and WISH data, suggests that some HGPRT isoforms might be involved in sexual maturation and reproduction in worms.•S. mansoni has four HGPRT isoforms, here we described th...

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Veröffentlicht in:	Molecular and biochemical parasitology 2019-04, Vol.229, p.24-34
Hauptverfasser:	Romanello, Larissa, Zeraik, Ana Eliza, de Freitas Fernandes, Adriano, Torini, Juliana Roberta, Bird, Louise E., Nettleship, Joanne E., Rada, Heather, Reddivari, Yamini, Owens, Ray J., Serrão, Vitor Hugo Balasco, DeMarco, Ricardo, Brandão-Neto, José, Pereira, Humberto D'Muniz
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Catalytic Domain Helminth Proteins - chemistry Helminth Proteins - genetics Helminth Proteins - metabolism HGPRT Hypoxanthine Phosphoribosyltransferase - chemistry Hypoxanthine Phosphoribosyltransferase - genetics Hypoxanthine Phosphoribosyltransferase - metabolism Hypoxanthine-guanine phosphoribosyltransferase Isoenzymes - chemistry Isoenzymes - genetics Isoenzymes - metabolism Kinetics Molecular Sequence Data Purine salvage pathway Reproduction Schistosoma mansoni Schistosoma mansoni - chemistry Schistosoma mansoni - enzymology Schistosoma mansoni - genetics Schistosoma mansoni - physiology Sequence Alignment
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