Sirolimus‐eluting BiOSS LIM dedicated bifurcation stent in the treatment of unprotected distal left main stenosis
Background Proximal optimization technique (POT) has been proposed to adapt the conventional drug‐eluting stent (DES) with the fractal anatomy of the bifurcation. However, only few DES are labeled for post‐expansion beyond 5.0 mm. Furthermore, recrossing in the side branch (SB) through the main vess...
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| Veröffentlicht in: | Catheterization and cardiovascular interventions 2019-09, Vol.94 (3), p.323-331 |
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| creator | Briguori, Carlo Visconti, Gabriella Golino, Marco Focaccio, Amelia Signoriello, Giuseppe |
| description | Background
Proximal optimization technique (POT) has been proposed to adapt the conventional drug‐eluting stent (DES) with the fractal anatomy of the bifurcation. However, only few DES are labeled for post‐expansion beyond 5.0 mm. Furthermore, recrossing in the side branch (SB) through the main vessel (MV) stent cells may be challenging.
Objectives
To compare the sirolimus‐eluting, balloon‐expandable dedicated bifurcation stent BiOSS LIM DES versus the second generation DES in the treatment of distal unprotected left main coronary arteries (ULMCAs) lesions.
Methods
Forty‐two consecutive patients with distal ULMCA lesions were treated with the BiOSS LIM (BiOSS LIM group) in our center. A matched‐group of patients treated with second‐generation DES was selected from our database (Control group). The primary endpoint was the procedural complication rate, including (a) SB occlusion, defined as intraprocedural TIMI flow grade |
| doi_str_mv | 10.1002/ccd.28132 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2183189613</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2183189613</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-10d81010509f38d1c10543040a6ee2cb2bc55f1068e63777f2caec94ca6a942e3</originalsourceid><addsrcrecordid>eNp1kclKxEAURQtRnBf-gBS40UW3NSSVZKlxhBYXreCuqK68aEkGrQHpnZ_gN_olVpvWheDqXR7nXS7vIrRHyZgSwo61rsYsp5ytoE2aMjbKmHhYXWpaJGIDbTn3TAgpBCvW0QYnWcZzkm0iNzW2b0wb3Of7BzTBm-4Rn5rb6RRPrm9wBZXRykOFZ6YONkrTd9h56Dw2HfZPgL0F5dvFoq9x6F5s70EvLirjvGpwA7XHrTLDWe-M20FrtWoc7C7nNrq_OL8rr0aT28vr8mQy0jzlMTipckooSUlR87yiOsqEk4QoAcD0jM10mtaUiBwEz7KsZlqBLhKthCoSBnwbHQ6-MdNrAOdla5yGplEd9MFJRnNO80JQHtGDP-hzH2wX00nG8kQwnmZFpI4GStveOQu1fLGmVXYuKZGLJmRsQn43Edn9pWOYtVD9kj-vj8DxALyZBub_O8myPBssvwBbHJMJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2284623579</pqid></control><display><type>article</type><title>Sirolimus‐eluting BiOSS LIM dedicated bifurcation stent in the treatment of unprotected distal left main stenosis</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Briguori, Carlo ; Visconti, Gabriella ; Golino, Marco ; Focaccio, Amelia ; Signoriello, Giuseppe</creator><creatorcontrib>Briguori, Carlo ; Visconti, Gabriella ; Golino, Marco ; Focaccio, Amelia ; Signoriello, Giuseppe</creatorcontrib><description>Background
Proximal optimization technique (POT) has been proposed to adapt the conventional drug‐eluting stent (DES) with the fractal anatomy of the bifurcation. However, only few DES are labeled for post‐expansion beyond 5.0 mm. Furthermore, recrossing in the side branch (SB) through the main vessel (MV) stent cells may be challenging.
Objectives
To compare the sirolimus‐eluting, balloon‐expandable dedicated bifurcation stent BiOSS LIM DES versus the second generation DES in the treatment of distal unprotected left main coronary arteries (ULMCAs) lesions.
Methods
Forty‐two consecutive patients with distal ULMCA lesions were treated with the BiOSS LIM (BiOSS LIM group) in our center. A matched‐group of patients treated with second‐generation DES was selected from our database (Control group). The primary endpoint was the procedural complication rate, including (a) SB occlusion, defined as intraprocedural TIMI flow grade <3 immediately after MV stenting; and/or (b) trouble in SB access, defined as the need of ≥2 guidewires or a failure to recross in the SB trough the MV stent cells. The need of POT in the two groups was also analyzed.
Results
The primary endpoint occurred in four (9.5%) patients in the BiOSS LIM group and in 13 (31%) in the Control group (p = 0.028; OR = 4.25; 95% confidence interval: 1.25–14.43). POT was performed more often in the Control group (71% vs. 35%; p = 0.004).
Conclusions
Compared to conventional DES, the BiOSS LIM stent (1) facilitates SB recrossing and (2) fits well with the fractal anatomy of the left main bifurcation.</description><identifier>ISSN: 1522-1946</identifier><identifier>EISSN: 1522-726X</identifier><identifier>DOI: 10.1002/ccd.28132</identifier><identifier>PMID: 30773807</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Anatomy ; bifurcation lesion ; Bifurcations ; Coronary artery ; coronary artery disease ; Implants ; left main ; Lesions ; Occlusion ; Optimization ; Optimization techniques ; Rapamycin ; Stenosis ; stent ; Stents</subject><ispartof>Catheterization and cardiovascular interventions, 2019-09, Vol.94 (3), p.323-331</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-10d81010509f38d1c10543040a6ee2cb2bc55f1068e63777f2caec94ca6a942e3</citedby><cites>FETCH-LOGICAL-c3532-10d81010509f38d1c10543040a6ee2cb2bc55f1068e63777f2caec94ca6a942e3</cites><orcidid>0000-0002-2105-8186 ; 0000-0002-3326-5932</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fccd.28132$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fccd.28132$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30773807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Briguori, Carlo</creatorcontrib><creatorcontrib>Visconti, Gabriella</creatorcontrib><creatorcontrib>Golino, Marco</creatorcontrib><creatorcontrib>Focaccio, Amelia</creatorcontrib><creatorcontrib>Signoriello, Giuseppe</creatorcontrib><title>Sirolimus‐eluting BiOSS LIM dedicated bifurcation stent in the treatment of unprotected distal left main stenosis</title><title>Catheterization and cardiovascular interventions</title><addtitle>Catheter Cardiovasc Interv</addtitle><description>Background
Proximal optimization technique (POT) has been proposed to adapt the conventional drug‐eluting stent (DES) with the fractal anatomy of the bifurcation. However, only few DES are labeled for post‐expansion beyond 5.0 mm. Furthermore, recrossing in the side branch (SB) through the main vessel (MV) stent cells may be challenging.
Objectives
To compare the sirolimus‐eluting, balloon‐expandable dedicated bifurcation stent BiOSS LIM DES versus the second generation DES in the treatment of distal unprotected left main coronary arteries (ULMCAs) lesions.
Methods
Forty‐two consecutive patients with distal ULMCA lesions were treated with the BiOSS LIM (BiOSS LIM group) in our center. A matched‐group of patients treated with second‐generation DES was selected from our database (Control group). The primary endpoint was the procedural complication rate, including (a) SB occlusion, defined as intraprocedural TIMI flow grade <3 immediately after MV stenting; and/or (b) trouble in SB access, defined as the need of ≥2 guidewires or a failure to recross in the SB trough the MV stent cells. The need of POT in the two groups was also analyzed.
Results
The primary endpoint occurred in four (9.5%) patients in the BiOSS LIM group and in 13 (31%) in the Control group (p = 0.028; OR = 4.25; 95% confidence interval: 1.25–14.43). POT was performed more often in the Control group (71% vs. 35%; p = 0.004).
Conclusions
Compared to conventional DES, the BiOSS LIM stent (1) facilitates SB recrossing and (2) fits well with the fractal anatomy of the left main bifurcation.</description><subject>Anatomy</subject><subject>bifurcation lesion</subject><subject>Bifurcations</subject><subject>Coronary artery</subject><subject>coronary artery disease</subject><subject>Implants</subject><subject>left main</subject><subject>Lesions</subject><subject>Occlusion</subject><subject>Optimization</subject><subject>Optimization techniques</subject><subject>Rapamycin</subject><subject>Stenosis</subject><subject>stent</subject><subject>Stents</subject><issn>1522-1946</issn><issn>1522-726X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kclKxEAURQtRnBf-gBS40UW3NSSVZKlxhBYXreCuqK68aEkGrQHpnZ_gN_olVpvWheDqXR7nXS7vIrRHyZgSwo61rsYsp5ytoE2aMjbKmHhYXWpaJGIDbTn3TAgpBCvW0QYnWcZzkm0iNzW2b0wb3Of7BzTBm-4Rn5rb6RRPrm9wBZXRykOFZ6YONkrTd9h56Dw2HfZPgL0F5dvFoq9x6F5s70EvLirjvGpwA7XHrTLDWe-M20FrtWoc7C7nNrq_OL8rr0aT28vr8mQy0jzlMTipckooSUlR87yiOsqEk4QoAcD0jM10mtaUiBwEz7KsZlqBLhKthCoSBnwbHQ6-MdNrAOdla5yGplEd9MFJRnNO80JQHtGDP-hzH2wX00nG8kQwnmZFpI4GStveOQu1fLGmVXYuKZGLJmRsQn43Edn9pWOYtVD9kj-vj8DxALyZBub_O8myPBssvwBbHJMJ</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Briguori, Carlo</creator><creator>Visconti, Gabriella</creator><creator>Golino, Marco</creator><creator>Focaccio, Amelia</creator><creator>Signoriello, Giuseppe</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2105-8186</orcidid><orcidid>https://orcid.org/0000-0002-3326-5932</orcidid></search><sort><creationdate>20190901</creationdate><title>Sirolimus‐eluting BiOSS LIM dedicated bifurcation stent in the treatment of unprotected distal left main stenosis</title><author>Briguori, Carlo ; Visconti, Gabriella ; Golino, Marco ; Focaccio, Amelia ; Signoriello, Giuseppe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-10d81010509f38d1c10543040a6ee2cb2bc55f1068e63777f2caec94ca6a942e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anatomy</topic><topic>bifurcation lesion</topic><topic>Bifurcations</topic><topic>Coronary artery</topic><topic>coronary artery disease</topic><topic>Implants</topic><topic>left main</topic><topic>Lesions</topic><topic>Occlusion</topic><topic>Optimization</topic><topic>Optimization techniques</topic><topic>Rapamycin</topic><topic>Stenosis</topic><topic>stent</topic><topic>Stents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Briguori, Carlo</creatorcontrib><creatorcontrib>Visconti, Gabriella</creatorcontrib><creatorcontrib>Golino, Marco</creatorcontrib><creatorcontrib>Focaccio, Amelia</creatorcontrib><creatorcontrib>Signoriello, Giuseppe</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Catheterization and cardiovascular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Briguori, Carlo</au><au>Visconti, Gabriella</au><au>Golino, Marco</au><au>Focaccio, Amelia</au><au>Signoriello, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sirolimus‐eluting BiOSS LIM dedicated bifurcation stent in the treatment of unprotected distal left main stenosis</atitle><jtitle>Catheterization and cardiovascular interventions</jtitle><addtitle>Catheter Cardiovasc Interv</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>94</volume><issue>3</issue><spage>323</spage><epage>331</epage><pages>323-331</pages><issn>1522-1946</issn><eissn>1522-726X</eissn><abstract>Background
Proximal optimization technique (POT) has been proposed to adapt the conventional drug‐eluting stent (DES) with the fractal anatomy of the bifurcation. However, only few DES are labeled for post‐expansion beyond 5.0 mm. Furthermore, recrossing in the side branch (SB) through the main vessel (MV) stent cells may be challenging.
Objectives
To compare the sirolimus‐eluting, balloon‐expandable dedicated bifurcation stent BiOSS LIM DES versus the second generation DES in the treatment of distal unprotected left main coronary arteries (ULMCAs) lesions.
Methods
Forty‐two consecutive patients with distal ULMCA lesions were treated with the BiOSS LIM (BiOSS LIM group) in our center. A matched‐group of patients treated with second‐generation DES was selected from our database (Control group). The primary endpoint was the procedural complication rate, including (a) SB occlusion, defined as intraprocedural TIMI flow grade <3 immediately after MV stenting; and/or (b) trouble in SB access, defined as the need of ≥2 guidewires or a failure to recross in the SB trough the MV stent cells. The need of POT in the two groups was also analyzed.
Results
The primary endpoint occurred in four (9.5%) patients in the BiOSS LIM group and in 13 (31%) in the Control group (p = 0.028; OR = 4.25; 95% confidence interval: 1.25–14.43). POT was performed more often in the Control group (71% vs. 35%; p = 0.004).
Conclusions
Compared to conventional DES, the BiOSS LIM stent (1) facilitates SB recrossing and (2) fits well with the fractal anatomy of the left main bifurcation.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30773807</pmid><doi>10.1002/ccd.28132</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2105-8186</orcidid><orcidid>https://orcid.org/0000-0002-3326-5932</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1522-1946 |
| ispartof | Catheterization and cardiovascular interventions, 2019-09, Vol.94 (3), p.323-331 |
| issn | 1522-1946 1522-726X |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Anatomy bifurcation lesion Bifurcations Coronary artery coronary artery disease Implants left main Lesions Occlusion Optimization Optimization techniques Rapamycin Stenosis stent Stents |
| title | Sirolimus‐eluting BiOSS LIM dedicated bifurcation stent in the treatment of unprotected distal left main stenosis |
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